Objective:To compare the survival and prognostic factors of intraoperative radiotherapy (IORT) and postoperative radiotherapy (PORT) in female patients, aged≥50 years, diagnosed with node-negative breast cancer (≤ 3 cm in size).Methods:Clinical data of eligible early breast cancer patients between 2010 and 2015 were obtained from the SEER database. Patients were divided into the IORT and PORT groups according to the radiotherapy record and propensity score matching (PSM) was subsequently conducted. Kaplan-Meier curve was used to evaluate the overall survival (OS) and breast cancer-specific survival (BCSS) between two groups and Cox proportional hazard regression analysis was used to explore the risk factors of clinical prognosis.Results:7 068 patients were included after PSM. The median follow-up time was 32.0 months. The 5-year OS rates in the IORT and PORT groups were 96.8% and 93.8%, respectively. Univariate Cox analysis showed that radiotherapy, age, histological grade, T stage, estrogen receptor (ER) status and progesterone receptor (PR) status were the independent risk factors for OS, and histological grade, T stage, ER status, PR status and chemotherapy were the independent risk factors for BCSS. Multivariate Cox regression analysis demonstrated that patients who received IORT had better OS than PORT counterparts ( P=0.020). Besides, patients aged≥60 years obtained worse OS than those aged<60 years ( P=0.003). Patients with T 2 stage or ER-negative tumors had worse OS than those with T 1 stage tumors ( P<0.001) or ER-positive tumors ( P=0.001). Patients with grade Ⅲ-Ⅳ tumors achieved worse BCSS ( P=0.004). Subgroup analysis showed that IORT yielded better OS for elderly patients (≥60 years), grade Ⅲ-Ⅳ tumors, infiltrating duct carcinoma, T 2 stage tumors, ER-positive tumors, PR-positive tumors and patients without chemotherapy. Conclusions:IORT may bring benefit for highly selected patients with low risk of recurrence, which is not inferior to PORT in terms of short-term survival. Prospective studies with longer follow-up time are needed to confirm the findings.

新型冠状病毒肺炎工作区的工作人员穿戴防护装备后,因防护服无口袋设计,导致常用工具(如笔、纸等)携带不便.针对此情况,本研究设计了一款一次性便携式储物装置,有效解决工作中的不便.

目的:研究乳腺癌术后护理中循证护理干预的价值,为后期开展护理工作提供依据.方法:病例样本为2018年9月～2019年9月时间段我院收治的66例乳腺癌手术患者,分组方式为随机数字表法,平均划分为2组,即研究组和对照组,两组样本量保持一致,n=33,两组患者均实施常规基础护理干预措施,研究组患者在此基础上实施循证护理干预,研究比较两组患者护理效果.结果:患肢功能恢复率指标比较,研究组高于对照组(P<0.05),并发症发生率指标比较,研究组低于对照组(P<0.05).结论:乳腺癌术后护理中采取循证护理干预临床效果显著,可降低并发症发生率,改善患肢功能,值得临床推广应用.

新型冠状病毒感染所致肺炎简称"新冠肺炎"(NCP),近期新冠肺炎在我国突然来袭且疫情发展趋势不断蔓延,确保院内医疗物资供给是保障抗击疫情效果的关键.二级库管控模式是成本、费用、核算管理中重要的控制点,本文将着重分析新型冠状病毒肺炎疫情下防护物资二级库管控模式的实施方法 、问题、对策及意义,以及为提高各级医疗机构疫情期间物资管控效果、确保抗击疫情有效性及安全性提供有利参考依据.