Objective To investigate the clinical significance of the relationship between serum C reactive pro-tein (CRP) and time in patients with acute carbon monoxide poisoning (ACOP). Methods A retrospective analysis was performed on 90 cases of ACOP patients, who admitted to Department of Emergency of our hospital from November 2014 to March 2017. According to the degree of poisoning on admission, these patients were divided into three groups:mild poisoning group, moderate poisoning group, severe poisoning group, with 30 cases in each group. Meantime, 30 cases of health examination in the same hospital were taken as the control group. The serum CRP at 12, 24, 48, 72, 96 hours after admission was tested and compared. The patients with ACOP were followed up for 2 months after treatment. According to whether the appearance of delayed encephalopathy, the patients were divided into encephalopathy group and encephalopathy group. The correlation between the difference of CRP value between different groups and the degree of poisoning with the pathogenesis of delayed encephalopathy were analyzed. Results Twelve hours after the admis-sion, the CRP levels of the control group, Mild poisoning group, moderate poisoning group, severe poisoning group were re-spectively (3.35±0.91) mg/L, (3.81±0.28) mg/L, (13.26±1.85) mg/L, (26.70±1.70) mg/L, and the differences between the three groups were statistically significant (P<0.05). With the prolongation of treatment time, the level of CRP in different carbon monoxide poisoning groups showed an increasing trend. The CRP level in the mild and moderate poisoning group reached the highest value at 24 h, and then decreased gradually. The CRP level in the severe poisoning group reached the highest value at 48 h, and then decreased gradually. In the severe poisoning group, the serum CRP levels at 24 h, 48 h, 72 h and 96 h after ad-mission were significantly different from those in the mild poisoning group and moderate poisoning group (P<0.01). After the treatment, the patients with ACOP were followed up for 2 months. The patients were divided into the encephalopathy group (30 cases) and non-encephalopathy group (60 cases) according to whether there was delayed encephalopathy, and the encepha-lopathy group were all moderate and severe poisoning patients. Conclusion Early CRP value can be used as an indicator di-agnose the degree of poisoning and predicate the prognosis of patients.

目的：观察食管内局部注射沙培林对食管癌患者放疗后免疫功能的影响。方法选择92例行食管癌放疗患者，随机分为观察组和对照组各46例。对照组行常规放疗方案前无操作；观察组于放疗前在胃镜引导下行食管内局部注射沙培林5KE，20d 后再次局部注射沙培林5KE，完成放疗疗程。随访观察对照组和观察组治疗前后机体免疫状态变化，同时记录患者局控率及生存期。结果观察组机体内免疫状态检测 CD3+ T、CD3+ CD4+ T 及CD3+ CD8+ T 分别为（65.29±0.57）％、（36.52±0.47）％、（31.42±0.42）％，对照组检测结果分别为（65.31±0.42）％、（35.19±0.21）％、（29.19±0.13）％，2组体内 CD3+ CD4+ T 及 CD3+ CD8+ T 细胞免疫水平差异有统计学意义（t ＝17.523、34.401，P ﹤0.01）；随访2年，观察组生存率为23.08％，中位生存时间16个月，对照组生存率为11.54％，中位生存时间10个月，2组比较差异有统计学意义（P ﹤0.05）。结论食管癌患者放疗前局部注射沙培林能够保护放疗患者机体内细胞的免疫功能，改善患者放疗后体内免疫环境，增强抑瘤效应，提高生活质量，延长生存期。