Objective To investigate the effect of high active antiretroviral therapy ( HAART) on growth and development of infants born to pregnant women infected with human immunodeficiency virus (HIV) and the effect on blocking mother to children transmission.Methods Totally 165 pregnant women diagnosed with HIV infection from May 2006 to May 2017 and their 169 infants, including four pairs of twins were enrolled, and 82 infants born to HIV negative pregnant women in the same period were enrolled as control .All of the pregnant women in the experimental group were administrated with HAART when HIV antibody test was positive.The delivery intervention and artificial feeding were carried out as well.The weight, height, hemoglobin (Hb), serum iron and serum calcium level of infants at birth , 12 months and six years old were monitored and compared between the two groups.Apgar scores of newborns and intelligence tests at six-year-old were also recorded.Statistical analysis was performed by t test.Results Pregnant women were generally in good conditions and well tolerated to the drugs.There were no significant differences in neonatal Apgar scores , body weight, body length, Hb, serum iron, serum calcium and CD4+T lymphocyte count between HIV positive experimental group and control group (t ＝-1.27,-1.12,-3.41,-5.62,-0.89,-3.02 and-0.74, respectively, all P＞0.05).At the age of 12 months, there were no significant differences in body weight , length, Hb, serum iron, serum calcium and CD4+T lymphocyte count between the two groups ( t ＝1.02, 1.41, 1.32, 1.03, 0.89 and 1.06, respectively, all P ＞0.05).At the age of six years, there were no significant differences in all indexes between the two groups (t＝1.02, 0.87, 1.58, 1.03, 0.92 and 2.07, respectively, all P ＞0.05).Intelligence assessment was performed in 78 children of the experimental group and 45 children of the control group at the age of six years , and there was no significant difference between the two groups ((89.7 ±12.5) score vs (91.2 ±13.7) score, t＝1.67, P＝0.43).All the children in the experimental group were positive for HIV antibody at birth , and six cases were positive for HIV RNA who were diagnosed with neonatal HIV infection.HAART was initiated for the six cases , while HIV antibody tests were still positive until the age of 18 months after HAART.The rest of the children′s HIV antibody tests became negative with the mother to children tramsission rate of 3.55%(6／169).Conclusion HAART could not only block mother to children tramsission of HIV , but also has no effect on growth and intellectual development of children during the observation period.

Objective: To understand the pregnant finale and embryo or fetal infection of those pregnant women with HCMV infection. Methods: ELISA method was used to test 4148 pregnant women's TORCH infection in Cangha area. Results: Among 4148 tested pregnant women, 62 cases HCMV-IgM positive, positive frequency was 1.5%. 58 cases were proved intrauterine infection with embryo or fetus. In these 58 cases, pregnant finale were: spontaneous abortion 31%(18/58), fetal death and abnormal pregnancy 19%(11/58), significantly higher than other abnormal pregnancy (P0.001). Conclusion: HCMV intrauterine infection is one of important reasons that may cause spontaneous abortion, fetal death and abnormality. Advanced level of antenatal care and pregnant women's immunity, avoiding and reducing of high risk factor's contacting are main methods to lower intrauterine infection. Furthermore, popularization aristogenesis detect is the important method to prevent fetal infection of TORCH in intrauterine.

目的比较硬膜外麻醉剖宫产术时罗比卡因和布比卡因对心电图及心肌酶的影响.方法择期剖宫产手术病人30例,硬膜外麻醉时Ⅰ组(15例)用0.5%罗比卡因,Ⅱ组(15例)用0.5%布比卡因.观察麻醉手术期间心电图P-R、QRS波间期以及肌酸磷酸激酶(CK)和同工酶(CK-MB)的变化,同时观察麻醉镇痛、肌松效果和不良反应.结果两组病人P-R、QRS波间期均在正常范围内(P＞0.05).两组病人CK术后24 h值明显高于术前(P＜0.05),但反映心肌受损特异性较高的CK-MB则无明显变化(P＞0.05),两组间亦无差异(P＞0.05).麻醉效果及不良反应两组间无差异.结论硬膜外麻醉时罗比卡因与布比卡因对心电图及心肌酶影响无明显差异.