Objective To understand the prevalence,treatment and influence factors of hypertension in maintenance hemodialysis (MHD) patients in Anhui Province.Methods A total of 2724 adult patients on MHD from January 1st 2014 to March 31st 2014 in 26 hospitals of southern,northern and central Anhui Province were investigated.Their demographic characteristics,primary disease,complications,medications,dialysis and laboratory examination were explored.The prevalence treatment rate and control rate of hypertension were analyzed.Associated factors for controlling hypertension [systolic blood pressure (SBP) ＜ 140 mmHg and diastolic blood pressure (DBP) ＜ 90 mmHg] were assessed by logistic regression analysis.Results (1) The prevalence of hypertension in the hemodialysis patients was 87.0％.Their treatment rate and control rate were 93.2％ and 23.9％ respectively.The average of SBP was (145.90±21.18) mmHg,and the DBP on average was (83.60± 12.21) mmHg.The most commonly used anti-hypertensive drug is calcium channel blocker (88.2％).Over one third (45.7％) of patients were treated with two kinds of anti-hypertensive drug,26.2％ with 1 kind,21.7％ with 3 kinds,and 6.4％ with 4 kinds or more.(2) Compared with non-hypertension patients,patients with hypertension have older age,higher body mass index (BMI),phosphorus,SBP and DBP,as well as lower hemoglobin and Kt/V (all P ＜ 0.05).(3) The multivariate logistic regression analysis showed that Ca ＞ 2.50 mmol/L (OR=2.084,95％CI 1.008-4.307,P=0.047) positively correlated with controlling hypertension,while smoke (OR=0.594,95％CI 0.356-0.911,P=0.046) and BMI 18.5 ～ 23.9 kg/m2 (OR=0.516,95％CI 0.293-0.907,P=0.022) negatively correlated with it.Conclusions High prevalence yet low control rate of hypertension in MHD patients in Anhui Province were observed.Hypocalcemia may be a protective factor for hypertension control,while smoke and BMI may be risk factors for it.

目的 了解维持性血液透析(maintenance hemodialysis,MHD)患者血管钙化情况及相关影响因素分析.方法 记录72例MHD患者人口学特征、临床及实验性检查资料,根据腹主动脉钙化评分(abdominal aortic calcification score,AACs)分为无钙化/轻度钙化组和中重度钙化组.检测血钙、血磷、碱性磷酸酶(alkaline phosphatase,ALP)、C反应蛋白(C reactive protein,CRP)、全段甲状旁腺激素(intact parathyroid hormone,iPTH)、血清骨硬化蛋白、白介素(interleukins,IL)-37水平.结果72例患者中有无钙化19例、轻度钙化11例、中度29例、重度13例.中重度钙化组年龄、透析龄、血钙、血磷、ALP、CRP及iPTH水平高于无钙化/轻度钙化组,差异均具有统计学意义(均有P ＜0.05).中重度钙化组血清骨硬化蛋白、IL-37水平高于无钙化/轻度钙化组,差异均有统计学意义(均有P＜0.05).Logistic回归分析结果显示高龄、高血钙、iPTH水平增加是MHD患者腹主动脉中重度钙化的独立危险因素(均有P＜0.05).结论 MHD患者普遍存在血管钙化,对血管钙化相关影响因素分析研究可能为血管钙化防控提供新靶点.

Objective To understand the quality of life（QOL）and its influencing factors in maintenance hemodialysis patients（hemodialysis maintenance,MHD）,and to provide theoretical basis for improving QOL of patients.Methods A cross-sectional study was conducted in the blood purification centre in 8 hospitals in Hefei,and patients’clinical data were collected.KDQOL-SF self-ad-