Objective:To observe the efficacy and safety of camrelizumab combined with albumin-paclitaxel/lobaplatin as neoadjuvant therapy for locally advanced esophageal cancer.Methods:From 2019 to 2020, 18 patients with locally advanced esophageal squamous cell carcinoma who were initially unresectable were treated with neoadjuvant therapy of camrelizumab combined with albumin-paclitaxel/lobaplatin for 3-4 cycles before operation, and the operation was evaluated after treatment. The surgical removal rate (R 0), pathological complete response (pCR), major pathological response (MPR), the neoadjuvant objective response rate (ORR) and safety were observed. Results:The median age of 18 patients was 59 years (32-66 years). The neoadjuvant treatment completion rate was 89% (16/18). The R 0 rate was 61% (11/18), with pCR 45% (5/11), MPR 64% (7/11) and ORR 69%. The incidence of adverse reactions were neutropenia (78%), thrombocytopenia (61%) and reactive cutaneous capillary endothelial proliferation (61%), but the main adverse reactions were grade 1-2. The postoperative complications were mild. Conclusion:As a neoadjuvant therapy, camrelizumab combined with albumin-paclitaxel/lobaplatin can improve the pathological response rate of locally advanced esophageal cancer with good safety.

目的:调查肺癌患者的尊严感现状及影响因素,为护理干预提供理论依据.方法:采用中文版患者尊严量表对136例原发性肺癌患者的尊严感现状进行调查.结果:肺癌患者尊严总分为(55.42±10.75)分.存在明显尊严受损90例,占66.18％.不同学历和经济来源的肺癌患者的尊严得分不同,差异均有统计学意义(均P<0.05).不同学历的肺癌患者尊严的症状困扰维度、生存状况维度、社会支持维度不同,差异均有统计学意义(均P<0.05),且学历越低得分越高.不同经济来源的肺癌患者尊严的心理状况维度、生存状况维度不同,差异均有统计学意义(均P<0.05),且经济来源为家属支持的肺癌患者得分高.结论:肺癌患者存在明显尊严受损,学历、经济来源是影响肺癌患者尊严感的因素.护理人员应重视尊严维护护理、尊严疗法等干预手段,不断提升肺癌患者的尊严感.

目的 探讨阿帕替尼联合肝动脉化疗栓塞术(TACE)治疗晚期肝癌的临床效果.方法 回顾性分析1例接受阿帕替尼联合TACE治疗的晚期肝癌男性患者的临床资料,并进行相关文献复习.结果 该患者在TACE后病情缓解时间短的情况下,联合阿帕替尼治疗后病情缓解时间明显延长,出现高血压不良反应,对症治疗得到有效控制,随访20个月无进展.结论 对于TACE疗效欠佳的晚期肝癌患者,选择阿帕替尼联合TACE治疗,可获得临床长时间缓解,不良反应轻.

目的 探讨全脑放疗联合表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)与联合化疗在非小细胞肺癌脑转移中的疗效.方法 回顾性分析,将2014年1月至2018年2月在青岛大学附属医院接受治疗的60例非小细胞肺癌脑转移患者作为研究对象.按照治疗方法分为两组:观察组27例,给予全脑放疗联合EGFR-TKIs治疗;对照组33例,给予全脑放疗联合化疗治疗;比较两组患者的临床治疗情况、无进展生存期(PFS)以及不良反应发生情况.结果 观察组患者颅内病灶客观缓解率(ORR)、疾病控制率(DCR)分别为74.1％、96.3％,全身病灶ORR、DCR分别为74.1％、92.6％,均显著高于对照组(39.4％,72,7％,36.4％,75.8％),差异具有统计学意义(P<0.05);观察组患者治疗后颅内及颅外PFS分别为(13.42±3.74)个月、(12.46±3.12)个月,均高于对照组[(8.82±1.56)个月,(8.56±1.24)个月],差异有统计学意义(P<0.05);1年生存率(66.7％)高于对照组(39.4％),差异具有统计学意义(P<0.05);且观察组治疗后不良反应发生率(22.2％)明显低于对照组(42.4％),差异具有统计学意义(P<0.05).结论 全脑放疗联合EGFR-TKIs治疗非小细胞肺癌脑转移,临床效果好,无进展生存期长,不良反应少,值得推广应用.

Objective:To observe the clinical effects of compound cantharides Capsule on Th 17 /Treg cell imbalance in gastric cancer and quality of life.Methods:A total of 60 cases of gastric cancer selected in Qingdao Cancer Hospital from September 2015 to August 2017 were observed and divided into control group and observation group ,with 30 cases in each group.The control group received chemotherapy with FOLFOX4 regimen,and 14 d as a treatment course for 4 cycles.The observation group was additionally treated with Fufang Banmao Capsules ,0.75 g /time,2 times /day.The 2 groups were treated with 21 d as a treatment cycle for 2 cycles.After treatment,serum tumor markers CEA,CA19-9,CA242 and CA72-4 levels,quality of life score(SF-36),toxic and side effects,survival rate,percentage of Th17 cells in peripheral blood,percentage of Treg cells and Th17 /Treg ratio in 2 groups were compared.Results:1)Peripheral blood CA19-9,CEA,CA72-4 and CA242 decreased after treatment in 2 groups.Compared with control group,the observation group decreased significantly (P＜0.05); 2)Body,role,emotional,social and overall quality of life scores in 2 groups were higher than that before treatment.The observation group was better than control group (P＜0.05); 3)The major adverse reactions of 2 groups were myelosuppression and gastrointestinal symptoms.Occurrence difference of bone marrow suppression in 2 groups had no statistical differences ( P＞0.05).The incidence rate of gastrointestinal symptoms in observation group was lower than that of the control group (P＜0.05).4)Peripheral blood Th17 cells than,the percentage of Treg cells and Th17 /Treg decreased in 2 groups.The observation group decreased more significantly than control group ( P＜0.05).The differ-ences were statistically significant ( P＜0.05).Conclusion:There is a significant immune escape phenomenon in gastric cancer. Fufang Banmao capsules can improve the curative effects of gastric cancer by correcting the imbalance of Th 17 /Treg cells and quality of life of patients.

目的 观察肺癌患者血清癌胚抗原(CEA)、神经特异性烯醇化酶(NSE)、细胞角蛋白19片段(CY-FRA21-1)水平在化疗前后的变化情况.方法 回顾性分析90例肺癌患者的临床资料.统计分析化疗前后血清CEA、NSE、CYFRA21-1变化情况,探讨其在评价肺癌患者临床疗效中的应用价值.结果 肺腺癌CEA水平均高于肺鳞癌和小细胞肺癌,小细胞肺癌NSE水平均高于肺鳞癌和肺腺癌,肺腺癌高于肺鳞癌,肺鳞癌CYFRA21-1水平高于肺腺癌和小细胞肺癌,差异均有统计学意义(P﹤0.05).CEA、NSE、CYFRA21-1阳性率分别在肺腺癌、小细胞肺癌、肺鳞癌中最高,分别为77.4％、88.2％、76.2％.90例肺癌患者化疗后无完全缓解(CR)患者.肺鳞癌部分缓解(PR)患者化疗后CYFRA21-1水平低于化疗前,肺腺癌PR患者化疗后CEA、CYFRA21-1水平均低于化疗前,小细胞肺癌PR患者化疗后NSE水平低于化疗前,差异均有统计学意义(P﹤0.05).结论 CEA、NSE、CY-FRA21-1肿瘤标志物对于肺癌化疗疗效监测和评价具有重要意义,但不能单独判断疗效及预后,仍需结合影像学改变进行综合评价.

瑞香狼毒为药用狼毒的正品，具有抗肿瘤作用。其作用机制包括调节肿瘤细胞周期、抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、调整免疫细胞功能、逆转肿瘤细胞的多药耐药等多个方面。