目的 探讨银行职业人群血尿酸(SUA)水平与轻度非酒精性脂肪肝(NAFLD)的相关性,为银行职业人群NAFLD的监测和防治提供参考依据.方法 于2021年3-12月,选取南京某银行在职职工1 046人进行问卷调查、体格检查、实验室检测及肝脏B超检查.根据诊断标准,将研究对象分为轻度NAFLD组(256人)和对照组(790人),根据SUA四分位数水平将研究对象分为Q1～Q4组4组.采用SPSS 23.0和R 4.0.4软件进行t检验、秩和检验、x2检验和方差分析,采用多因素logistic回归模型、限制性立方样条及敏感性分析探讨SUA与NAFLD的相关性.结果 纳入研究对象1 046 人,其中男性551人,女性495人.轻度NAFLD的患病率为24.47％,其中男性(39.02％)高于女性(8.28％),差异有统计学意义(x2=133.275,P＜0.01).随着SUA水平的上升,研究对象轻度NAFLD的患病率呈上升趋势,有统计学意义(x2=117.531,Ptrend＜0.01).限制性立方样条分析结果显示,SUA水平与轻度NAFLD患病有显著的非线性剂量-效应关系(整体关联性检验:P-overall＜0.001;非线性检验:P-non-liner=0.031).多因素logistic回归分析结果显示,调整了混杂因素后,与Q1组相比,Q3组(OR=2.256,95％CI:1.107～4.595)和Q4组(OR=2.552,95％CI:1.214～5.367)轻度 NAFLD 的患病风险较高(P＜0.05).敏感性分析结果显示,调整了混杂因素后,与Q1组相比,正常体重人群Q4组(OR=20.306,95％CI:2.304～178.989)和剔除糖尿病人群Q4组(OR=2.837,95％CI:1.317～6.111)轻度NAFLD的患病风险更高(P＜0.05).结论 南京市某银行职业人群轻度NAFLD患病率较高,高SUA水平与该银行职业人群轻度NAFLD发生高风险相关.

Objective To evaluate the effectiveness of comprehensive lifestyle modification in the primary health care system on status of pre-chronic diseases in a conventional healthcare program.Methods Two hundred and twenty-nine adult volunteers in 5 conventional healthcare centers were divided into 4 groups:group of prehypertension(n=67),group of prediabetes(n=38),group of abnormity serum cholesterol(n=71)and group of osteopenia(n=53).A muhicomponent behavioral intervention including education,physical activity,dietary practice,cease smoke,calcium supplement and exposure to sunlight was conducted for 12 months.The main outcome of each group was blood pressure,blood glucose,serum cholesterol and bone mineral density.Results Over 12 months,compared with the status before intervention,participants in each group were statistically significantly improved,the mean net reduction in systolic BP/diastolic BP was 9.4 mm Hg/6.6 mm Hg(1 mm Hg=0.133 kPa,t=5.93/8.29.P＜0.05)in group of prehypertension;the reductions of blood glucose,serum cholesterol were 0.9 mmol/L(t=3.69,P＜0.05)and 0.5 mmol/L(t=4.09,P＜0.05)in group of prediabetes and group of abnormity serum cholesterol,and the increase of bone mineral density on lumbar spine was 0.015 g/cm2(t=2.03,P＜0.05)in group of osteopenia,Conclusions For chronic disease prevention,ater one year the comprehensive lifestyle intervention produced beneficial changes in diet,physical activity,and biochemical parameters.This type of intervention is a feasible option to prevent chronic disease and should be implemented in the primary health care system.

目的 分析职业人群常见慢性疾病(慢病)危险因素及健康知识知晓、健康信念持有、健康行为形成情况.方法 根据1027名南京市部分职业人员体重、血压、血糖、胆固醇及尿酸检测指标,评价该人群慢病过渡性危险因素暴露率;根据其中642人反馈的<个人健康信息调查表>,评价其慢病行为危险因素与健康知识知晓、健康信念持有、健康行为形成状况.结果 职业人群中主要慢病过渡性危险冈素检出位次为:血脂异常、体质指数上升、血压升高、尿酸异常、血糖升高等;主要行为危险因素为吸烟、过度饮酒、不合理饮食及体力活动缺乏.较好的健康信念持有率、健康知识知晓率、健康行为形成率(健康知信行)仅分别为11.55%,9.01%和14.65%.结论 职业人群慢性疾病危险因素暴露率较高,健康知信行水平较低,应引起重视.

Three hundred and ninety-five administrative staffs were randomly selected and provided health management to evaluate its effects in risk factors control of chronic diseases. At 1 year, the rate of people health knowledge and attitude were increased from 14.2% to 39.2%, 7.1% to 25.1%, P≤0.01 ; risk behavior exposure, including incorrect dietary intake, sedentary habit, alcohol consumption or smoking, reduced to some extent (P<0.05).