Objective To observe the microembolic signal(MES)and D-dimer level of atrial fi-brillation patients before and after warfarin anticoagulant therapy.Methods A total of 40 persistent atrial fibrillation patients with CHADS2 score≥1 were selected.Each of research object underwent MES monitoring and D-dimer level detection before and after warfarin anticoagulant therapy.We compared the results before and after the treatment.Results Before anticoagulant therapy,there were 1 2 cases with positive MES and 28 with negative MES;after the treatment,5 cases were posi-tive in MES and 35 were negative.The positive rate of MES significantly decreased after anticoagulant therapy(30.0% vs.12.5%,χ2 =3.66,P <0.05).The level of D-dimer was (273 ±81 )μg/L before anticoagulant therapy and (170 ±67)μg/L after the therapy.The level of plasmatic D-dimer significantly reduced after the treatment(t =10.09,P <0.05 ).Conclusion Both of MES and D-dimer level can be regarded as risk evaluation indicators of embolism in atrial fibrillation patients.

To observe the D-dimer levels and the numbers of micro-embolic signals (MES) in atrial fibrillation patients with different thromboembolic risk scores. A total of 216 persistent atrial patients were classified according to their different scores with a range of 0 -6.They were also divided into two groups by ≥2 or ＜ 2 according to the CardiacFailure,Hypertension,Age,Diabetes,Stroke 2 (CHADS2) point system.D-dimer levels and the numbers of MES were detected in all patients.A rising trend of D-dimer level and the number of MES was observed with the increases of CHADS2 score. D-dimer level and the number of MES in group 0 or 1 score were significantly lower than those in other high score groups (P ＜ 0.05).And the number of MES in group 5 or 6 score was significantly higher than those in other low score groups (P ＜ 0.05).D-dimer level and the number of MES in the group of ≥ 2 score were significantly higher than those in group ＜ 2 score ( P ＜ 0.01 ).It suggests that D-dimer level and the nunber of MES may reflect the thromboembolic risks in atrial fibrillation patients.

目的 探讨脑钠肽(BNP)水平和心力衰竭(HF)严重程度的关系及临床应用.方法 选择2008年4月～2010年3月住院治疗的心力衰竭患者120例,正常对照组30例,用ADVIA Centauf BNP测定法定量测定血浆脑钠肽水平.对各级心功能组和正常对照组的血浆脑钠肽水平进行比较.结果 HF组总体血浆BNP水平明显高于对照组(P<0.01),NYHA Ⅰ、Ⅱ、Ⅲ、Ⅳ级组间血浆BNP依次递增(P<0.01).结论 血浆BNP浓度与心功能分级呈正相关,血浆BNP的浓度变化对心力衰竭的诊断、严重程度的判断有重婴价值.