Objective: To establish a reversible rabbit model of obstructive jaundice which was easy to execute internal and external biliary drainage. Methods:36 New Zealand rabbits were randomly divided into three groups:external biliary drainage group(group A), internal biliary drainage group(group B) and sham operation group(group C). In groups A, B, reversible rab-bit model of obstructive jaundice was established, including cutting off common bile duct, putting silica gel duct in hepatic and duodenal ends, fixing both ends by suturing, occluding silica gel duct and then subcutaneously sewing. Rabbits were subjected with operation again at the 7th day postoperatively: external biliary drainage was formed by shearing off silica gel duct and puting vitro, and internal biliary drainage was formed by removing occlusion. In sham operation group, rabbits were subjected with liberating common bile duct and making loose knot. Blood of all animals was collected preoperatively , at 7th day postoperatively and 7th day after second operation. Liver function was detected by automatic biochemistry analyzer. Liver and bile duct were observed by ultrasound postoperatively and at 7th day postoperatively and 7th day after second operation. Liver tissue was collected at 7th day after second operation , and the pathology of liver was observed. Results: The reversible rabbit model of obstructive jaundice was established. There was no significant difference in liver function of groups A, B, C postoperatively. The level of total bilirubin (TB), direct bilirubin (DB), alanine transarninase(ALT) andγ-glutamyl transferase (γ-GT) were higher in groups A, B than those in groups A, B preoperatively and group C at 7th day postoperatively. At 7th day after second operation, the level of TB, DB, ALT and γ-GT after internal and external drainage in groups A, B were decreased, and there was no significant difference in groups A, B, C. It was shown that liver enlarged diffusely, gallbladder enlarged, intra-hepatic and common hepatic duct expanded significantly in groups A, B compared with group C by ultra-sound at 7th day postoperatively, while liver enlarged unconspicuously, gallbladder atrophied, intra-hepatic and common hepatic duct expanded unconspicuously at 7th day after second operation. Meanwhile , it was shown that structure of hepatic lobular recovered basically, hepatic sinus expanded mildly, a few inflammatory cells infiltrated portal area with hyperplasia of fibrous tissue in group A compared with group C, while no inflammatory cell infiltrated portal area in group B at 7th day after second operation. Conclusion: The reversible model of obstructive jaundice had great advantages for it was simple, reliable, effective and repeatable.

Objective To explore the ability of computed tomography angiography in the response evaluation of transarterial chemoembolization for HCC. Methods A total of thirty-eight consecutive patients with unresectable HCC received two cycles of TACE. Unenhanced and contrast-enhanced CT examinations of the upper abdomen were executed one week before the first treatment and four weeks after the second treatment. The feeding arteries were reconstructed by maximum intensity projection and volume rendering with the preoperative and postoperative CT data of arterial phase. The change of the tumor feeding artery was described with disappeared,narrowed,unchanged,enlarged,new artery emerged. Tumor response was evaluated according to the modified RECIST. Results Five patients got a CR. Each feeding vessel was well occluded and couldn't be recognized in CTA. Twenty-four patients got a PR. In this group,more than half of their feeding vessels disappeared or narrowed obviously. The rest of nine patients with four lesions got a SD,whose feeding vessel unchanged or narrowed partly. Conclusion The changes of feeding arteries by CTA is a feasible and tangible method for evaluating the treatment response to transarterial chemoembolization therapy for HCC.