Objective To analyze the preoperative personal characteristics of glioma patients and to explore the association of their personal characteristics with clinical factors.Methods A retrospective analysis was conducted on 85 patients with gliomas (tumor group) who were admitted to Department of Neurosurgery of Affiliated Hospital of Southwest Medical University from February 2016 to December 2018.Minnesota Multiphasic Personality Inventory (MMPI) was used for assessment before surgery.Meanwhile,41 healthy volunteers who volunteered to undergo the MMPI assessment at Mental Health Center of Affiliated Hospital of Southwest Medical University during the same period were enrolled as controls (healthy control group).The results of MMPI scores were compared between the 2 groups.The relationship between Karnofsky Performance scale(KPS) score,tumor grade,location and side of patients with glioma and MMPI score was further analyzed.Results There was no significant difference in age,gender,education level or income between the 2 groups (all P ＞0.05).Compared with normal control group,the scores of 9 scales of MMPI in tumor group,including Lie (56.0 ± 11.5 vs.50.0 ±10.0),Validity (53.0 ± 10.6 vs.41.7 ± 8.8),Hypochondriasis (55.6 ± 11.2 vs.44.2 ± 8.3),Depression (49.2 ±9.6 vs.42.2 ± 10.3),Masculinity-femininity (49.9 ±9.4 vs.42.8 ± 14.0),Psychasthenia (51.5 ± 10.0 vs.40.9 ± 11.5),Schizophrenia (51.2 ± 10.6 vs.40.2 ± 10.6),Hypomania(51.8 ± 9.1 vs.47.7 ± 9.4),Social introversion (46.6 ± 8.7 vs.36.7 ± 13.0),were significant increased (all P ＜ 0.05).Meanwhile,compared with normal control group,the score of Correction in tumor group was significant decreased (52.1 ± 13.9 vs.58.8 ±12.1,P =0.009).The scores of Lie,Correction,Hypochondriasis and Hysteria were significant different statistically between KPS ＞80 group and KPS≤80 group (P ＜0.05).The scores of Depression were significantly different between frontotemporal group and non-frontotemporal group (P ＜ 0.05).Moreover,the scores of Masculinity-femininity were significantly different between low grade glioma group and high grade glioma group (P ＜0.05).There was no significant difference in the scores of each scale among right,left and bilateral glioma patients (all P ＞ 0.05).Conclusions Patients with gliomas usually have some abnormal psychological personality,including evasion,over self-worry,emotional depression,nervousness,anxiety and so on.The KPS scores,tumor grade and location seem to have certain effects on their psychological personal characteristics respectively.

研究观察玛咖生物碱对小鼠结肠癌CT-26细胞成瘤能力的影响并初步探讨其可能机制.构建BALB/c小鼠CT-26细胞移植瘤动物模型,随机分为玛咖生物碱高剂量组、玛咖生物碱低剂量组及生理盐水模型对照组.连续灌胃用药27d,绘制小鼠体重增长曲线及移植瘤体积增长曲线.第28 d处死小鼠,计算抑瘤率、相对肿瘤增殖率、脾脏指数;ELISA法检测血清IL-2、IFN-γ水平;HE切片观察移植瘤、脾脏、肝脏及肾脏组织学形态变化.结果 表明,与对照组比较,实验组移植瘤重量明显降低(p＜0.05),抑瘤率分别为43.37％和45.26％,组织学观察实验组移植瘤坏死面积较对照组明显增大.实验组小鼠脾脏指数明显高于对照组(p＜0.05),且实验组脾脏白髓增生较显著.同时,血清IL-2及IFN-γ水平均明显高于对照组(p＜0.05).可见,玛咖生物碱可以通过提高小鼠免疫力抑制CT-26细胞的成瘤.

Objective To discuss the prevalence and clinical features of pre-and post-operative mood disorders in patients with gliomas.Methods A retrospective analysis was conducted on 76 patients of gliomas who underwent surgical resection between July 2015 and June 2017 at Neurosurgery Department of the Affiliated Hospital of Southwest Medical University.Hamilton depression scale (HAMD),Hamilton anxiety scale (HAM-A) and Bech-Rafaelsen Mania rating scale (BRMS) were used for evaluation at 2-3 days before surgery and 5-7 days post surgery.Results Compared with the pre-operative conditions of 76 patients with gliomas,their postoperative HAMD scores were significantly decreased (13.5 ± 3.2 vs.9.8 ± 1.5,t =3.010,P ＜ 0.05).Significant reduction was seen in the proportion of patients with postoperative depression [42.1％ (32/76) vs.15.8％ (12/76),x2 =12.795,P ＜ 0.01].There was no significant difference between pre-and post-operative HAMA scores (10.1 ± 2.8 vs.12.8 ± 4.6) or between pre-and post-operative proportions of patients with anxiety [38.2％ (29/76) vs.50.0％ (38/76)] (both P ＞ 0.05).No significant difference was observed between pre-and post-operative BRMS score (7.5 ± 2.1 vs.8.7 ± 2.5) or pre-and post-operative proportions of patients with mania [2.6％ (2/76) vs.3.9％ (3/76)] (both P ＞0.05).The results showed that postoperative HAMD scores in pathologically high level group,frontal and temporal lobes group and right side group were significantly lower than those prior to surgery (all P ＜ 0.05).Multiple linear stepwise regression analysis showed that household income was vital to preoperative HAMD scores of glioma patients (β =-0.573,t =-3.427,P ＜ 0.01) and was negatively correlated with preoperative HAMD scores.Conclusions Some glioma patients may present with mood disorders of varying extent and types both before and after surgery.Depression seems to be closely related to the location of glioma.Family income could be an independent influencing factor for preoperative HAMD score.

胶质瘤患者手术前后均可能存在不同程度的精神障碍[1],但神经外科医师常常更关注如何延长患者生存时间,对胶质瘤相关精神障碍的评估及治疗有所忽略,导致患者生活质量降低,也给患者家庭照顾者带来了极大困扰[2, 3].全面了解胶质瘤患者精神心理状况可以更好地评价预后、提高患者生存质量.本文就近年来胶质瘤患者精神障碍相关研究进展展开综述.