ObjectiveTo investigate the feasibility, accuracy, and safety of using a 3D-printed navigating template in transforaminal lumbar intervertebral fusion (TLIF) for treating lumbar spinal stenosis (LSS).MethodsA retrospective analysis was conducted on single-segment lumbar vertebrae treated with TILF at Beijing Ditan Hospital between May 2023 and May 2024. Clinical data were collected from patients diagnosed with LSS. Among them, 36 patients who underwent surgery using a 3D-printed navigating template were assigned to the template group, while another 36 patients with similar baseline characteristics were included in the control group. The following parameters were recorded: operative time, blood loss, frequency and duration of fluoroscopy, accuracy of screw placement, and incidence of complications related to spinal cord or nerve injuries.ResultsThe operation time and blood loss in the template group were significantly lower than those in the control group (P < 0.05). The fluoroscopy time and frequency on the template side were also significantly lower than those on the puncture side and in the control group (P < 0.05). Notably, there were no grade 2 screws observed in the template group, whereas 14 grade 2 screws were identified in the control group. Furthermore, the proportion of grade 0 screws on both sides in the template group was significantly higher compared to the control group (P < 0.05). However, no statistically significant difference was observed between the two sides within the template group (P > 0.05). Additionally, none of the patients experienced complications such as spinal cord or nerve injury.ConclusionThe application of 3D-printed navigating templates in the treatment of LSS using TLIF is feasible. Despite the need to account for potential inaccuracies caused by skin movement and changes in body position during surgery, this technique represents a novel and viable minimally invasive approach for screw placement.

Background: With the increasing life expectancy of people living with HIV (PLWH) following antiretroviral therapy (ART), there is a growing prevalence of chronic diseases such as osteonecrosis of the femoral head (ONFH). Compared with the more accessible blood, the viral infection profile in bone marrow and necrotic femoral heads in PLWH remains inadequately characterized. Methods: Femoral head and bone marrow were collected from 15 PLWH undergoing total hip arthroplasty. For each femoral head, samples were obtained from the subchondral, necrotic, sclerotic, and normal areas. HIV DNA and HIV RNA assays were employed to evaluate disparities in viral load and reservoir between bone marrow and blood, as well as to quantify viral infection in distinct regions of the necrotic femoral head. Results: Blood HIV RNA dropped below detectable levels in 8 patients (below 20 copies/mL). The median of bone marrow HIV RNA was 255.89 copies/mL. HIV DNA in blood and bone marrow was 296.35 and 454.31 copies/106 cells. HIV DNA in necrotic area was about half that in sclerotic area, HIV RNA was about twice that in normal area, the difference was statistically significant. Conclusion: Despite using ART, there is still substantial active HIV and a potential reservoir in the bone marrow. Viral transcription was most active in the necrotic area of the femoral which indicate that HIV itself is involved in ONFH.

The coronavirus disease (COVID-19) SARS-CoV-2 virus epidemic continues to exhibit a sporadic onset trend due to the continuous variation of the novel coronavirus. However, the psychological impact of the pandemic persists. It is crucial to reflect on our experiences to better prepare for future large-scale infectious diseases. During outbreaks of infectious diseases, patients may still require orthopaedic surgery. It is crucial to prioritize the safety of medical staff and establish procedures to ensure their protection. However, with the implementation of a series of standardized operational protection procedures, orthopaedic surgeons can safely perform their duties without the risk of contracting COVID-19. There is no doubt that the orthopaedic occupational exposure protection process and perioperative management plan for global infectious diseases, such as COVID-19, require a standardized summarization process and a narrative review.

In order to effectively improve the effectiveness and rationality of the evaluation of power material suppliers, a supplier evaluation model is designed based on the improved fuzzy comprehensive evaluation method. Firstly, corporate social responsibility dimension is introduced on the basis of exist

This study aims to investigate the feasibility and effectiveness of enhanced recovery after surgery (ERAS) in HIV-positive patients diagnosed with osteonecrosis of the femoral head (ONFH) undergoing total hip replacement (THR). We retrospectively included 80 HIV-positive patients diagnosed with ONFH who underwent THR between 2011 and 2022. Forty patients treated before August 2019 constituted the control group, receiving standard antiviral regimens and traditional perioperative management pathways. The remaining 40 patients, treated after August 2019, formed the study group, which followed the ERAS protocol. This protocol emphasized the use of more effective antiviral medications, rapid viral load reduction, immune enhancement, improved nutritional status, control of co-infections, prophylactic antibiotics, and anti-osteoporosis measures. We recorded patients' general status and imaging examinations before surgery, as well as detailed perioperative management strategies, antiviral regimens, durations, and immunological indicators for both groups. Targeted and standardized treatment measures were applied to the ERAS group, allowing for a comparison of the efficacy of perioperative management between the two patient groups. Preoperative nutritional and immune indicators were lower in the control group than in the study group, while inflammatory markers were higher. Postoperatively, immune, nutritional, and inflammatory indicators were significantly better in the ERAS group compared to the control group. Following antiviral treatment, the viral load was predominantly undetectable in the ERAS group (target not detected, TND). Comprehensive measures minimized complications in the ERAS group (P = 0.028, P < 0.05). The hospitalization duration for the ERAS group was significantly shorter than that of the control group, with both groups showing marked improvement compared to preoperative conditions and no incidents of loosening or dislocation. Strengthening antiviral treatment, anti-infective strategies, incision care, and nutritional support effectively prevents and reduces complications such as delayed wound healing in HIV-positive patients. The implementation of ERAS measures requires careful attention to the patient’s immune status, close monitoring of clinical changes, and timely adjustments to treatment and care plans. Treatment studies.

BACKGROUND:In the post-epidemic era, Acquired Immune Deficiency Syndrome (AIDS) remains one of the most prevalent and detrimental infectious diseases worldwide. The incidence of osteonecrosis of the femoral head (ONFH) in AIDS patients is 100 times higher than that in healthy individuals. Although Total Hip Arthroplasty (THA) is ultimately necessary for most patients, there is still a dearth of evidence regarding its safety and efficacy in Chinese AIDS patients. METHODS:The clinical data of 49 patients who met the inclusion and exclusion criteria were retrospectively analyzed. Simultaneously, we categorized patients whose hemoglobin and albumin met a specific threshold as the optimized group and performed group comparisons. RESULTS:There are statistical differences in Harris score and VAS score pre- and post-operation, with a low overall complication rate. Notably, no disparities were observed between the optimized group and the partial optimized group in terms of overall conditions, laboratory examination indicators, severity of ONFH, surgical outcomes, surgical complications, pain perception or functional limitations. Furthermore, no correlation was found between CD4+ T lymphocytes and hemoglobin levels, albumin levels, white blood cell count, or platelet count. CONCLUSION:THA is safe and effective in Chinese AIDS patients with ONFH. However, optimal treatment has limited efficacy in AIDS patients undergoing THA for ONFH. The reconsideration and evaluation of the predictive value of CD4+ T lymphocytes for postoperative complications in joint replacement procedures is warranted.

Background. The incidence of osteonecrosis of the femoral head (ONFH) in people with human immunodeficiency virus (HIV) is 10-100 times higher than that in the general population. However, the specific bone microstructure and extent of damage within the femoral head in PWH are still unclear. Methods. Femoral head samples were obtained by total hip arthroplasty, micro-computed tomography (micro-CT) was employed to investigate the microstructure of trabecular bone across 4 representative regions within necrotic femoral heads, and quantitative analysis was performed. Results. On general observation, different degrees of degenerative cartilage, fibrocartilage, hyperplastic bone, and exposed bone were presented alternately, with a "map-like" appearance. On micro-CT, compared with the normal and necrotic areas, the bone volume/tissue volume and bone mineral density of the sclerotic areas were significantly increased, the number of trabeculae was significantly increased, and the gap was smaller (P < .05). There was no significant difference in trabecular thickness among the groups (P < .05). Conclusions. The systemic immune syndrome caused by HIV itself may interfere with the normal metabolism of bone, including osteoblasts and osteoclasts, and thus participate in HIV-related ONFH.

The prevalence of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) has emerged as a major public health concern in China. When patients with HIV infection undergo surgical treatment, there are two main challenges. Firstly, medical staff face a high risk of HIV infection due to occupational exposure. Secondly, the patient’s immune function is impaired, increasing the risk of opportunistic infections and postoperative complications. The surgical treatment of such patients is unique, and the risk of occupational exposure during the operation primarily depends upon the viral load of HIV/AIDS patients. Therefore, perioperative antiretroviral therapy is of paramount importance in order to standardize the perioperative antiretroviral therapy (ART) for HIV/AIDS patients. The Surgery Group of the Chinese Association of STD and AIDS Prevention and Control, in collaboration with the Treatment Association, and Surgery Group of the Chinese Medical Association of Tropical Diseases and Parasitology, has developed an expert consensus on perioperative antiretroviral therapy for HIV/AIDS patients. This consensus encompasses various aspects, including surgical risk assessment, selection of perioperative antiretroviral therapy regimens, prevention of opportunistic infections, and the crucial focus on rapid preoperative viral load reduction and immune function reconstruction for HIV/AIDS patients.

Purpose:Our aim was to identify the clinical characteristics and develop and validate diagnostic and prognostic web-based dynamic prediction models for gastric cancer (GC) with bone metastasis (BM) using the SEER database.Method:Our study retrospectively analyzed and extracted the clinical data of patients aged 18-85 years who were diagnosed with gastric cancer between 2010 and 2015 in the SEER database. We randomly divided all patients into a training set and a validation set according to the ratio of 7 to 3. Independent factors were identified using logistic regression and Cox regression analyses. Furthermore, we developed and validated two web-based clinical prediction models. We evaluated the prediction models using the C-index, ROC, calibration curve, and DCA.Result:A total of 23,156 patients with gastric cancer were included in this study, of whom 975 developed bone metastases. Age, site, grade, T stage, N stage, brain metastasis, liver metastasis, and lung metastasis were identified as independent risk factors for the development of BM in GC patients. T stage, surgery, and chemotherapy were identified as independent prognostic factors for GC with BM. The AUCs of the diagnostic nomogram were 0.79 and 0.81 in the training and test sets, respectively. The AUCs of the prognostic nomogram at 6, 9, and 12 months were 0.93, 0.86, 0.78, and 0.65, 0.69, 0.70 in the training and test sets, respectively. The calibration curve and DCA showed good performance of the nomogram.Conclusions:We established two web-based dynamic prediction models in our study. It could be used to predict the risk score and overall survival time of developing bone metastasis in patients with gastric cancer. In addition, we also hope that these two web-based applications will help physicians comprehensively manage gastric cancer patients with bone metastases.

Background Most patients with insufficient bone mass suffer from severe horizontal or vertical bone defects in oral implant surgery. The purpose of this study was to compare the bone regeneration effects of titanium meshes with different porosity in the treatment of bone defects. Methods Nine beagle dogs were equally divided into three groups based on execution time. Three months after the extraction of the first to fourth premolars of the mandible, three bone defects were randomly made in the mandible. Bone particles and three kinds of three-dimensional (3D) printed titanium nets with different porosities (low porosity group (LP), 55%; medium porosity group (MP), 62%; and high porosity group (HP), 68%) were replanted in situ. The beagles were killed 4, 8, and 12 weeks after surgery. Formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with micro-CT, basic fuchsin staining, and toluidine blue staining. Results Micro-CT analysis showed that the trabecular thickness, trabecular number, and bone volume fraction of the HP group were higher than those of the other two groups. Moreover, the trabecular separation of the HP group decreased slightly and was lower than that of the MP and LP groups. Histological staining analysis showed that the trabecular number in the HP group was higher than in the other two groups at 8 and 12 weeks, and the bone volume fraction of the HP was higher than that in the other two groups at 12 weeks. Moreover, the trabecular thickness of the MP was higher than that of the LP group at 12 weeks and the trabecular separation was lower in the HP group at 4 and 8 weeks. The differences were statistically significant ( p < 0.05). Conclusion A 3D printed titanium mesh with HP in a certain range may have more advantages than a titanium mesh with LP in repairing large bone defects.

Abstract Objective To investigate the efficacy of treating patients with HIV-positive osteonecrosis of the femoral head using drilled decompression autologous bone marrow and allogeneic bone grafting. Methods 40 patients (44 hips) with early osteonecrosis of the femoral head treated by drilling decompression autologous bone marrow and allogeneic bone grafting since October 2015 were retrospectively analyzed, among which 20 patients (24 hips) were HIV-positive patients with early osteonecrosis of the femoral head, 16 males and 4 females, age 22–43 years, average 39.6 ± 10.18 years, and 20 patients (20 hips) in the same period HIV-negative early osteonecrosis of the femoral head patients, 13 males and 7 females, aged 48–78 years, mean 63.50 ± 7.94 years were negative controls. General information including ARCO stage, Harris score, VAS score, hematological indexes including CD4+ T lymphocyte count, and HIV viral load was recorded for all patients before surgery. All patients were operated on by drilling and decompression of the necrotic area, harvesting autologous iliac bone marrow with allogeneic bone, and bone grafting through the decompression channel. The patients were followed up regularly at 6, 12, and 24 months after surgery and annually thereafter, and the repair of the necrotic femoral head was observed by reviewing the frontal and lateral X-ray, CT or MRI of the hip joint, and the complications and functional recovery of the hip joint was counted and compared between the two groups. Results All patients were followed up, and the ARCO stages in the HIV-positive group were stage I 2 hips, stage IIA 6 hips, stage IIB 8 hips, stage IIC 6 hips, and stage III 2 hips, with a follow-up time of 12 to 60 months and a mean of 24.6 months. In the negative control group, there were 3 hips in ARCO stage I, 7 hips in stage IIA, 5 hips in stage IIB, 3 hips in stage IIC, and 2 hips in stage III, and the follow-up time ranged from 13 to 62 months, with an average of 24.8 months. The Harris score and VAS score of the hip in both groups improved significantly at 6 months postoperatively compared with those before surgery (P < 0.001). The difference between the Harris score of the hip in the positive group at 24 months postoperatively compared with that at 6 months postoperatively was statistically significant, but the VAS score at 24 months postoperatively compared with that at 6 months postoperatively was not statistically significant. In the negative group, there was no statistically significant difference in the Harris score and VAS score of the hip at 24 months postoperatively compared with those at 6 months postoperatively. In the positive group, there was a trend of continuous increase in hip BMD from the beginning of the postoperative period (P < 0.001). There was no statistically significant difference between the negative group and the positive group at the 24 months postoperatively follow-up except for the Harris score, which was statistically significant (P < 0.001), and the VAS score, which was statistically insignificant. At the 24 months postoperatively follow-up, patients in both groups had good recovery of hip function, and no complications such as vascular and nerve injury and fracture occurred during the perioperative period and follow-up period, and no complications related to incisional infection and pulmonary infection occurred during hospitalization. Conclusion The treatment of early HIV-positive osteonecrosis of the femoral head patients with autologous bone marrow and allogeneic bone grafting by drilling and decompression to remove the tissue in the necrotic area of the femoral head can effectively stop the process of osteonecrosis of the femoral head and promoting femoral head repair in HIV-positive patients is a safe and effective method for treating HIV-positive patients with early osteonecrosis of the femoral head, and can effectively delay or postpone total hip replacement in patients.

[目的]探讨后路行病灶清除,病椎置钉,椎间植骨融合内固定手术治疗腰椎单节段布氏杆菌脊柱炎的临床疗效.[方法]回顾性分析2016年11月—2019年12月,采用上述术式治疗21例腰椎单节段布氏杆菌脊柱炎患者的临床资料.[结果]所有患者均顺利完成手术,术中无严重并发症.平均随访时间(18.8±3.4)个月,随时间推移,VAS评分和ODI指数均显著减少(P＜0.05),而JOA评分显著增加(P＜0.05).21例患者术后病理HE染色均可见病变区有大量单核细胞、淋巴细胞等炎性细胞浸润,符合布鲁氏菌病改变,Gimesa染色均发现短球状布鲁氏菌.与术前相比,术后ESR、CRP和局部后凸Cobb角均显著降低(P＜0.05),而椎间隙高度显著增加(P＜0.05).末次随访时,影像学显示所有患者均获得骨性融合,未出现内固定松动、断裂等情况.[结论]后路病灶清除,病椎置钉椎间融合内固定可安全有效治疗腰椎单节段布氏杆菌脊柱炎.

Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), has become a heavy burden of disease and an important public health problem in the world. Although current antiretroviral therapy (ART) is effective at suppressing the virus in the blood, HIV still remains in two different types of reservoirs—the latently infected cells (represented by CD4+ T cells) and the tissues containing those cells, which may block access to ART, HIV-neutralizing antibodies and latency-reversing agents. The latter is the focus of our review, as blood viral load drops below detectable levels after ART, a deeper and more systematic understanding of the HIV tissue reservoirs is imperative. In this review, we take the lymphoid system (including lymph nodes, gut-associated lymphoid tissue, spleen and bone marrow), nervous system, respiratory system, reproductive system (divided into male and female), urinary system as the order, focusing on the particularity and importance of each tissue in HIV infection, the infection target cell types of each tissue, the specific infection situation of each tissue quantified by HIV DNA or HIV RNA and the evidence of compartmentalization and pharmacokinetics. In summary, we found that the present state of HIV in different tissues has both similarities and differences. In the future, the therapeutic principle we need to follow is to respect the discrepancy on the basis of grasping the commonality. The measures taken to completely eliminate the virus in the whole body cannot be generalized. It is necessary to formulate personalized treatment strategies according to the different characteristics of the HIV in the various tissues, so as to realize the prospect of curing AIDS as soon as possible.

Abstract Objective To evaluate the risk factors that affect wound healing after surgery of giant cell tumor in patients with human immunodeficiency virus (HIV). Methods 20 patients of giant cell tumor with HIV were recruited from June 2018 to June 2022, once diagnosed, 20 patients were receive timely HAART (Highly Active Antiretroviral Therapy) with China's first choice of national free HAART drug containing tenofovir disoproxil fumarate, lamivudine and efavirenz (TDF + 3TC + EFV, ). and 20 patients of giant cell tumor without HIV were enrolled as control at same time. All patients were underwent the same surgical method. Observe the incidence of infection at the surgical site and risk factors that affect wound healing were evaluated. Results The incidence of poor outcome of wound healing in HIV-positive group was higher than HIV-negative group (p < 0.05), but there was no significant difference in infection of the wound between two groups (p > 0.05). Multivariable regression analysis demonstrated that CD4 + T-lymphocyte count and clinical categories of HIV were independent risk factors for postoperative wound healing (p < 0.05), while age, gender, operation time,albumin,hemoglobin and combined disease, were not (p > 0.05). Conclusion The wound can be healed normally in most of HIV-positive patients with giant cell tumor, and the outcome of postoperative wound healing was significantly associated with CD4 + T-lymphocyte coun and HIV clinical category. At the same time, we recommended that reasonable perioperative adjuvant treatments, including nutritional support and immunomodulators, and anti-retroviral drugs should be used.

Background As a widespread back condition in orthopedics, spondylitis is rarely caused by Salmonella. Here, we report a rare case of spondylitis caused by Salmonella enteritis associated with Brucella melitensis. Case Presentation Salmonella septicemia was initially diagnosed in a 27-year-old woman with high fever and low back pain, but her symptoms did not improve after 3 days of antibiotic treatment. The patient was then referred to our hospital’s Department of Infectious Diseases. This patient had mild anemia. There were no positive results for tuberculosis antibody and Rose Bengal plate agglutination (RBPT). When the patient’s symptoms did not improve after diagnostic anti-tuberculosis treatment, he was transferred to our Orthopaedics department for lumbar posterior lesion removal, decompression, internal fixation, cage implantation, and bone grafting fusion under general anesthesia. Following the operation, a postoperative specimen culture and a real-time polymerase chain reaction (real-time-PCR) indicated Salmonella enteritis with Brucella melitensis (B. melitensis) infection. The symptoms improved and inflammatory markers returned to normal after 2 weeks of treatment with levofloxacin, rifampicin, and doxycycline. Conclusion Anaemic patients with immunocompromised conditions should be given special attention in the diagnosis of Salmonella spondylitis. Surgery should be considered if antibiotic therapy fails to identify the pathogen that is infecting the patient with infectious spondylitis.

BACKGROUND:Acquired immune deficiency syndrome and fracture are all serious hazards to human health that create a widespread alarm. Biomarkers that are closely linked to HIVRNA and fracture are unknown.METHODS:48 cases with HIV and fracture and 112 normal cases were recruited. Blood neutrophil count (NEU), white blood cell count (WBC), PAK1 and HIVRNA were measured. Pearson's chisquared test was used to evaluate the association between HIVRNA with fracture and NEU, WBC, PAK1. BP neural network model was constructed to analyze the predictive power of the combined effects of NEU, WBC, PAK1 for HIV RNA with fracture.RESULTS:There exist strong correlations between PAK1, NEU, WBC and HIVRNA with fracture. The neural network model was successfully constructed. The overall determination coefficients of the training sample, validation sample, and test sample were 0.7235, 0.4795, 0.6188, 0.6792, respectively, indicating that the fitting effect between training sample and overall was good. Statistical determination coefficient of the goodness of fit R2 ≈ 0.82, it can be considered that degree of fit between the estimate and corresponding actual data is good.CONCLUSION:HIVRNA with fracture could be predicted using a neural network model based on NEU, WBC, PAK1. The neural network model is an innovative algorithm for forecasting HIVRNA levels with fracture.

Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem cell proliferation is precisely controlled is still not fully understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun can be phosphorylated at multiple residues in vivo. Interestingly, we show that the phosphorylation among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important for its function in ISC proliferation regulation. Thus, our study unveils the important role of post-translational modification of Yun in stem cell proliferation.

Objective:To investigate the single-stage posterior surgery surgical treatment of lumbar brucellosis spondylitis combined with lumbar spondylolisthesis, and evaluate its clinical efficacy.Methods:The clinical data of 16 patients with lumbar brucellosis spondylitis combined with lumbar spondylolisthesis collected in Beijing Ditan Hospital, Capital Medical University from July 2015 to March 2019 were analyzed, retrospectively, including 14 males and 2 females, aged from 46 to 68 years old, with an average of (59.2 ± 6.5) years old, who were treated through one-stage posterior lumbar lesion removal, reduction, decompression, internal fixation, and bone graft fusion. The postoperative follow-up were 12 to 36 months, with an average of (25.0 ± 8.1) months. The reduction rate of spondylolisthesis, reduction loss rate, bone graft fusion rate and complication rate after surgery were recorded. At the same time, the visual analogue scale (VAS), the Japanese orthopaedic association scores (JOA), the oswestry disability index (ODI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rose bengal plate agglutination test (RBP) before and after the operation were compared to evaluate the clinical efficacy.Results:VAS score decreased from 8.0 (8.0, 8.8) preoperatively to 2.0 (1.3, 2.0) and 0.0 (0.0, 1.0) at 2 weeks and 1 year after operation, respectively. JOA score increased from the average (11.8 ± 3.6) preoperatively to (18.6 ± 2.3) and (23.6 ± 2.7) at 2 weeks and 1 year after operation, respectively. ODI index decreased from (88.5 ± 5.6) % preoperatively to (35.7 ± 3.1) % and (9.3 ± 5.7) % at 2 weeks and 1 year after operation, respectively. ESR decreased from 35.5 (14.5, 43.0) mm/h preoperatively to (12.9 ± 5.3) mm/h and (9.2 ± 3.6) mm/h at 2 weeks and 1 year after operation, respectively. CRP decreased from (20.3 ± 10.2) mg/L preoperatively to (7.6 ± 3.1) and (3.5 ± 1.7) mg/L at 2 weeks and 1 year the operation, respectively. Two weeks after surgery and one year after surgery, VAS, JOA, ODI, ESR and CRP were significantly different from those before surgery (all P < 0.001). Moreover, VAS, JOA, ODI, ESR and CRP were statistically different at 1 year after operation compared with 2 weeks after operation (all P < 0.001). The average reduction rate of spondylolisthesis 2 weeks after surgery was (91.2 ± 6.7)% and the median loss rate of reduction at 1 year after surgery was 8.0 (5.0, 9.8)%. During the last follow-up, all patients obtained bony fusion, no internal fixation loosening, displacement, breakage, etc and no recurrence occured.Conclusions:One-stage posterior lumbar lesion removal, reduction, decompression, internal fixation, and bone graft fusion are feasible for the treatment of lumbar brucellosis spondylitis combined with lumbar spondylolisthesis. The reconstruction of spinal stability could relieve pain, heal lesions and improve the ability to live independently.