OBJECTIVE:To observe the clinical efficacy and safety of Chinese herbal medicine Jiawei Simiao Yongan granules (, JWSMYAG) in the treatment of non-infectious anterior uveitis (NIAU). METHODS:We conducted a single-center, randomized, open-labeled clinical trial in adults with NIAU. Patients received standard treatment or a combination of JWSMYAG (twice daily) for three months, with a 3-month withdrawal period for observation. The primary endpoint was the recurrence rate within six months. RESULTS:A total of 98 patients were included in the intention-to-treat analysis, including 49 patients in the Traditional Chinese Medicine (TCM) group and 49 patients in the control group. Compared with the control group, the number of relapses was significantly lower in the TCM group [24.5% vs6.1%, P = 0.0224; Hazard Ratio = 0.208, 95% Confidence Interval (0.059, 0.737)]; in addition, patients in the TCM group had lower symptom scores of eye pain, insomnia, and bitter taste within two weeks (all P < 0.05). There was no significant difference between the two groups in terms of the difference in best corrected visual acuity change over six months, the number of intraocular pressure elevations > 10 mm Hg, the scoring of anterior chamber cells, the number of patients with keratic precipitates (+) after 1/2 weeks of treatment, and the scores of conjunctival hyperemia, headache, photophobia, and lacrimation. The difference in the number of adverse events between the two groups over six months was not statistically significant. CONCLUSION:JWSMYAG can reduce the recurrence rate of NIAU, alleviate ocular pain, insomnia, and bitter taste symptoms in patients with NIAU, and have a favorable safety profile.

Background: The increasing prevalence of myopia among Chinese children and adolescents, especially at younger ages, has emerged as a significant concern in recent years. Pre-myopia is a key period for myopia prevention and control in children and adolescents. Previous studies suggested auricular acupressure (AA) therapy might offer a viable approach to prevent and slow down myopia progression. Nonetheless, these studies lack robust, high-quality, large-scale, multi-center evidence to conclusively support such assertions. The purpose of this research is to evaluate the efficacy, safety, and economic benefits of AA therapy in preventing myopia in Chinese children aged 6–12 years with pre-myopia. Methods: The single-blind, multi-center, parallel-group, randomized controlled trial will involve 318 pre-myopic children from 20 different centers across China. After recruitment, these participants will be randomly assigned to two groups (the AA group and the control group) at a 1:1 ratio. The AA group will receive auricular point sticking therapy along with health education for a period of 24 weeks, while the control group will be provided the sham AA treatment and routine health education. The assessments of outcomes will be conducted at the start of this study, and then after 4, 8, 12, and 24 weeks. The primary outcome is the change in spherical equivalent refraction at various follow-up times. The secondary outcomes include the number of myopia cases, uncorrected visual acuity, axial length, corneal curvature radius, accommodation amplitude, retinal and choroidal thickness, and eye behavior management. In addition, the cost-effectiveness analysis will be used as the evaluation index for economic assessment. Discussion: The results of this research will provide evidence on the efficacy, safety, and economic benefits of AA therapy in preventing myopia among children aged 6–12 years with pre-myopia in China.

Objective:To observe the effect of the direct stimulation of acupuncture at extraocular muscle attachment point on acquired extraocular muscle palsy. Methods:Thirteen patients with acquired extraocular muscle palsy were treated with acupuncture directly at extraocular muscle (paralytic muscle) attachment point. Firstly, the intraocular conjunctival sac drops of topical anesthetic (procaine hydrochloride eye drops) were administered, 0.2 mL each time, once every 10 minutes, for a total of 3 times. Acupuncture was delivered immediately after the third drop. The sterile acupuncture needle for single use, 0.25 mm×25 mm, was inserted at the anatomical location of the corneal limbal attachment of paralytic extraocular muscle, with an angle of 10° to 15° formed between the needle tip and extraocular muscle, and a depth of 0.3 mm to 0.5 mm. Pivoted by the needle tip, the eyeball was moved passively towards the direction of normal action of orbital muscle, 30 to 50 times until the patient felt soreness of the eyeball; afterwards, the needle was removed. After acupuncture, levofloxacin eye drops were administered once (0.2 mL) at the affected eye. The treatment was given twice a week, and completed when diplopia disappeared. Before and after treatment, the diplopia and the synoptophore circumference were observed respectively. Results:After 7 to 24 (15.46±5.56) times of direct stimulation with acupuncture at extraocular muscle attachment point, the symptoms of diplopia disappeared in 13 patients, the eye position restored to orthophoria, and the circumference of synoptophore was reduced to be (4.04±0.82)° from (19.38±3.98)° detected before treatment (P<0.05). Conclusion:Acupuncture directly at extraocular muscle attachment can attenuate diplopia and improve ocular muscle function in patients with acquired extraocular muscle palsy.

Several studies have reported the efficacy of traditional Chinese medicine (TCM) for central serous chorioretinopathy (CSC), while some ophthalmologists are concerned that TCM may be a risk factor for CSC as some chinese herbs contain hormonal ingredients. This study aimed to evaluate the efficacy and safety of TCM in treating patients with CSC. Randomized controlled trials (RCTs) and observational studies of TCM for CSC were searched up to July 10, 2023 on the following biological databases without language and publication time restrictions: PubMed, Ovid Medline, Embase, Cochrane Library, The Chinese National Knowledge Infrastructure Database (CNKI), Technology Periodical Database (VIP), Wanfang, and Chinese Biomedical Literature Service System (SinoMed). Review Manager V.5.4.1 and Stata 14 software were used for data analysis. Finally, thirty-eight studies were finally included including 23 RCTs and 15 cohort studies. The meta-analysis showed that compared with the routine treatment alone, the combination of TCM can not only reduce the recurrence rate (OR = 0.29, 95% CI: 0.21,0.40; I2 = 0%) and central retinal thickness (CRT) (MD = - 35.63, 95% CI: - 45.96,-25.30; I2 = 89%) of CSC, but improve patients’ best corrected visual acuity (BCVA) (SMD = 0.86, 95% CI: 0.62,1.11; I2 = 77%); additionally, it has no obvious side effects compared with routine treatment (OR = 0.72, 95% CI: 0.39,1.34; I2 = 10%). Overall, this study shows that the use of TCM does not increase the risk of CSC recurrence; on the contrary, the combination of TCM may reduce the recurrence of CSC and improve BCVA and CRT in patients with CSC compared with conventional treatment.

OBJECTIVE:To observe the clinical effect of acupuncture for glaucoma-induced optic atrophy. METHODS:A total of 70 patients (89 affected eyes) with glaucoma-induced optic atrophy were randomized into an observation group and a control group, 35 cases in each group. The control group was given basic western medicine treatment. In the observation group, on the basis of the treatment in the control group, acupuncture was applied at main acupoints i.e. Baihui (GV 20), Shangjingming (Extra), Chengqi (ST 1), Fengchi (GB 20), Zusanli (ST 36), combined with supplementary acupoints based on syndrome differentiation, once every three days, twice a week. The treatment for 3 months was required in both groups. Before treatment, after treatment and in follow-up of 6 months after treatment, the best corrected visual acuity (BCVA), intraocular pressure (IOP), indexes of visual field (visual field index [VFI], mean deviation [MD], pattern standard deviation [PSD]) and mean thickness of retinal nerve fiber layer (RNFL) were observed in the two groups. RESULTS:Compared before treatment, BCVA was decreased after treatment and in follow-up in the control group (P<0.05); in the follow-up, BCVA in the observation group was higher than that in the control group (P<0.05). On each time point before and after treatment, there was no significant difference within or between the two groups (P>0.05). After treatment and in the follow-up, the mean thickness of RNFL was larger than the control group (P<0.05). CONCLUSION:On the basis of the basic western medicine treatment, acupuncture can delay the decline of vision and the thinning of retinal nerve fiber layer in patients with glaucoma-induced optic atrophy.

Eye disease patients often suffer from liver disease, liver Qi stagnation, poor circulation of Qi and blood, and blockage of eye orifices, which leads to the onset of the disease.The depression and anxiety caused by eye disease have a great impact on the patients. Some patients with macular edema are worried about blindness and often accompanied by depression,tension, and anxiety, which worsens the condition and creates a vicious cycle. In clinical practice,the patients with decreased vision may experience emotional discomfort, stagnation of Qi, and a series of organ dysfunction, which belong to the category of "Yu syndrome" in Traditional Chinese Medicine. Depending on the patient’s condition, the treatment strategy of Traditional Chinese Medicine based on the differentiation of symptoms and signs of internal organs can be adopted,and the advantages of treating different diseases with the same method can be fully utilized. This approach can effectively alleviate depression and treat macular edema, thus relieving the bidirectional vicious cycle caused by depression due to decreased vision, and achieving good therapeutic effects.

目的 对比活体激光扫描共聚焦显微镜(IVCM)与传统的光学显微镜对睑缘蠕形螨的检出阳性率,评价其临床应用价值.方法 收集2020年10月—2021年2月期间就诊于中国中医科学院西苑医院眼科门诊的患者93例(186只眼).对同一患者分别使用IVCM法与光学显微镜法检测蠕形螨感染情况,记录不同方法检测出的蠕形螨的阳性率、漏诊率和检出蠕形螨数量的分布情况,比较光学显微镜检查法检测上、下睑缘的检出率.结果 (1)阳性率:2种方法检测蠕形螨均为阴性的患者8例(8.60%).IVCM检测阳性83例(89.25%),高于光学显微镜检测阳性的56例(60.22%),差异有统计学意义(χ2=20.755,P=0.000).(2)上、下睑缘检出蠕形螨阳性率:光学显微镜法检出上、下睑蠕形螨均为阳性或均为阴性的患者84例(90.32%),不一致的患者9例(9.68%).(3)漏诊率:IVCM法漏诊3例(3.23%),低于光学显微镜法漏诊24例(25.81%),差异有统计学意义(χ2=19.107,P=0.000).(4)蠕形螨数量的分布情况:2种检查方法检xu出不同数量蠕形螨的分布情况比较,差异有统计学意义(χ2= 42.809,P=0.000);对于同一患者IVCM法计数结果高于光学显微镜法2倍以上的患者达73例(86.90%).结论 与传统光学显微镜法比较,IVCM对睑缘蠕形螨的检出的阳性率更高,漏诊率更低,定量更为准确,具有一定的临床应用价值.

中心性浆液性脉络膜视网膜病变(简称"中浆")常因精神紧张和过度疲劳,情志不舒,气机失畅,郁而发病.中浆的发生与肝失疏泄,情绪郁结,脾失运化,痰湿阻滞,郁而化火等密切相关,患者多有抑郁和焦虑的表现,属于中医"郁证".朱丹溪首次提出"气、血、痰、火、湿、食"六郁致病之说,诸多目病,多生于郁,情志变化会导致脏腑气血平衡失调,引发多种病变."六郁"又可相继而生,气不行则血行不畅病血瘀,同样气郁可致水液代谢失常、产生湿郁、痰郁、食郁,其他郁证就会相继而生,并且"六郁"相互影响.本文从"六郁"探讨中浆病因病机及治疗,指出从"六郁"论治中浆,临床之中,往往病情复杂,又可诸郁并见,治疗需从本出发,兼顾诸症,可以起到较好疗效.

Travel entail change in geography and diet, both of which are known as determinant factors in shaping the human gut microbiome. Additionally, altered gut microbiome modulates immunity, bringing about health implications in humans. To explore the effects of the mid-term travel on the gut microbiome, we generated 16S rRNA gene and metagenomic sequencing data from longitudinal samples collected over six months. We monitored dynamic trajectories of the gut microbiome variation of a Chinese volunteer team (VT) in their whole journey to Trinidad and Tobago (TAT). We found gut microbiome resilience that VT's gut microbial compositions gradually transformed to the local TAT's enterotypes during their six-month stay in TAT, and then reverted to their original enterotypes after VT's return to Beijing in one month. Moreover, we identified driven species in this bi-directional plasticity that could play a role in immunity modulation, as exemplified by Bacteroides dorei that attenuated atherosclerotic lesion formation and effectively suppressed proinflammatory immune response. Another driven species P. copri could play a crucial role in rheumatoid arthritis pathogenesis, a chronic autoimmune disease. Carbohydrate-active enzymes are often implicated in immune and host-pathogen interactions, of which glycoside hydrolases were found decreased but glycosyltransferases and carbohydrate esterases increased during the travel; these functions were then restored after VT' returning to Beijing. Furthermore, we discovered these microbial changes and restoration were mediated by VT people's dietary changes. These findings indicate that half-year travel leads to change in enterotype and functional patterns, exerting effects on human health. Microbial intervention by dietary guidance in half-year travel would be conducive to immunity modulation for maintaining health.

爱美之心,人皆有之,而眼睛是心灵的窗户,一双炯炯有神的大眼睛能第一时间吸引人的注意.那么,爱美的人群应该如何进行眼部的防护呢? 去年10月,某位知名女演员在社交平台微博上发文求助网友如何能快速缓解眼部麦粒肿症状.一时间,网友纷纷留言,有感同身受的,也有支招儿的.有的说"麦粒肿真的太痛苦了,几年前我就长过一次,整夜都睡不着觉,总是感觉眼睛里有小石头在磨,流眼泪,尤其是扒开眼皮上药的时候真是最痛苦啊",有的说"曾经眼睛肿得睁不开",有的说"麦粒肿要记得好好擦药!不认真护理、对待的话有可能要做小手术才能取出来",还有的留言看起来十分专业,"要用酒精棉球擦拭眼睫毛根部,清洁眼部周围细菌,才能起到杀菌消毒的作用".

眼睛红、眼干涩、眼屎多的时候,您以为是上火了?眼睛磨、有异物感,您以为是眼睛进东西了?还有反复眼痒、掉睫毛,反复长针眼……其实,您要当心眼睛可能感染螨虫了! 眼睛上也有螨虫?很多眼病患者觉得不可思议,甚至闻"螨"丧胆.

突如其来的新冠疫情打乱了我们的工作生活节奏,受影响最大的应该就是青少年了,长时间封闭在家里,户外活动明显减少,但是"停课不停学",居家上网课,由于长时间近距离用电子设备,凭空又多出了不少"小四眼儿"——也算是新冠的一个特殊"并发症"吧. 当然也不能把"小四眼儿"完全归咎于疫情影响.2018年底,国家卫生健康委会同教育部、财政部组织开展了全国儿童青少年近视调查工作,结果显示2018年全国儿童青少年总体近视率为53.6％,其中6岁儿童为14.5％,小学生为36％,初中生为71.6％,而高中生的近视率高达81％.看着满课堂亮晶晶的眼镜,不能不有所触动.

青光眼是一组以急性或慢性眼压异常升高,导致视神经萎缩、视野缺损为特征的眼病.世界卫生组织已将其列为第二大致盲眼病,而且是不可逆性盲最主要的原因.研究显示,适当的运动不但能降低眼压,还可改善眼的血液循环,对青光眼患者保存视功能不无裨益.当然,并不是所有的运动都适合青光眼患者,在此我们就来聊一聊哪些运动适合青光眼患者,哪些运动或动作需要在生活中注意、避免.

"按压睛明穴轮刮眼眶……"每当眼保健操的音乐响起,同学们就会放下手中的书笔,开始享受眼睛的放松时刻.睛明穴是眼保健的重要穴位之一,穴如其名,通过按摩睛明穴,可疏经通络,令目明睛亮. 护眼要穴 睛明穴是缓解眼睛疲劳、预防近视的第一要穴,又名泪孔、泪腔、目内眦,是足太阳膀胱经的起始穴,在十二正经中,膀胱经分布广泛,主治最广.其位于目内眦旁0.1寸,将拇指与食指分别放于内眼角稍上方与鼻梁之间,用力捏揉会有酸胀的感觉,这就是晴明穴之处.

"失明"也会遗传吗? leber遗传性视神经病,又称利伯氏病,是一种由线粒体基因突变导致的母系遗传病.该病发病年龄为童年期至70岁,多数在青春期10～20岁或15～35岁发病,因此是最常见的好发于青壮年的致盲性疾病之一.

“一张一弛,文武之道”语出《礼记·杂记下》,意思是一直把弓弦拉得很紧而不松弛一下是不对的.相反,一直松弛而不紧张也是不正确的.只有有时紧张,有时放松,有劳有逸,宽严相济才是治国治国安邦的方法.现在已经引申为在生活或工作中要善于调节,有节奏地进行.

常言道:"久病成良医",事实果真如此吗? 病例1 2年前,市民王女士因双眼干涩于外院诊断为双眼干眼,使用妥布霉素地塞米松滴眼液后,眼干、眼涩症状明显缓解.后来干眼病情反复,王女士觉得该滴眼液治疗效果较好,自行于药店购买该滴眼液使用,使用时间长达2年.

麦粒肿,俗名又叫"针眼",是一种眼睑腺体的急性化脓性炎症,以局部红肿、热、疼痛,眼睑硬结及黄色脓点为主要临床表现,是眼科最常见的眼病,也是儿童常见的眼病之一. 麦粒肿是什么原因引起的? 眼睑是眼睛最外层的组织,更容易受到外界环境的刺激. 西医认为,麦粒肿主要是由于细菌(多为金黄色葡萄球菌)的感染而引起,比如小儿经常会用脏手揉眼,手上的细菌就容易乘虚而入,直接引起眼睑上腺体的感染,如果进一步发展成化脓性炎症,出现局部红肿的小包块,像小麦粒一样,则称为"麦粒肿".

The retina is sensitive to injury resulting from oxidative stress (OS) due to its high oxygen consumption. Patients with retinitis pigmentosa suffer from excessive OS. N‑acetylcysteine (NAC) is used as a mucolytic agent for the clinical treatment of disorders, such as chronic bronchitis and other pulmonary diseases. The aim of the present study was to investigate the role of hexokinase 2 (HKII) in retinal OS injury. Amyloid β (Aβ)1‑40 was used to establish a cellular model of OS. Cell viability was measured with a Cell Counting Kit‑8 assay, and the apoptosis, reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) of cells were analyzed via flow cytometry with corresponding kits. The mRNA and protein levels were detected by reverse transcription‑quantitative PCR and western blot analyses, respectively. It was observed that Aβ1‑40 reduced the expression of HKII in the mitochondria of retinal pigment epithelial ARPE cells and impaired mitochondrial antioxidant functions. Additionally, knockdown of HKII promoted apoptosis, and increased ROS levels and the MMP. NAC attenuated the inhibition of mitochondrial functions induced by Aβ1‑40. The knockdown of HKII was revealed to decrease the levels of Bcl‑2, manganese superoxide dismutase (SOD) and copper‑zinc‑SOD, and increase the levels of cleaved caspase‑3, Bax and cytochrome c. The present findings suggested that the dissociation of HKII induced by OS induces apoptosis and mitochondrial damage. This study provided improved understanding of the mechanisms underlying the effects of OS on retinal epithelial cells.

We read with great interest the article by Bennet et al 1 that investigated the impact of dietary shifts on gut microbiota. Together with several recent studies,2–5 they have shown that short-term dietary shifts can alter the composition of gut microbiota for both patients and healthy humans. However, these works drawn the conclusion with only a few time points and the subjects under investigation had undergone just one dietary shift. The dynamic patterns of microbial communities across longer time scales with multiple dietary shifts remain unclear. In this study, we recruited a Chinese volunteer team (VT) composing of 10 people who departed from Beijing, conducted a long stay of 6 months in Trinidad and Tobago (TAT) and returned to Beijing. Their faecal samples (188 samples), together with detailed dietary information, were collected using a high-density longitudinal sampling strategy (19 time points on average for VT members). We partitioned the whole longitudinal study into six phases: T1 represents pre-travel phase (20 samples), T2 (28 samples), T3 (60 samples) and T4 (21 samples) represent three time-slots when VT stayed in TAT, and T5 (35 samples) and T6 (20 samples) represent two time-slots after VT returned to Beijing. Meanwhile, we also collected samples from healthy natives of Beijing (BJN, 57 samples), TAT healthy natives (TTN, 28 samples), TAT patients (TTP, six samples) and TAT Chinese (TTC, eight samples) as control datasets. Finally, we sequenced the V4 …