Objective:To investigate the expression levels of microRNA-21-3p(miR-21-3p)and Runt-related transcription factor 3(RUNX3)in severe acute pancreatitis and their predictive value for the progression of the disease.Methods:One hundred patients with acute pancreatitis admitted to Shifang People′s Hospital between March 2020 and March 2022 were selected as research objects and divided into control group(n=50, mild acute pancreatitis)and observation group(n=50, severe acute pancreatitis)according to their disease conditions.Real-time fluorescence quantification polymerase chain reaction(PCR)was used to detect the expression level of miR-21-3p, and enzyme-linked immunoassay was used to detect the expression level of RUNX3.The differences in the expression levels of miR-21-3p and RUNX3 between the two groups were compared, and the relationships between miR-21-3p and RUNX3 and the deterioration of severe acute pancreatitis were analyzed by Logistic regression analysis.Receiver Operating characteristic(ROC)curve was drawn to analyze the application value of miR-21-3p and RUNX3 in predicting and diagnosing the deterioration of severe acute pancreatitis.Results:The level of miR-21-3p in the observation group was significantly higher than that in the control group, and the level of RUNX3 in the observation group was significantly lower than that in the control group, with statistically significant differences(P<0.05). The miR-21-3p level in survivors was lower than that in deaths, while the RUNX3 level in survivors was higher than that in deaths(P<0.05). Logistic results showed that the high expression of miR-21-3p was a risk factor for the worsening(death)of severe acute pancreatitis, and the high expression of RUNX3 was a protective factor for the worsening(death)of severe acute pancreatitis(P<0.05). ROC curve showed that the AUC(0.835, 95% CI: 0.742-0.928)of the combined diagnosis of miR-21-3p and RUNX3 in predicting the deterioration of severe acute pancreatitis was the largest, and the sensitivity and specificity were 83.33% and 93.18%(P<0.05), respectively.Conclusion:miR-21-3p is highly expressed in the worsening process of severe acute pancreatitis, and RUNX3 is lowly expressed in the worsening process of severe acute pancreatitis.The combined diagnosis of the two indexes can predict the development of severe acute pancreatitis, which can provide a certain auxiliary role for the early diagnosis of patients.

近些年来重症患者营养支持的病症越来越受到国家和社会的重视,根据临床治疗显示,营养不良会造成患者的发病概率明显上升,死亡率增高,可能会影响到患者本身的身体健康,增加患者发病概率和延长住院时间,随着医院临床研究表明营养不良的症状已经取得可以治疗的效果,科技和应用技术的不断进步,医院研发出了营养治疗方法现在已经广泛应用于临床研究当中,各个临床医院的医生应当重视重症患者营养支持的营养补充效果.

医学发展,部分重症疾病治愈率也逐年提升,但是ICU重症患者的治疗依然存在部功能障碍,这就需要在后续治疗中加强康复治疗.监护病房应注意康复干预,并可有效减少并发症出现.