腰椎间盘突出症(lumbar disc herniation,LDH)是一种由脊神经根受压和/或刺激引起的疼痛综合征,典型症状为腰痛(low back pain,LBP)伴有下肢放射性疼痛、感觉异常和/或肌肉无力等症状,严重影响患者的生活质量[1].LDH的发病率为31％,终生患病率为60％～80％[2],其中只有3％～5％的LDH患者患有LBP伴腰神经病(lumbar radiculopathy,LR)症状[3].阶梯化治疗是目前治疗LDH的有效方案,早期保守治疗可减缓病情发展,有效避免手术治疗.其中腰椎牵引是治疗LDH的常用方法,在临床保守治疗中应用广泛,也是各种手法治疗的基础.在英国和美国,分别有41％和77％的LDH患者通过腰椎牵引进行治疗[4、5],在缓解LBP症状方面有一定的疗效[6、7].

The proximal medial column of the humerus is a continuous cortical region in the inner and lower part of the humerus head, which has attracted more and more attention in clinical and scientific research since it was proposed. It has been shown to increase the stability of internal fixation, maintain the height of the humeral head to prevent varus, and reduce the risk of screw penetration. Biomechanical studies have also shown that the medial column has an outstanding performance in increasing the stiffness, torsion resistance, and shear resistance of the locking plate. Although it has many benefits, there is no unified definition of its concept and specific region, and the existing classification does not include the medial column, therefore more researches are required to provide supporting information. The methods of medial column reconstruction mainly include locking plate combined with talus screw, locking plate combined with bone grafting, internal and external double plate combined support, locking plate combined with bone cement, and humeral cage. These methods have their own characteristics, however they will increase the cost of surgery and bring new complications. How to determine the best way of reconstruction is one of the focuses of future research. In this review, the concept of the proximal medial humerus column, the role of maintaining internal fixation, the role of biomechanics and the reconstruction methods are reviewed.

中医以辨证论治为基本的诊疗原则,遵循人与自然是一个有机整体的观念,但是缺乏解释其作用机制的客观分子生物学依据.Wnt/β-连环蛋白(β-catenin)信号通路是骨代谢研究史上的重大发现,是研究中医药防治骨质疏松症(Osteoporosis,OP)及探索中医药分子作用机制的关键点和突破点,从脾肾论治OP的效应可通过该信号通路所传递的信号表达.基于此,文章将从OP的病因、发病机制和治法方药方面对骨代谢过程中Wnt/β-catenin信号通路调控的影响展开综述,为中医治疗OP提供生物学依据.

Background: Knee osteoarthritis (KOA) is a degenerative disease, making a unique contribution to chronic pain, edema, and limited mobility of knee joint. This disease is an important factor affecting the quality of life of middle-aged and elderly people. Complementary and alternative medicine (CAM) therapies have been used clinically to treat KOA; however, the selection strategies of different CAM interventions in clinical practice are still uncertain, and the purpose of this study is to evaluate the efficacy and acceptability of different CAM therapies using systematic review and network meta-analysis. Methods: According to the strategy, the authors will retrieve a total of 7 electronic databases by October 2020, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chongqing VIP, and Wan-fang databases After a series of screening, 2 researchers will use Aggregate Data Drug Information System and Stata software to analyze the data extracted from the randomized controlled trials of CAM therapies for the KOA. Finally, the evidence grade of the results will be evaluated. Results: This study will provide a reliable evidence for the selection of CAM therapies for KOA. Conclusion: The results of this study will provide references for evaluating the influence of different CAM therapies for KOA, and provide decision-making references for clinical research. Ethics and dissemination: This study does not require ethical approval. The results will be disseminated through a peer-reviewed publication. OSF registration number: DOI 10.17605/OSF.IO/GJMF4.

Background: Poststroke depression (PSD) is an important complication of stroke, resulting in increased disability and mortality, which is a great threat to stroke survivors and public health. Complementary and alternative medicine (CAM) therapies is widely used in the treatment of PSD, However, the selection strategies of different CAM approaches in clinical practice is still not clear, and the purpose of this protocol is to compare the efficacy and acceptability of different CAM therapies using systematic review and network meta-analysis. Methods: According to the strategy, the authors will retrieve a total of seven electronic databases by August 2020, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chinese Scientific Journals Database, and Wan-fang databases. The network meta-analysis will be performed using Aggregate Data Drug Information System 1.16.8 and Stata 13.0 software. In addition, the Cochrane Collaboration's tool is employed for the methodological quality, and the quality of evidence will be evaluated according to the Grading of Recommendations Assessment, Development, and Evaluation system. Results: This study will provide a reliable evidence for the selection strategy of CAM therapies for PSD. Conclusion: The results of this study will provide references for evaluating the effects of different CAM therapies on PSD, and provide decision-making references for clinical practitioners, patients, and health policy makers. Ethics and dissemination: This study does not require ethical approval. the results will be disseminated through a peer-reviewed publication. OSF registration number: DOI 10.17605/OSF.IO/TNGH6.