Tanshinone Ⅱ A (Tan Ⅱ A) is an extract of traditional Chinese medicine Salvia miltiorrhiza,which can play a natural antioxidant effect.It is mainly used in the treatment of cardiovascular disease.Which has anti-atherosclerosis,reduced myocardial infarct size and improve myocardial oxygen consumption,inhibition of thrombosis,inhibition of platelet aggregation,antitumor activity and other effects,and are mainly used for the treatment of cardiovascular disease in clinical applications.In recent years,a large number of clinical studies and animal experiments have confirmed that tanshinone Ⅱ A in the inhibition of colon cancer cell proliferation,promote cell apoptosis,promote cell invasion and metastasis and other aspects of prominent anti-cancer effect,making it the object of concern to researchers.In this paper,tanshinone ⅡA anti-colon cancer effect of studies were reviewed.

目前,结直肠癌是影响人类健康最常见的肿瘤之一.我国结肠癌的发病率日益增加,它是位于我国第5位、世界第3位的恶性肿瘤.虽然结直肠癌治疗的相关研究取得了一定进展,但其治疗手段仍然以手术及放化疗为主,术后的复发及转移仍是治疗的关键难题[1].因此寻找有效的结肠癌治疗途径迫在眉睫.我国古代用砷类矿物药砒霜即三氧化二砷(As2O3)治疗牛皮癣、梅毒及一些恶性肿瘤.1865年Lissaver用亚砷酸治疗慢性粒细胞白血病被认为是历史上首次使用抗癌药物治疗恶性肿瘤[2].

三氧化二砷(As2O3)作为一种化疗药物,在多种肿瘤的治疗中取得了一定的疗效,被广泛应用于基础研究和临床研究中.然而不良反应限制了其在临床中的应用,因此如何减少不良反应是As2O3在肿瘤治疗中的研究重点.本文就As2O3在肿瘤治疗中的不良反应机制及减少不良反应的方法 做一综述.

目的 探讨转录因子EGR-1对人肿瘤细胞的化疗增敏作用.方法 应用Pubmed及Cnki期刊全文数据库检索系统,以“Egr-1基因、肿瘤、化疗”为关键词进行相关文献检索.结果 Egr-1基因的表达存在于绝大多数的肿瘤中并对肿瘤的发生和发展具有抑制或促进作用,对化疗药物可能起到增敏作用.

Objective: To investigate the effects of arsenic trioxide (As2O3) combined with 3’-azido-3’-deoxythymidine (AZT) on the migration and invasion of human liver cancer HepG2 cells, and to explore its possible mechanism.Methods: The liver cancer HepG2 cells were treated with As2O3 or AZT alone or in combination; meanwhile, the HepG2 cells without any treatment were used as the blank control. The migration and invasion of HepG2 cells were measured by wound healing assay and Transwell migration and invasion assays, respectively. The expression mRNA levels of matrix metallopeptidase 2 (MMP2) and vascular endothelial growth factor (VEGF) were detected by real-time fluorescent quantitative-PCR. The protein expression levels of MMP2, VEGF, extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylated ERK1/2 (p-ERK1/2) were detected by Western blotting.Results: The migration and invasion abilities of HepG2 cells in As2O3 combined with AZT group were significantly decreased than those in the blank control, As2O3 and AZT alone groups (all P 0.05).Conclusion: As2O3 combined with AZT has synergistic inhibitory effects on the migration and invasion abilities of HepG2 cells. The effect may be related to phosphorylation of ERK1/2 pathway and down-regulation of MMP2 and VEGF expressions. DOI:10.3781/j.issn.1000-7431.2015.11.230