[Objective]To compare the clinical efficacy of catheter directed thrombolysis(CDT)and peripheral ve-nous thrombolysis(AVT)in the treatment of acute lower deep vein thrombosis(LDVT).[Methods]A total of 70 cases of patients with acute LDVT in Shuyang People's Hospital were collected for the study and divided into the CDT group(n=36,treated with inferior vena cava filter and CDT)and the AVT group(n =34,treated with AVT).The clinical effi-cacy,venous angiography,coagulation and fibrillation indexes and complications were compared between the two groups.[Results] The significant curative effects were shown in the two groups after operation.The circumference difference of legs and uninjured limb after thrombolysis was significantly smaller than that before thrombolysis(P <0.05),and the decrease rate and swelling rate of the CDT group were better than those of the AVT group(P <0.05).and the concen-trations of D-dimer and FDP at 24h of thrombolysis were significantly higher than those before operation(P <0.05),and the concentrations at the end of thrombolysis were significantly lower than those at 24h of thrombolysis or those before thrombolysis(P <0.05).And the PIB level at 24h of thrombolysis was significantly lower than that before operation(P<0.05)and significantly higher than that at the end of thrombolysis(P <0.05),and the changes degrees of the above indexes in the CDT group were significantly greater than those in the AVT group.The total incidence rate of postoperative complications was 30.55%(11/36)in the CDT group and 20.58%(7/34)in the AVT group,therefore there was no sig-nificant difference in the postoperative complications between the two groups(χ2=0.91,P >0.05).[Conclusion] CDT and AVT both have good effects in the treatment of acute LDVT.There are no significant differences in the incidence rate of complications in the use of CDT and AVT,but the swelling rate and thrombolysis rate of CDT are better than those of AVT,therefore CDT is more suitable for LDVT treatment.

目的 对比微创椎弓根螺钉内固定术在胸腰段脊柱骨折治疗中的临床疗效.方法 选取在我院接受胸腰段脊柱骨折的72例患者,其中36例观察组患者接受经皮微创椎弓根螺钉内固定术治疗,36例对照组患者接受开放式椎弓根螺钉内固定术治疗,比较两组患者的临床治疗效果.结果 观察组患者在手术切口长度、出血量、引流量、住院时间和疼痛评分、Cobb's角、椎体矢状面指数、椎体前缘高度等等方面均优于对照组(P<0.05),两组患者在术前时间比较,差异无统计学意义(P>0.05),术后各指标比较,差异无统计学意义(P>0.05).结论 经皮微创椎弓根螺钉内固定术在胸腰段脊柱骨折治疗过程中具有疼痛小、恢复快和效率高等特点.

随着年龄的增长,腰腿痛的发生率也逐年升高.引起腰腿痛的原因很多,其中椎间盘退行性病变是其发生的主要病因.从分子生物学角度探讨其发病机制,有望为延缓、修复、甚至扭转椎间盘退行性变提供可行的理论依据.本文对椎间盘退行性变与相关生物分子因素的研究进展进行综述,并据此展望其发展趋势.