Hollow (hollow periodic mesoporous organosilica, HPMO), core-shell (mSiO2@PMO), and bowl (nanobowl periodic mesoporous organosilica, BPMO) organic mesoporous silica nanoparticles were produced in this work. According to adsorption and desorption studies, all three have large pore diameters (2-10 nm), high specific surfaces (567-726 m2g-1), and large pore volumes (0.4-1.4 cm3g-1). After transporting the antitumor pharma-ceutical doxorubicin (DOX) and ZnO-controlled pH stimulation response modification, the obtained DOX@P-MOs@ZnO has a high drug loading rate (17-37%, with the largest drug loading capacity up to 378 mu g/mg). Cell uptake and apoptosis tests revealed that the three morphologies of DOX@PMOs@ZnO had high cellular uptake and inhibitory effects. These results showed that the DOX@PMOs@ZnO preparation may be beneficial for tumor-targeted therapy. More importantly, when three unique morphologies of DOX@PMOs@ZnO were analyzed in terms of drug loading, cell uptake, and apoptosis, the findings showed that the hollow structure of DOX@HP-MO@ZnO and the bowl-like structure of DOX@BPMO@ZnO had more substantial impacts in all areas.

As one of the new anti-tumor methods, drug delivery systems have received extensive attention from researchers. In this study, by the seed anisotropic growth method, with spherical TiO2 as the core, rod-shaped mesoporous silica was grown on the surface of TiO2 in anisotropic manner to prepare ball-rod structure TiO2&mSiO2. Through the surface functional modification method, folic acid is used as the targeting group and doxorubicin hydrochloride (DOX) as the target drug to construct a functionalized redox stimulus-responsive TiO2&mSiO2 drug delivery system. Structure characterization by methods such as SEM, TEM, BET, XRD and FT-IR. In vitro drug release experiments, hemolysis experiments, and cytotoxicity experiments on HeLa cell line confirmed that the drug delivery system has good biocompatibility and GSH concentration-dependent drug release behavior. Cell uptake experiments and apoptosis experiments show that the system has good cell penetration behavior. The prepared redox TiO2&mSiO2 drug delivery system provides a new idea for the clinical treatment of tumors.

An adsorbent ZO (oxidized ZIF-8-derived carbon) was prepared on the ZIF-8-derived carbon (ZC) by modified Hummer’s method. The removal rate and adsorption amount of Pb 2+ were measured on the different molar ratios of 2-Hmim to 2, 2′-bipyridine in ZO, including 1:1 (1:1 ZO) and 1:2 (1:2 ZO). The adsorption experiments show that the best condition to adsorb Pb 2+ in Pb 2+ solution for 1:1 ZO is an adsorbent dosage of 20 mg, adsorption time of 16 h, initial Pb 2+ concentration of 15 mg/L, and pH = 3; that for 1:2 ZO is the adsorbent dosage of 15 mg, adsorption time of 18 h, initial Pb 2+ concentration of 15 mg/L, and pH = 4. The adsorption data fits the quasi-second-order kinetics ( R 2 = 0.99998), indicating that chemical adsorption plays a leading role. The fitted isotherm adsorption curve is more consistent with the Langmuir adsorption model (1:1 ZO, R 2 = 0.95058; 1:2 ZO, R 2 = 0.97488). The competitive adsorption results show that the removal rate of Pb 2+ by 1:1 ZO and 1:2 ZO is more than 98%, indicating that 1:1 ZO and 1:2 ZO have a superior selectivity for Pb 2+ competing with Cu 2+ and Fe 2+ . The maximum adsorption amount of Pb 2+ is 15.52 mg/g by 1:1 ZO and 18.09 mg/g by 1:2 ZO. This study shows that 1:2 ZO is more helpful for the removal of Pb 2+ than 1:1 ZO.

It has been widely reported that the shape of nanoparticles can significantly affect their nonspecific uptake into tumor cells. In this work, We prepared three different morphologies of mesopomus silica nanoparticles and explained the mechanism, and three types of multifunctional mesoporous silica nanoparticles with different morphological characteristics (DOX@MSN-x-PEG-FA) was first synthesized using rosin as an additive agent, and then constructed for targeted drug delivery systems (TDDS) carrying doxorubicin (DOX) as a model drug. The morphology and structural properties of these nanoparticles were characterized by means of SEM, TEM and N-2 adsorption/desorption, and the biocompatibility of blank nanoparticles was evaluated by hemolysis assay. Utilizing the kinetic model, the loading and releasing mechanisms of DOX were also evaluated. The drug adsorption process is mainly carried out by chemical adsorption (covalent bonding), and the release process followed an anomalous (non-Fick) transport mechanism. These DOX@MSN-x-PEG-FA exhibited a pH-dependent and sustained drug release behavior which are the required properties for drug delivery systems. Compared to the other two samples, DOX@MSN-80-PEG-FA possessed the highest cell-targeted uptake capacity and apoptosis rate, indicating that it is a promising drug delivery system for cancer-targeted therapy.

In the process of cancer treatment, due to the complexity, diversity and heterogeneity of tumors, most conventional anticancer drugs show a narrow therapeutic window. Therefore, the current trend of clinical research has gradually shifted from a single treatment to a dual-drug or multi-modal combination therapy with different therapeutic effects. Janusparticles can independently control the release of different drugs, reducing mutual interference between modes. In this review, the preparation methods and mechanisms of Janusnanomaterials, the application of the Janusnanoplatform based on chemotherapy in the field of multi-mode combined anti-tumor applications, and the challenges faced by Janusnanomaterials are summarized.