痤疮为常见损容性、慢性炎症性皮肤病,青春期多发,往往对青少年的学习和心理造成不同程度的影响.痤疮的发生机制多为青春期皮脂腺分泌旺盛,毛囊皮脂腺导管开口处过度角化导致皮脂排出受阻,以及痤疮丙酸杆菌过度繁殖导致的慢性炎症反应,表现为局部皮肤粉刺、丘疹、囊肿或者结节样皮损.痤疮的临床治疗主要包括局部外用或口服抗生素、维A酸,局部外用水杨酸以及各种激光设备及手术[1].但由于细菌耐药性逐渐增加、系统药物副作用较大,安全有效的物理疗法成为治疗痤疮的新趋势.光动力疗法(photodynamic thera-py,PDT)是一种具有高选择性的药械联用技术,广泛应用于皮肤科炎症性、传染性、癌症及癌前病变等多种皮肤科疾病的治疗,是局部外用治疗皮肤科疾病的一项新型诊疗技术.近年来,随着光动力疗法应用的不断更新和发展,临床对光动力疗法在痤疮治疗中的认识和研究也在不断丰富.现将PDT治疗原理、治疗参数的选择、疗效及不良反应的研究进展综述如下.

Objective To observe the clinical effect of external use of imiquimod combined with ozone oil after laser operation of condylo-ma acuminatum. Methods Sixty condyloma acuminatum patients were retrospectively analyzed from Feb 2017 to May 2018 and were randomly di-vided into two groups with 30 patients in each group. The treatment group was treated with CO2laser for external use of imiquimod combined with ozone oil and the control group was treated by CO2laser therapy with imiquimod combined with ciprofloxacin gel. They were followed up at 2 weeks and 4 weeks after operation,and the wound healing and condyloma acuminatum recurrence circumstance were recorded. Results The wound healing rate was 86.7% in treatment group,which was higher than that of the control group 60.0%,the difference was statistically significant (P ＜0.05);and the recurrence rate 30.0% in treatment group was lower than that of the control group 56.7% with statistically significant difference (P ＜0.05). Conclusion External use of imiquimod combined with ozone oil after laser operation of condyloma acuminatum is effec-tive. It was good for mucosal wound healing and can reduce recurrence rate. Therefore,it is worth for clinical practice.

Objective Through the external using chemokine- like factor 1 (CKLF1) antagonism peptides C19 topical administration, to investigate its function in the mouse model with atopic dermatitis. And to analyze the relationship between C19 concentration and the therapeutic effect of atopic dermatitis in mice. Methods The mouse models of atopic dermatitis were established by sensitizating with ovalbumin (OVA) through the skin.55 BALB/c mice were randomly divided into atopic dermatitis (AD) group, control group, prevention group and treatment group a, b and c, 11 mice in each group. The control group and dermatitis group were treated with topical 0.9％ sodium chloride treatment. The treatment groups (a, b and c) were treated with C19 topical application of 0.1 μg/ml, 1.0 μg/ml and 10.0 μg/ml, respectively. At the end of treatment, the lesions of mice in each group were observed and recorded. The lesions and serum of mice were collected and the histopathological changes, the related inflammatory factors and the serum total IgE level were observed. Results ①Compared with the blank control group,dermatitis group and the treatment group showed obvious edema, erythema, exudation, dander, scab and other skin rash on the local skin of the mice. The modeling was successful.②After treatment, local skin appearance and histopathological inflammation of AD mice were alleviated after local topical treatment with C19. Compared with dermatitis group, inflammatory factors IL-4 and IL-5 in tissue homogenate were significantly decreased in treatment group c (P ＜0.05), while there was no significant difference between the treated group and the dermatitis group (P ＞0.05). Compared with the dermatitis group, the levels of inflammatory cytokines IL (P ＜0.05), while IL- 13 and Eotaxin decreased significantly in treatment group a, b and c, and the difference was statistically significant. There was no significant difference in a, b and c groups (P ＞0.05). Conclusion CKLF1 antagonist peptide C19 can play a therapeutic role in skin- specific absorption in mouse- specific dermatitis model. The effect of high concentration C19 in serum IgE and tissue homogenate IL-4 and IL-5 is better than that of low concentration C19. In Eotaxin and IL- 13, its therapeutic effect has no concentration dependence.