Objective To explore the effect of early development training on infant neuropsychological development,demonstrating,and popularize the education mode of demonstration and individualized,Thereby promoting early child development. Methods A total of 71infants of early education group and 70infants of control group were regularly followed up within 12months.During follow-up,Gesell developmental scale was used at 6months,9months,12months of age,and the developmental quotient(DQ)were analyzed between early education group and control group. Results At 9months of age,both fine motor DQ and language DQ of early education group were significantly higher than control group(P0.05).At 12months of age,the fine motor DQ,language DQ,and social adaptation DQ of early education group were significantly higher than control group(P0.05). Conclusions The early development training can promote infant neuropsychological development,fine motor and language were more dependent on environmental stimulation,and the demonstration and individualized education mode of early child development was a long-term and positive significance.

目的 观察促性腺素释放激素类似物 （GnRH A）对特发性中枢性性早熟 （ICPP）女孩生长和预测成年身高的影响。方法 19例ICPP女孩 （6至 11岁 ）用GnRH A缓释剂 5 0～ 6 0 μg/kg ,4周注射一次 ,起始治疗年龄为 （8.5± 1.1）岁 （6～ 11）岁 ,治疗时间平均 11个月 （6～ 31个月 ）。观察治疗后性征和生长的改变 ,分析对骨龄的身高标准差分值 （SDS）增长 （HtSDSBA）和预测成年身高的增长（按靶身高SDS计 ,PHtSDSTHt）。结果 治疗后血清雌激素水平降低 ,乳房退缩 ,生长减速至青春前期速度。骨龄显著受抑 ,表现为骨龄增长 /年龄增长比值为 0 .6± 0 .2 ,HtSDSBA从治疗前 - 1.45±0 .6 4增加至 - 1.0 5± 0 .5 9（P ＜0 .0 5 ） ,PHtSDS从治疗前 - 0 .99± 0 .83增加至 - 0 .0 9± 0 .90 （P ＜0 .0 1） ,预测身高增长值与疗程呈显著正相关 （r =0 .82 ,P ＜0 .0 1）。结论 GnRH A能显著有效地抑制性征发育和骨龄增长 ,经合理和足够疗程能减少ICPP女孩身高年龄 骨龄 年龄间差距而改善预测成年身高。