Objective To develop a high-speed data acquisition system with sampling frequency of 2 GHz to meet the requirement of accurate measurement of flight time.Methods The ALTERA STRATIX Ⅲ series FPGA was used as the main control chip, matching with high-performance ADC chip with sampling frequency up to 2 GHz and sampling accuracy up to 12 bit, while extending 512 MB DDR3 SDRAM for data cache and exchanging data with the host computer through Gigabit Ethernet.In addition, a variety of PCB wiring methods were used to effectively ensure the signal integrity.Results The 250 MHz sine signal was input into the data acquisition board with 2 GHz sampling frequency,by analyzing and calculating the sampling data,acquired the following performance index of SNR=44.6639 and ENOB=7.1.Conclusion This high-speed data acquisition system based on ADC technology is a fast and reliable path and method for the measurement and analysis of biological mass spectrometry data.

Spectrophotometric quantification of turbidity by multiple optical parameters has wide-ranging applications in material analysis and life sciences. A robust system design needs to combine hardware for precise measurement of light signals with software to accurately model measurement configuration and rapidly solve a sequence of challenging inverse problems. We have developed and validated a design approach and performed system validation based on radiative transfer theory for determination of absorption coefficient, scattering coefficient, and anisotropy factor without using an integrating sphere. Accurate and rapid determination of parameters and spectra is achieved for microsphere suspension samples by combining photodiode-based measurement of four signals with the Monte Carlo simulation and perturbation-based inverse calculations. The three parameters of microsphere suspension samples have been determined from the measured signals as functions of wavelength from 400 to 800 nm and agree with calculated results based on the Mie theory. It has been shown that the inverse problems in the cases of microsphere suspension samples are well posed with convex cost functions to yield unique solutions, and it takes about 1 min to obtain the three parameters per wavelength.

为研究空气污染物扩散情况,基于学习型无线遥控传感器,采用气体直接采样法设计了一种多点组网的便携式大气采样器.可实现灵活多变的大气污染监测采样,对大气污染扩散研究提供有效样本.通过学习型无线遥控传感器的学习功能,实现了多采样器同步采样和延时采样灵活控制,完成采样器组网.采用脉宽调制(PWM)方式调整采样器的采样速度,采样速度0.1～0.8 L/min可调.对该采样器进行了测试,测试结果表明:设计的大气采样器达到预定指标,可以实现大气可靠自动采样.

Objective To develop a measurement method for determination of optical parameters of a red blood cell ( RBC) suspension based on the measurement of spatial scattered light signals without using an integrating sphere.Methods Multiple independent photoelectric sensors and light intensity modulation were used to obtain the measured values of diffuse reflectance,diffuse transmittance and collimated transmittance.The measured data results were imported into a Monte Carlo simulation based RTE to inversely determine the absorption coefficient, scattering coefficient and anisotropy factor of the measured sample using a new perturbation method.Results The described measurement method was applied to determine the optical parameters of a polystyrene microsphere suspension with a mean diameter of 2.6μm,and the results were essen-tially consistent with the calculated optical parameters by Mie code.Then, the RBC suspension was used for testing optical parameters,and the results were basically consistent with the parameters in the literature.Conclusion The system based on the measurement of spatial scattered light signals without using an integrating sphere will provide a quick and accurate approach for quantitative analysis of free hemoglobins and RBC suspensions.

Objective To design a portable respirator that can facilitate both cardiopulmonary resuscitation and auxiliary oxygen inhalation.Methods Positive pressure design as well as pneumatically powered and controlled design were adopted for this respirator.Theoretical calculation of key components was carried out.The virtual prototype was established and the structure checked using the three dimensional design software Solidedge.Finally,the prototype was processed,assembled and tested.Results Experimental tests proved that the designed respirator was capable of cardiopulmonary resuscitation and auxiliary oxygen inhalation when oxygen supply pressure reached 3 -5.5 bar.It could achieve the expected technical indicators,such as the oxygen flow rate that was between 10 and 12 L/min.Conclusion The portable oxygen supply respirator has the advantages of a small size,light weight,simple operation,and automatic power supply.It has broad prospects of application.

Objective To establish an auto-control system for high-throughput and multi-channel DNA synthesis which can simultaneously and quickly synthesize up to 96 different oligonucleotides in a 96-well microtiter format.Methods The PLC and its extended modules is used as the main-control unit, which executes the DNA automatic synthesis process according to the synthesis sequences and steps set by the user,and the manual injecting reagent etc.And the configuration software and VC6.0 were used for programming the man-machine interface sofeware to set synthesis parameters, position calibration,flux calibration data etc, and communicated with PLC.Results The synthesis application of about 150 000 DNA chains has proved that the synthesis cycle time for 96 couplings was 4 min,the average coupling efficiency was 99%across the entire 96-well plate,the monomer reagent usage was reduced by 50 percent,and the synthesis configuration was more flexible.Conclusion A reliable and simple auto-control system is provided for parallel synthesis of 96-channel oligonucleotide chains,which can meet the demands of high-throughput and multi-channel DNA synthesis.

The intelligent instrument for measuring eutectic and co-melting point of freeze-drying material were designed based on resistivity method. Series and parallel joint divide voltage method were designed to increased the measurement rang of impedance. The Relative error of the impedance measuring method was tested. The results show that in the measurement range of 1kΩ~9000kΩ, the relative error of the impedance is less than 8%. Determinant for the eutectic and co-melting point was choosed according to the temperature-impedance curve. Several material were tested, the experiment results show that the instrument can measured the eutectic and co-melting point automatically.

To improve the signal-to-noise ratio of diffuse reflectance,diffuse transmittance and collimated transmittance signals,optical modulation is adopted to detect the spatially scattered light of the measured turbid media for the first time. First,the incidence light is modulated by the rotating frequency of turnplate.Second,inspect the spatially scattered light on multi spots around the measured sample,and demodulate the collected datas by DFT;Third,extract the maximum harmonic components as the measured results of spatially scattered light on multi spots.The described method is applied to determine the optical parameters of 0.7μm,8% polystyrene microspheres solution sample and the accuracy of the inverse solution has been examined.The experimental results show that the optical modulation can improve the signal-to-noise ratio of the spatially scattered light signals of the measured turbid media.This method can provide a new rapid and accurate approach for optical study and material analysis of turbid medium samples.

Objective To develop a set of MCU control system for the data communication between MCU and the touch screen to achieve human-machine interaction.Methods The serial communication method between the touch screen and MCU STC89C58RD+ based on Modbus protocol was studied.The hardware interface used standard RS232 protocol,with the touch screen as the host device and STC as the slave one.Results Trails proved that the touch screen could realize the functions of display,manipulation and etc.Conclusion The control system,being stable and reliable,can realize human-machine interaction,and the design of the hardware and software is convenient,so that the design requirements are met.

The principle of vacuum freeze-drying and application status are introduced,and the freeze-drying process is described,which falls into pre-treatment process,pre-freezing,sublimation drying,desorption drying and post-treatment process.The design parameters of freeze-drying curve are analyzed,which includes pre-freeze cooling rate,the minimum pre-freezing temperature,pre-freezing time,the cooling time and temperature of the condenser,vacuum time,the starting time of heating,and so on.The tracking and following of the progress of the freeze-drying process in China and foreign countries,along with the experience,contribute a lot to the development of high-quality freeze-drying equipment.

提出了一款基于等离子和药液雾化的空气消毒器样机的研制过程和方法.从应用背景、产品目标出发,分析了原理方案、关键部件选型设计,采用三维仿真设计软件CATIA进行了结构设计和外观设计,实现了空气净化、中药药液消毒和等离子消毒的统一.经样机实际测试,整机安全性高,运行可靠,操作便捷.

Objective To explore a lyophilization process of plasma solution. Methods The plasma solution freeze-drying experiments was made and freeze-dried curve and freeze-dried products quality were analyzed to optimize the lyophilization process. Results The required plasma products which comply with freeze-dried standard were made. Conclusion Freezing drying is the main way to preserve biological products. The experiment should not only ensure the plasma solution freeze-dried well, but also keep the biological activity and consider the issue of energy consumption.

Objective To develop a hyper-cryotrap device with magnetic stirrer to give a new choice of stirring reagent under low temperature condition,which can work automatically under a setting temperature.Methods The main hardware of the instrument was constituted by the cooling system,magnetic stirrer system and temperature control system.It could work under a wide temperature range and stir reagent in both circle ways.Results The system ran well reaching the designed requirements.Conclusion With the characteristics of high reliability,and the convenient design of software and hardware,the instrument has a bright future in the market and its application.

There are two key aspects in vacuum freeze-drying technology:freeze-drying process and equipment.The research situation and development of freeze-drying formulation and freeze-drying curve of freeze-drying process are introduced,and the research focuses of the freeze-drying all over the world are on two aspects:how to control crystal nucleus formation and crystals growth and how to make freeze-drying process under strict control.The development of freeze-drying equipment is analyzed from the aspects of cooling system,control system and integrated freeze-drying production line,concluding that there is a small gap between the international level.At last the development and significance of the freeze-drying technique in the pharmaceutical industry are described.

The control system of radiating therapeutic instrument, powerful and reliable, is designed with the new chips of P89LPC669 and MAX669. Its hardware organization, system function and software framework are introduced in this paper.