病人,男,57岁.因呕血、黑便1天于2018年6月20日入院.2016年因腹主动脉假性动脉瘤行腹主动脉覆膜支架腔内隔绝术,8天前行髂动脉支架置入术,术后恢复顺利出院.既往无消化道出血病史.体格检查:皮肤、巩膜苍白,腹部平坦,未见胃肠蠕动波,无腹壁静脉曲张,上腹压痛,无反跳痛及肌紧张,肝脾肋下未触及,墨菲征阴性,全腹叩诊呈鼓音,移动性浊音阴性,肠鸣音正常,未闻及气过水声.辅助检查:红细胞计数2.40×1012/L,血红蛋白67g/L.白细胞计数13.86×10/L,中性粒细胞百分比78.1％.给予输血、补液、抑酸、抗炎等对症治疗.复查血红细胞计数2.35×1012/L,血红蛋白67g/L,白细胞计数10.12×109/L,中性粒细胞百分比79.1％.

Objective To investigate the clinical values of the leukocyte count,D-dimer,histidine decarboxylase (HDC) and intestinal fatty acid binding protein (I-FABP) for diagnosing acute intestinal obstruction.Methods Sixty patients who treated in China-Japan Union Hospital of Jilin University from January 2017 to January 2018 were collected prospectively,and were divided into strangulated intestinal obstruction (STR-IO) group (n =20),simple intestinal obstruction (SIM-IO) group (n =20) and peritonitis group (n =20).Twenty healthy volunteers were collected as control group.Automatic blood cell analyzer was used to detecting the leukocyte count.The concentration of plasma D-dimer was detected by immune turbidimetry method.The concentration of serum HDC and I-FABP were measured by enzyme linked immunosorbent assay (ELISA) method.Compared the above indicators of four groups of samples.The measurement data are expressed as mean ± standard deviation (Mean ± SD).Tamhane's T2 and Dunnett's T3 methods were used to comparison between groups.Estimation of receiver operating characteristic curve(ROC) and area under curve (AUC) used logistic regressive model.Results The leukocyte count in control group,SIM-IO group,peritonitis group,and STR-IO group were (6.97 ± 1.68) × 109/L,(8.24 ± 2.78) × 109/L,(11.33 ±4.75) × 109/L,and(12.53 ± 5.96) × 109/L respectively.STR-IO group and peritonitis group were significantly higher than those of control group(F =12.74,P =0.01),but there was no significant difference between SIM-IO group and control group(P ＞ 0.05).The concentration of plasma D-dimer in control group,SIM-IO group,peritonitis group,and STR-IO group were (0.44± 0.30) μg/ml,(1.17 ± 0.67) μg/ml,(1.20 ± 0.72) μg/ml,and (1.67 ± 0.67) μg/ml respectively.The concentration of D-dimer in STR-IO group was significantly higher than those of control group (F =57.08,P =0.00),and there was no significant difference among other group (P ＞ 0.05).The concentration of serum HDC in control group,SIM-IO group,peritonitis group,and STR-IO group were (5.51 ±4.30) ng/ml,(14.33 ± 3.71) ng/ml,(11.53 ± 4.67) ng/ml,and (35.65 ± 21.15) ng/ml respectively.The concentration of HDC in STR-IO group was significantly higher than those of other three groups (F =39.03,P =0.00).The concentration of serum I-FABP in control group,SIM-IO group,peritonitis group,and STR-IO group were (0.20 ± 0.06) ng/m],(0.31 ± 0.17) ng/ml,(0.22 ±0.03)ng/ml,and (0.81 ±0.56) ng/ml respectively.The concentration of I-FABP in STR-IO group was significantly higher than those of other three groups (F =23.07,P =0.01).The AUC of HDC,I-FABP,D-dimer,and leukocyte count were 0.998,0.868,0.730,and 0.704 respactively.Conclusion Leukocyte count,D-dimer,and HDC or I-FABP combined detection may be a more effective index for diagnosing acute intestinal obstruction.

病人,男,70岁.因腹痛、腹胀伴停止排便、排气3天入院.3天前无明显诱因出现腹痛、腹胀伴恶心、呕吐,呕吐物为胃内容物,伴停止排气、排便.1天前上述症状进行性加重,当地医院诊断为肠梗阻,给予对症治疗未见明显好转.急诊以肠梗阻收入我院.既往风湿性心脏病病史20年,否认家族性遗传病史.体格检查:腹部饱满,未见胃肠型及蠕动波,无腹壁静脉曲张,上腹部压痛,无反跳痛,无肌紧张;肝脾肋下未触及,Mur-phy征阴性;全腹叩诊呈鼓音,移动性浊音阴性;肠鸣音活跃,可闻及气过水声.