Myocardial infarction (MI) induces early-stage breast cancer progression and increases breast cancer patients’ mortality and morbidity. Insulin-like peptide 6 (INSL6) overexpression can impede cardiotoxin-induced injury through myofiber regeneration, playing a significant role in MI progression. To investigate the diverse significance of INSL6 in a variety of malignant tumors, we explored INSL6 through MI GEO dataset and multiple omics data integrative analysis, such as gene expression level, enriched pathway analysis, protein-protein interaction (PPI) analysis, and immune subtypes as well as diagnostic value and prognostic value in pancancer. INSL6 expression was downregulated in the MI group, and overall survival analysis demonstrated that INSL6 could be the prognostic biomarkers in the overall survival of breast cancer (BRCA). INSL6 expression differs significantly not only in most cancers but also in different molecular and immune subtypes of cancers. INSL6 might be a potential diagnostic and prognostic biomarker of cancers due to the high accuracy in diagnostic and prognostic value. Furthermore, we focused on BRCA and further investigated INSL6 from the perspective of the correlations with clinical characteristics, prognosis in different clinical subgroups, coexpression genes, and differentially expressed genes (DEGs) and PPI analysis. Overall survival and disease-specific survival analysis of subgroups in BRCA demonstrated that lower INSL6 expression had a worse prognosis. Therefore, INSL6 aberrant expression is associated with the progression and immune cell infiltration of the tumor, especially in KIRP and BRCA. Therefore, INSL6 may serve as a potential prognostic biomarker and the crosstalk between MI and tumor progression.

报道2例右上腔静脉缺如伴永存左上腔静脉、房间隔缺损的病例。病例1术中偶然诊断；据此经验，病例2术前应用对比增强计算机断层血管造影明确解剖诊断。2例体外循环分别采用了不同的静脉置管策略，病例2同时存在右心耳血栓形成，术中予以清除。

目的 探讨血管腔内分流栓在建立大鼠腹腔异位心脏移植模型中应用.方法 雄性SD大鼠40只,分为传统组和改进组,各20只,采用2％戊巴比妥钠麻醉.供体大鼠经口气管插管,正中开胸后机械通气.经右颈总动脉插入的20G钝针头推注4℃HTK液10 mL左右致使心脏停搏.获取供心后将其放入4℃HTK液保存.传统组仍采用经典大鼠腹腔异位心脏移植术进行手术.改进组采用如下方法:分别夹闭下腔静脉及腹主动脉,切开血管后置入分流栓并固定其两端.将供体的主肺动脉、升主动脉与受体的下腔静脉、腹主动脉做吻合.再次夹闭下腔静脉及腹主动脉,取出分流栓后排气收线打结,确认无出血后开放血管夹.结果 改进组手术成功10只,供心存活72 h以上,无下肢缺血及截瘫发生,未发现吻合口.传统组手术成功9只,1只死于术后吻合口出血.两组的总手术时间无明显差别.改进组在下肢肌肉组织病理表现、总缺血时间、CKM及LDH的含量等优于传统组.结论 在大鼠腹腔异位心脏移植术中,应用腔内分流栓可使血管阻断的时间缩短,吻合血管的难度下降,手术的成功率增加.