Objective:To understand the molecular epidemiological features of norovirus outbreaks in Shenzhen of China from January 2019 to December 2021.Methods:The norovirus outbreaks information and specimen from January 2019 to December 2021 were collected. Norovirus was detected by real-time reverse transcriptase polymerase chain reaction (RT-PCR). Positive samples were amplified by RT-PCR and sequenced. The sequences were then analyzed. Genome amplification and sequence analysis were performed on three strains of GII.2 [P16].Results:From January 2019 to December 2021, a total of 246 outbreaks caused by norovirus were reported, mainly in kindergartens (132, 53.66%) and primary schools (52, 21.14%). The number of cases in an outbreak ranged from 3 to 130, with a median value of 8. The epidemic peak of norovirus outbreak was from November to the next March. The viruses in 211 outbreaks were successfully genotyped. Seven genotypes of GI group and eleven genotypes of GII group were detected. Norovirus GII.2[P16] was responsible for 78 (36.97%) outbreaks. According to the genome analysis of GII.2[P16], the strains from the outbreaks in 2020 still belonged to GII.2[2016](2016-2017) subcluster. Amino acid mutations were observed in the non-structural protein P22 (L777S) and 3C protease (A1047V and P1074T).Conclusions:GII.2[P16] was the predominant genotype that caused the outbreak of norovirus in Shenzhen from January 2019 to December 2021, mainly in kindergartens and schools. Continuous surveillance and genome analysis can help to find the mutations of epidemic strains and the emergence of novel variants.

目的：了解IL-6在川崎病(KD)发病中的作用及意义。方法：采用酶联免疫吸附法测定血清IL-6水平；采用速率散射比浊法测定血清免疫球蛋白(IgG、IgA、IgM)的水平；用心脏彩超测定患儿冠状动脉内径。结果：KD急性期患儿血清IL-6及IgG水平均明显高于对照组(P＜0.05)；而IgA、IgM及恢复期IL-6水平接近于正常对照(P＞0.05)；KD患儿冠状动脉内径与急性期及恢复期血清IL-6水平均成正相关(r=0.414,P=0.0494;r=0.605,P=0.003)。结论：血清IL-6是KD急性期血管炎症变化重要介质，在KD发病机制中起重要作用；血清IL-6的升高与冠状动脉扩张或瘤形成可能相关。