8月26—28日，由中华医学会、中华医学会临床流行病学和循证医学分会、中国临床流行病学工作网（ChinaCLEN）主办，上海市医学会、上海市医学会临床流行病学与循证医学分会、复旦大学循证医学中心承办的中华医学会第二十届全国临床流行病学和循证医学学术会议暨中华医学会临床流行病学和循证医学分会成立30周年纪念以线上会议的形式成功举办。

Objective To summarize results of the correlation of tumor necrosis factor-α (TNF-α) promoter-308A/G polymorphism with systemic lupus erythematosus (SLE) susceptibility in Chinese populations.Methods We collected all the publications about the correlation between TNF-α promoter-308A/G polymorphism and SLE in Chinese populations by searching PubMed,EBSCO,CBM,CNKI and Wanfang Data before the date of March 20,2010.Meta-analysis was performed for checking the difference between two groups about genotypes such as AA versus GG,GA versus GG,AA versus GG+GA,GA+AA versus GG,and A allele versus G allele.Results A total of 8 studies involving 731 SLE patients and 901 healthy people were included.The meta-analysis of total populations showed that,there was no significant correlation between A allele and increased SLE risk (OR=1.42,95%CI 0.97 to 2.09,P=0.07);the meta-analyses of populations in different regions showed there was no significant correlation of A allele and increased SLE risk in Chinese Taiwan populations (OR=1.04,95%CI 0.77 to 1.40,P=0.82).Moreover,there was no significant difference between SLE group and control group in the genotypes of AA versus GG,GA versus GG,AA versus GG+GA,and GA+AA versus GG.Conclusion This meta-analysis dosen't demonstrate the correlation between TNF-α promoter-308A/G polymorphism and SLE in Chinese populations.