Background The exact aetiology of vitiligo has not yet been established. Oxidative stress is involved in the pathophysiology of vitiligo. It has been described that some polymorphisms in the catalase (CAT) gene may affect the risk of vitiligo. However, the results were inconsistent.Objective We performed a meta-analysis of the published studies to derive a more precise estimate of the association between CAT T/C at codon 389 in exon 9 polymorphisms and vitiligo risk.Methods The PubMed, Medline, Cochrane Library, China National Knowledge Infrastructure (CNKI) databases were searched to identify relevant published studies.Results Four case-control studies (cases, 645; controls, 689) that investigated the association between C/T polymorphisms of CAT exon 9 and the risk of vitiligo were retrieved and analysed. Our findings suggested a significant association between the CAT T/C exon 9 polymorphism and vitiligo risk (CT + TT vs. CC pooled odds ratio, 1.43; 95% confidence interval, 1.14-1.80; P = 0.002).Conclusion We found a significant correlation between the CAT T/C exon 9 polymorphism and the risk of vitiligo.

报告1例寻常性银屑病并发成人型线状IgA大疱性皮病。患者男,36岁。因全身红色斑疹伴白色鳞屑反复发生20年,躯干、双上肢出现环状排列的水疱10 d伴瘙痒就诊。皮损组织病理检查:表皮下水疱,疱内、真皮浅层和真皮乳头见中性粒细胞、嗜酸性粒细胞浸润;皮损周围皮肤直接免疫荧光显示基膜带IgA、IgG呈带状沉积;取患者血清行BP180NC16A（大疱性类天疱疮18 000抗原的近膜片段）-ELISA检查显示阴性;以盐裂正常人皮肤为底物,取患者血清行间接免疫荧光检查显示IgA、IgG呈带状沉积在真皮侧。诊断为寻常性银屑病并发成人型线状IgA大疱性皮病。