To explore the possibility of developing a mathematical prediction of the risk of developing hypertension in men based on data from the anthropometry and somatometry surveyed 102 people with arterial hypertension and 49 people with normal levels of blood pressure. The examination included clinical, instrumental, functional and laboratory methods of examination and anthropometry with subsequent somatotropine. It was found that obtained by the results of mathematical modeling predictive nomograms can be used to determine the risk of developing hypertension. The use of prognostic nomograms allows with a probability of 70 % and above to predict the possibility of developing hypertension and highlight the leading factors that determine the presence of the subject at high risk, and acting on them, to prevent development of the disease. Forecast of development of arterial hypertension in patients with different levels of blood pressure using the method of restructuring and analysis of different types of statistical data, more than adequate based on the data anthropometry and somatometry.

Проведен анализ результатов реабилитационных мероприятий с применением пелоидотерапии низких температур при подагре с коморбидной патологией с учетом применения фармакологических препаратов. Обследовано 242 пациента обоего пола (средний возраст: 49,6 ± 4,4 года) с подагрой в сочетании с ишемической болезнью сердца (ИБС), артериальной гипертонией (АГ), сахарным диабетом (СД) и ожирением, проходивших лечение в стационаре краевого ревматологического центра г. Красноярска. Проведено комплексное обследование больных, подбор фармакологических препаратов с оценкой их эффективности, побочного действия, влияние на уровень мочевой кислоты (МК). Из числа обследованных 112 больных с ИБС и АГ было направлено на реабилитационное лечение (курорт «Озеро Учум» Красноярского края). Установлено, что курсовое лечение с применением грязевых аппликаций 26–28 °С у больных подагрой с сопутствующей ИБС, стабильной стенокардией I–II функционального класса (ФК) не уступает по эффективности грязевым аппликациям стандартных температур, оказывая локальное анальгезирующее, противовоспалительное действие, улучшая локомоторную функцию опорно-двигательного аппарата. Использование пелоидов низких температур (26–28 °С) в лечении данной категории больных позволяет иначе оценивать градиент температурного фактора и придавать особое значение химическим компонентам пелоидов. Поиск новых подходов в лечении и реабилитации больных данного профиля имеет практическое значение в целом для клинической медицины. Важно, чтобы фармакотерапия в каждом отдельном случае была оптимальной, метаболически безопасной, снижала риск кардиоваскулярных осложнений и улучшала качество жизни пациента с подагрой.

To study the frequency and gravity of disturbing-depressive disorders and their relationship to quality of life in the hearing impaired migrants Extreme North in the period of re-adaptation to new climate conditions, were examined 80 patients of both sexes who had previously resided in the Far North and moved further on permanent residence in Central Siberia, with arterial hypertension, the average age 64,1 years. Conducted a comprehensive audiological examination. Using special questionnaires were evaluated the severity of anxiety-depressive disorders and determined the levels of quality of life. It is established, that in the structure of sensorineural hearing loss more than a third of patients had a sensorineural hearing loss of the II degree. On a scale HADS anxiety symptoms were detected in more than 43% of the surveyed patients with sensorineural hearing loss, and depression symptoms more than half 51%. A summary indicator of quality of life in the hearing impaired migrants Far North totaled -5,24±0.67 points that correspond to the moderate decline in the quality of life, while among persons with clinically severe anxiety, and depression met the greatest number of patients with significantly reduced quality of life.

The article presents the results of studies of the anxious and depressed characteristics in elderly migrants of the Far North with arterial hypertension in the period of their stay in new climatic conditions with regard to their North experience, gender, age and timing of rehabilitation. There was a high frequency of disturbing-depressive symptomatology of the surveyed migrants in the Far North, the frequency and severity of which increases with age; women migrants of Far North are prone to depression 1,8 times, anxiety--3,2 times more often than men. With the increase of the period of stay in the new climate and geographical conditions, the severity and frequency of occurrence of anxiety and depression increase. The obtained results should be taken into account when building rehabilitation program and forecasting its effectiveness, while conducting psychotherapy and psychological prevention in this group of patients.

С целью изучения частоты и выраженности тревожно-депрессивных расстройств и их взаимосвязи с качеством жизни у мигрантов Крайнего Севера с артериальной гипертонией в период реадаптации к новым климатическим условиям было обследовано 145 пациентов обоего пола, проживавших ранее на Крайнем Севере и переехавших в дальнейшем на постоянное место жительства в Центральную Сибирь, средний возраст 64,1 ± 0,9 года. Обследование включало: общий клинический осмотр, регистрацию ЭКГ, анкетирование, двукратное измерение АД, биохимическое определение липидов и глюкозы крови. С помощью специальных опросников оценивалась тяжесть тревожно-депрессивных расстройств и определялись уровни качества жизни. Установлено, что симптомы тревоги выявлялись более чем у 42,7 % обследуемых мигрантов Крайнего Севера, а симптомы депрессии более чем у половины – 53,1 %. Суммарный показатель качества жизни у мигрантов Крайнего Севера составил 5,27 ± 0,39 балла, что соответствовало умеренному снижению качества жизни, при этом среди лиц с клинически выраженной тревогой и депрессией встречалось наибольшее количество пациентов со значительным снижением качества жизни.

To study the adherence to treatment of arterial hypertension among elderly women were surveyed 969 women, Krasnoyarsk aged 20 to 79 years, mean age 38,0±0,4 years. The proportion of the target over the age of 60 years was 8,4%. The examination included: General clinical examination, questionnaires, blood pressure measurement, ECG registration. Adherence to hypertension treatment was assessed by the conventional method Morisky-Green. Criteria of efficiency of treatment of hypertension (control), was the achievement of target levels of blood pressure less than 140/90 mm rt. art. Among patients in the older age group is more common arterial hypertension 2, 3 degrees and isolated systolic hypertension in comparison with the young. Awareness and adherence to treatment in this group of patients is higher than among young women, however, the achievement of target levels of blood pressure remains at a low level. The greatest commitment to treatment were detected in elderly patients with a high level of education.

To study the features of influence components of a metabolic syndrome on the clinical course of coronary heart disease at men taking into account components of body weight and a somatotip, 137 men, residents of Krasnoyarsk (middle age of 54,9±1,4 years) with an arterial hypertension and coronary heart disease are examined. Inspection included clinical, tool, functional and laboratory methods of research, and also anthropometry with the subsequent somatotipirovaniye. It is established that among men the metabolic syndrome met coronary heart disease at 10,8% examined. Patients with coronary heart disease in combination with the accompanying arterial hypertension had higher levels of a glycemia, an insulinemiya and lipids, than at patients with coronary heart disease without the accompanying arterial hypertension. Indicators of carbohydrate and lipidic exchanges at patients with coronary heart disease with a myocardial infarction in the anamnesis are higher in comparison with patients with coronary heart disease without the postponed myocardial infarction. Among the examined men somatotipa met with considerable development fatty components most more often.

To study re-adaptation to new climatic conditions, depending on the length of stay in the Far North. The study involved 2,137 men organized population of the city of Norilsk aged 30 54 years, mean age 45,8±1,3 years, the examinees were divided into groups depending on the length of stay in the Far North (10 years and over 10 years). Use of modern methods of epidemiological studies according to the WHO recommendations, we measured hemodynamic parameters, conducted a statistical analysis. The prevalence of hypertension in an organized newcomer populations of men aged 30-54 years was 35.6%, and those living in the region for less than 10 years 22.7%, more than 10 years, 44.2% (р=0,023). Observation of the Far North migrants who have come to a new place of residence, in the central part of Eastern Siberia, showed that the severity of hypertension during rehabilitation more often for longer stays 10 years and over. The cause of hypertensive crises, frequent angina was caused by the same high neuroticism, the socio-economic factors.

We studied the efficacy and safety of phenazepam administration as a component of combination therapy in 60 patients with coronary artery disease and acute myocardial infarction (AMI) complicated by cardiac arrhythmias. Our data showed that standard cardiotropic drug therapy combined with phenazepam administration in a daily dose of 1 mg led to significant decrease in the number of supraventricular and ventricular extrasystoles, decrease in the levels of anxiety and depression, and improvement in sleep quality in AMI patients. In contrast, we did not find significant improvement in above mentioned parameters in the control group of AMI patients who did not take phenazepam.

For studying carbohydrate metabolism of men of different somatotypes, with arterial hypertension and men with coronary heart disease, we provided 129 persons aged 30 to 59 with medical examination. We implemented the technique of somatometry, having carried out glucose tolerance test, and defined the levels of insulin immune reactivity. In the course of anthropometric study among men with coronary heart disease, muscle type was the most frequent. We marked heterogeneous correlations between the levels of insulin, glycemia and anthropometric indices of abdomen and indefinite somatotypes of men with arterial hypertension and of abdomen and muscle somatotypes of men with coronary heart disease. Men of muscle and thoracal somatotypes with arterial hypertension have low interconnections of the studying indices.

For studying the state of carbohydrate metabolism in men of different somatotypes, arterial hypertension patients, we examined 89 men aged 30 to 59 years. We used the methods of somatometry, glucose tolerance test, and defined the levels of insulin immune reactivity. In the antropometric study in men, arterial hypertension patients, abdominal type was the most frequent. The smallest levels of diastolic arterial pressure in men, arterial hypertension patients, were revealed in thoracal somatotype men, at the same time according to the levels of systolic arterial pressure in people of different somatotypes we didn't reveal any differences. We marked heterogeneous correlation ties between the levels of insulin, glycemia and antropometric indices in men, arterial hypertension patients, of different somatotypes, which were the most expressed in men of abdomen and indefinite somatotypes. Men о f muscle and thoracal somatotypes had smaller level of interconnections of the studied indices.

Aimed at studying the state of carbohydrate metabolism in men of different somatotypes having coronary artery disease we examined 79 men aged from 30 to 59 years. The technique of somatometry was used, glucose tolerance test was performed, levels of insulin immune reactivity were assessed. Heterogeneous intercorrelations between levels of insulin, glycemia and anthropometric indices in men of different somatotypes which were mostly expressed in men of abdominal and muscular somatotypes. Men of indefinite and thoracic somatotypes had smaller level of intercorrelations between the indices studied.