目的 分析奥氮平结合康复训练改善老年痴呆精神行为障碍患者认知功能的效果.方法 选取我院2019年1月—2022年2月收治的90例老年痴呆精神行为障碍患者为研究对象,根据随机数字表法分为两组.对照组(n=45)采用奥氮平治疗,观察组(n=45)在对照组基础上进行康复训练.比较两组患者的简易精神状态评估量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、生活质量综合评定问卷(GQOLI-74)评分及治疗总有效率.结果 干预前,两组的MMSE和MoCA评分比较,组间差异无统计学意义(P>0.05);干预后,观察组的MMSE、MoCA评分分别为(18.46±3.22)分、(17.66±3.08)分,均高于对照组的(17.09±3.06)分、(16.27±2.84)分,组间差异有统计学意义(P<0.05).干预前,两组的各项GQOLI-74评分比较,组间差异无统计学意义(P>0.05);干预后,观察组的各项GQOLI-74评分均高于对照组,组间差异有统计学意义(P<0.05).观察组的治疗总有效率为91.11％,高于对照组的75.56％,差异有统计学意义(P<0.05).结论 奥氮平结合康复训练应用于老年痴呆精神行为障碍患者中,可有效改善其认知功能,提高生活质量,值得临床推广使用.

Objective To explore the rehabilitation efficacy of Orem self -care mode on the psychological and behavioral symptoms of patients with vascular dementia (VD).Methods 63 patients with VD who met the inclusion criteria ,were divided into the control group and the observation group ,30 cases each in random order .The two groups of patients were treated with donepezil to improve cogni-tion,while the observation group used Orem self -care mode on the basis of that .Two groups respectively used the clinical global impres-sions scale(CGI)to assess the effect before the intervention and 6 weeks after the intervention,also adopting the BEHAVE -AD to assess the psychological and behavior symptoms of dementia .Results CGI-SI scores of the observation group after the intervention was differ-ent from that of the control group,and the difference was statistically significant (t=5.751,P<0.01).BEHAVE-AD total scores and behavioral disorders ,aggressive behavior ,emotional symptoms factor scores of the observation group after the intervention were all differ -ent from those of the control group,and the differences were respectively statistically significant (t=5.022~7.157,P<0.01).Conclu-sion Application of Orem self -care mode shows a significant role in the improvement of psychological and behavioral symptoms of pa -tients with VD.