Objective To research the influence of Qiangxin Tongmai capsule on blood dynamics, neural endocine hornmone and the expression of AQP2 mRNA in kidney of rat models with congestive heart failure (CHF). Methods Rat models with congestive heart failure were preparationed by ligating left coronary artery. Heart functions were observed after six weeks. The level of ANP and ET-1 were mensurated by radioimmunology assay and the expression of AQP2 mRNA in kidney was mensurated by RT-PCR. Results Blood dynamics parameters, ANP, ET-1 and AQP2 mRNA of the rat models were evidently abnormal compared to control group by false operated. Qiangxin Tongmai capsule can evidently improve these abnormalities. Conclusion The blood dynamics parameters, ANP, ET-1 and AQP2 mRNA of rat models preparationed by ligating left coronary artery were evidently abnormal. Qiangxin Tongmai capsule exerts anti-heart failure effect by improving the level of blood dynamics parameters, ANP, ET-1 and AQP2 mRNA in kidney of rat models.