To explore the clinical effect of hydroxychloroquine sulfate, dexamethasone, and transfer factor (TF) for patients with oral lichen planus (OLP).Methods:A total of 180 patients with OLP treated in Mengyin County People's Hospital from January 2018 to January 2022 were selected for the random control trial. They were divided into an observation group and a control group by the random number table method, with 90 cases in each group. There were 41 males and 49 females in the observation group; they were (48.96±5.73) years old. There were 39 males and 51 females in the control group; they were (49.13±5.64) years old. The control group were treated with hydroxychloroquine sulfate and dexamethasone, and the observation group with hydroxychloroquine sulfate, dexamethasone, and TF. The curative effects, scores of Visual Analogue Scale (VAS), erosion areas, levels of nitrite ion (NO 2-), inflammatory factors [interleukin-10 (IL-10), interleukin-17 (IL-17), and interferon-γ (IFN-γ)], immune function (CD3+, CD4+, CD8+, and CD4+/CD8+), and adverse reactions were compared between the two groups. t and χ2 tests were applied. Results:The treatment efficacy of the observation group was higher than that of the control group [95.56% (86/90) vs. 85.56% (77/90); P<0.05]. After the treatment, the scores of VAS and Reticulation-Erosion-Ulcer Scale (REU) and the vesicular area in the observation group were lower than those in the control group [(0.64±0.15) vs. (1.21±0.23), (0.78±0.16) vs. (1.33±0.27), and (1.52±0.23) cm 2vs. (1.74±0.27) cm 2; all P<0.05]. After the treatment, the levels of NO 2-, IL-17, and IL-10 in the observation group were lower than those in the control group [(10.31±1.65) μmol/L vs. (13.89±1.44) μmol/L, (0.18±0.06) ng/L vs. (0.31±0.09) ng/L, and (8.67±1.83) pg/L vs. (12.01±1.64) pg/L; all P<0.05]; the IFN-γ level in the observation group was higher than that in the control group [(12.03±2.62) pg/L vs. (8.52±2.12) μmol/L; P<0.05]. After the treatment, the CD3 +, CD4 +, and CD4 +/CD8 + in the observation group were higher than those in the control group [(56.16±5.71)% vs. (51.73±5.20)%, (38.56±3.97)% vs. (36.21±3.74)%, and (1.46±0.27) vs. (1.32±0.25); all P<0.05]; the CD8 + in the observation group was lower than that in the control group [(26.26±3.20)% vs. (27.68±3.39)%; P<0.05]. There were no statistical difference in the incidence of adverse reactions between the two groups ( P>0.05). Conclusion:The clinical curative effect of hydroxychloroquine sulfate, dexamethasone, and TF for patients with OLP is good and can effectively adjust the level of NO 2- in saliva, improve their immune function and inflammatory response, and relieve their pain.

目的:分析与探讨联用β-内酰胺类抗菌药物和阿奇霉素的可行性与合理性。方法:回顾性分析2020年12月-2022年1月在本院接受治疗的120例细菌性肺炎患儿，通过平均分配方式划分患者为研究组和对照组，并对所有患儿实施针对性治疗，对比各组治疗效果。结果:衣原体和支原体感染情况下，阿奇霉素的效果比β-内酰胺类抗菌药物的效果好，阿奇霉素治疗期间的不良反应相对比较大。对两组患儿行相应治疗后，观察组患儿全部治疗有效率，而对照组患儿则仅为85.0%，观察组患儿治疗效果显著优于对照组，P<0.05，存在统计价值。结论:小

目的:探究精细化药房管理模式应用下对提高医院药房药品调配的影响.方法:选择2021年1月至2021年12月本院药房发放药品处方中的2000份作为研究对象,依照处方发放时间进行分组,以2021年1月至6月的1000份为一组(未实施精细化管理),以2021年7月至12月1000份为另一组(实施精细化管理).比较管理实施前后药房内平均候药的时间、处方平均调配的时间以及管理质量(处方书写不规范、药品调配不准确、药品发放不准确、不合格).结果:精细化管理实施后药房平均候药时间、处方平均调配时间均短于实施前药房平均候