The objective of this study was to build models to predict complete pathologic response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in esophageal squamous cell carcinoma (ESCC) patients using radiomic features. A total of 55 consecutive patients pathologically diagnosed as having ESCC were included in this study. Patients were divided into a training cohort (44 patients) and a testing cohort (11 patients). The logistic regression analysis using likelihood ratio forward selection was performed to select the predictive clinical parameters for pCR, and the least absolute shrinkage and selection operator (LASSO) with logistic regression to select radiomic predictors in the training cohort. Model performance in the training and testing groups was evaluated using the area under the receiver operating characteristic curves (AUC). The multivariate logistic regression analysis identified no clinical predictors for pCR. Thus, only radiomic features selected by LASSO were used to build prediction models. Three logistic regression models for pCR prediction were developed in the training cohort, and they were able to predict pCR well in both the training (AUC, 0.84-0.86) and the testing cohorts (AUC, 0.71-0.79). There were no differences between these AUCs. We developed three predictive models for pCR after nCRT using radiomic parameters and they demonstrated good model performance.

The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy.

OBJECTIVES:Radiation-induced hypothyroidism is the most common thyroid disorder after radiotherapy in nasopharyngeal carcinoma (NPC) patients. This study evaluated the pattern of radiation-induced thyroid gland changes in 48 months after radiotherapy in NPC patients and the association of hypothyroidism incidence with thyroid dose. METHODS:Fifty-six NPC patients treated by intensity modulated radiotherapy in 2013 were recruited. All patients received baseline thyroid hormones (fT3, fT4 and TSH) tests and CT scan before radiotherapy. Repeated measures of the thyroid hormones and gland volume were performed at 3, 6, 12, 18, 24, 30, 36 and 48 months after treatment. Trend lines of the thyroid volume and hormone level changes against time were plotted. The incidence of hypothyroidism patients and its relationship with the dose were also evaluated. RESULTS:The mean thyroid volume followed a decreasing trend after radiotherapy, reaching a minimum (-39.8%) at 30 months and slightly increased afterward. The fT4 level followed a similar pattern with its mean value dropped by 21.5% at 30 months and became steady after 36 months. TSH level showed gradual rise from just after radiotherapy, reaching a peak at 24 months and became relatively steady after 36 months. The incidence of hypothyroidism increased to a maximum at 24 months (28.6%) and dropped afterwards. Thyroid Dmean and D50 were significantly correlated with hypothyroidism incidence in 12 to 30 months (ρ > 0.40, p < 0.05). CONCLUSION:The patterns of radiation induced thyroid volume shrinkage and fT4 level reduction were similar, with both of them showed decreasing trend from 0 to 30 months. The thyroid volume and function reached a relatively steady state after 36 months. The incidence of hypothyroidism increased up to 24 months and its frequency was associated with the thyroid dose.

Table S1. Spearmanâ s rank self-correlation matrix of clinical and dosimetric variables. (XLS 26 kb)

目的:探讨应用PSBH方法开展大学生营养教育及对不合理生活方式进行早期干预的作用.方法:应用"解决问题、促进健康"方法,通过举办营养教育讲座、发放营养知识和健康生活方式宣传手册、并采用KAP调查问卷对汕头大学200名不同专业本科学生进行营养教育干预前、后调查.结果:营养教育干预前,大学生的营养知识相对缺乏,部分营养知识的答题正确率不到50％.部分大学生存在一些不正确的饮食行为.实施PSBH项目后,大学生营养知识显著提高(P<0.05),营养态度明显改善(P<0.01)、不合理饮食行为也明显改变.结论:通过PSBH项目,对在校大学生的生活方式进行干预,可提升在校大学生对营养知识的了解,促进良好营养态度的形成,纠正不合理的饮食行为和生活习惯,对预防常见慢性病有积极意义.

目的：了解城镇生源、农村生源大学新生营养知识、态度及饮食行为现状，为开展大学营养健康教育提供依据。方法采用调查问卷的形式对汕头大学医学院2014级197名新生进行营养知识、态度及饮食行为的横断面调查。结果医学新生营养知识缺乏，平均（23.30±7.88）分，低分人数占32.0%，高分人数仅占29.4%；城镇生源学生营养知识平均得分高于农村生源学生（t=2.058，P<0.05）。67.0%的医学新生对饮食和营养状况具有良好的态度，不同生源学生比较，无显著性差异（P>0.05）。对于吃夜宵习惯，72.6%的城镇生源学生回答“有时吃”，明显高于农村生源学生的54.9%（χ2=6.474，P<0.05）。多元Logistic回归分析显示，营养知识得分与学生“吃夜宵习惯”呈负相关（P<0.05），“城镇生源”和“男性”与学生“有时吃夜宵”和“经常吃夜宵”呈正相关（P<0.05）。结论大学新生营养态度较为积极，但城乡生源大学新生营养知识、饮食行为存在显著差异，应注意结合城乡生源的差异特点开展大学生营养教育。