A 78-year-old man had previously undergone replacement of ascending aorta using gelatin-resorcinformalin(GRF) glue for acute aortic dissection. Five years later, a follow-up computed tomography(CT) showed an aortic root pseudoaneurysm. Ultrasound cardiography revealed moderate aortic regurgitation and pseudoaneurysm of aortic root. Aortic root replacement was planned based on a clinical diagnosis of an anastomotic pseudoaneurysm of the aortic root. The patient was discharged without complication 26 days after surgery. In the histopathological examination, the necrotic change of smooth muscle cells in the aortic media was revealed. Previous reports suggests that the use of GRF glue for reconstructing the dissected aorta results in higher rates of postoperative redissection or pseudoaneurysm. Therefore, careful postoperative follow-up is necessary in such cases and further improvements in the quality of glue or alternative methods will be necessary to prevent problems in the first place.

Thin basement membrane disease (以下TBMD) と診断した13症例を臨床病理学的に検討した。組織の検討は，従来の光学顕微鏡，電子顕微鏡，蛍光抗体法所見に加えて，酵素抗体法でIV型コラーゲンα鎖蛋白の発現も検討した。平均観察期間の6.1年で腎機能の低下を認めた症例はなかったが，酵素抗体法で糸球体係蹄壁にIV型コラーゲンα3・4・5鎖蛋白の発現の減弱がみられた男性の1症例では，蛋白尿の増加が見られた。このことからTBMDの診断・経過は慎重に対応する必要があり，IV型コラーゲンα鎖蛋白の検索を行うことはTBMDの診断およびAlport症候群との鑑別に有用と考えられた。