BACKGROUND:Extramammary Paget's disease (EMPD) is considered an intraepithelial adenocarcinoma. Paget's disease of the penis is the most common disease of EMPD in male patients.OBJECTIVE:The objective of this study was to investigate and improve our knowledge of the clinical features, diagnosis, therapeutic methods and outcome of penile Paget's disease.MATERIALS AND METHODS:Eleven patients from 2007 to 2012 with Paget's disease of the penis were analyzed retrospectively based on diagnosis, treatment and the results on follow-up. All patients received local expanding resection with intraoperative frozen sections and reconstruction of defects with split-thickness skin graft from autologous thigh tissue.RESULTS:All surgeries were successful, and the postoperative course was uneventful with complete wound healing and graft survival. No lymph node metastasis was obtained. Both the morphology of the penis and its function were well maintained.CONCLUSIONS:Chronic skin lesions of the penis should be biopsied as soon as possible, if they are suspected to be due to Paget's disease. Paget's disease of the penis should be treated with wide local excision and intraoperative frozen section examination. In addition, reconstruction of defects with split-thickness skin graft from the patient's thigh is an ideal choice for treatment.

目的:探讨手术治疗阴茎Paget病对患者性生活质量的影响.方法:回顾性分析南京医科大学第一附属医院及江苏省省级机关医院自2008年至今手术治疗10例阴茎Paget病患者的临床资料.结果:10例均行局部扩大切除术及自身皮瓣修补术.术前3例无性生活,7例在术后2个月左右恢复性生活.总体患者术后3及6个月时的性生活质量比术前明显好转.结论:手术是治疗阴茎Paget病的一种有效的方法,可以改善患者的性生活质量,并且这种改善效果在术后3个月时最明显.