AIM: To establish UV and HPLC methods to determine the content of tegaserod tablet. METHODS: HPLC method——the separations were obtained on a Diamonsil C18 column which was maintained at 40 ℃, the mobile phase was acetonitrile 1% sodium dodecyl sulfate (contain 0.95% acetic acid) (56∶44, V∶V), the flow rate was 2 mL·min -1 and the detection wavelength was 314 nm. UV method——absorption was determined at 314 nm. RESULTS: HPLC method——calibration was linear from 0.1-120 mg·L -1 ( r =0.9999). Within day and between day coefficients of variation were less than 3.1 % . The recovery was between 100.42 % - 103.82 % . UV method——calibration was linear from 2-20mg·L -1 ( r =0.9998). Within day and between day coefficients of variation were less than 1%. The recovery was between 101.06 %-103.02 %. CONCLUSION: HPLC and UV method both appear to be suitable for determination of the content of tegaserod tablet while we are apt to use the UV method for its simplicity if the related impurity is controlled well.