Coronary heart disease（CHD） is based on atherosclerosis（AS）, which belongs to the categories of ‘chest pain’ or ‘chest obstruction’ in Traditional Chinese Medicine（TCM）. Based on the pathophysiological mechanism of CHD in modern medicine, combined with the understanding of the etiology and pathogenesis of TCM, it is found that the key pathogenesis of CHD is ‘blood stasis’ and ‘toxin’ mutual integration. By discussing the connotation and origin of the theory of blood stasis and toxin, the article summarized the pathogenic characteristics of the pathogenesis of the interaction of blood stasis and toxin in atherosclerotic diseases and organized the progress in clinical application and basic research of the method of activating blood circulation and detoxifying, which provides ideas of combining disease and syndrome for the prevention and treatment of atherosclerotic diseases represented by CHD with integrated TCM and western medicine.

病毒性心肌炎是小儿较为常见的一种疾病,由于儿童机体发育未成熟,易患病且易产生危重症,应及时诊治.目前,现代医学目前仍缺乏特效药物,中医药治疗可获得良好的临床疗效.本研究从"虚"与"毒"两个方面探讨小儿病毒性心肌炎的病机与辨治,以期为中医临床诊治提供参考.

BackgroundPatients with metabolic syndrome (MetS) have increased cardiovascular risk. Capsaicin (CAP) has been shown to reduce lipids, but efficacy for patients with MetS is unknown.MethodsA systematic review was performed according to PRISMA guidelines, to compare the effects of CAP against a placebo. Differences in the weight mean difference (WMD) with 95% confidence intervals (95% CI) were then pooled using a random effects model.ResultsNine randomized controlled trials including 461 patients were identified in the overall analysis. CAP significantly decreased total cholesterol (TC) (WMD = −0.48, 95% CI: −0.63 to −0.34, I2= 0.00%) and low-density lipoprotein cholesterol (LDL-C) (WMD = −0.23, 95% CI: −0.45 to −0.02, I2 = 68.27%) among patients with MetS. No significant effects of CAP were found on triglycerides (TG) or high-density lipoprotein cholesterol (HDL-C) (WMD = −0.40, 95% CI: −1.50 to 0.71, I2 = 98.32%; WMD = −0.08, 95% CI: −0.21 to 0.04, I2 = 86.06%). Subgroup analyses indicated that sex and intervention period were sources of heterogeneity. The results revealed that CAP decreased TG levels in women (WMD = −0.59, 95% CI: −1.07 to −0.10) and intervention period <12 weeks (WMD = −0.65; 95% CI: −1.10 to −0.20). And there was no potential publication bias according to funnel plot, Begg' test and Egger regression test.ConclusionsCAP supplementation is a promising approach to decreasing TC and LCL-C levels in patients with MetS. However, short-term (<12 weeks) use of CAP in women may also reduce TG levels.Systematic Review RegistrationIdentifier: CRD42021228032.

目前,临床上冠心病睡眠障碍越来越常见,严重影响疾病的发展和预后.心主神明,具有藏神功能,是睡眠正常的关键.一旦"心藏神"功能失常,机体阴阳失衡便会发生睡眠障碍.现基于"心藏神"理论,探析冠心病睡眠障碍的病机,并据此提出清心泻火、交通心肾,化痰降浊、宁心安神,活血化瘀、清热解毒,养血和血、护心安神,温补心阳、顺应四时等相应治法及方药,从而为临床中医药诊治冠心病睡眠障碍提供更好的理论支持.