This study was aimed to investigate the application of micro ribonucleic acid (miRNA) combined with nanographene particles in molecular diagnosis of depression. After the sheet-shaped graphene oxide was mixed with a solvent to form a solution, it was atomized at high temperature to form droplets and extract nanographene oxide, which was applied to an electrochemical sensor. 90 patients with depression were selected as the research objects and they were randomly divided into control group and experimental group, patients from the two groups received the miRNA molecular diagnosis and the miRNA molecular diagnosis combined with nanographene electrochemical sensor dopamine detection method, respectively. As a result, the diagnostic sensitivity (82.4%), specificity (90.3%), and accurate index (71.3%) of patients from the experimental group were higher obviously than those of the control group (54.3%, 72.8%, and 55.6%) ( P <0.05). The expression levels of MiR-92b-5p and MiR-19a-3p in patients with depression were higher markedly than the levels of the normal population ( P <0.05). The detection rates of mild depression, moderate depression, and severe depression in patients from the experimental group were 97.3%, 96.5%, and 91.2%, which were higher greatly than the rates of the control group (84.3%, 85.4%, and 83.2%) ( P <0.05). Besides, the false positive rate (11.2%) and false negative rate (5.6%) of patients from the experimental group were sharply lower than the rates of the control group (31.5% and 16.4%) ( P <0.05). In short, miRNA combined with nanographene electrochemical sensors could accurately diagnose depression with high accuracy and sensitivity, which could be applied in the clinical diagnosis.

Objective Our objective was to assess the incidence and quality of reporting of published health economic evaluations in mainland China and compare the quality of peer-reviewed articles in Chinese and English. Methods A comprehensive search was conducted for economic evaluations pertaining to China published from 2006 to 2015 using the PubMed, CBM, CMCC, CNKI, VIP, and Wanfang databases. All studies in English that met the inclusion criteria were included. For studies in Chinese, 200 sampled studies were included according to the random seeds method, and the same number of the most-cited studies in Chinese as those in English were included according to the number of citations and journal grades. Researchers independently assessed the quality of the studies using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results After literature search and screening, a total of 310 studies were identified. The majority of these studies were cost-effectiveness studies (82.26%). Scores among different CHEERS items varied greatly. There was a gap between the average quality scores of the studies published in Chinese and those published in English (49.78 ± 9.31 vs. 82.48 ± 17.69) and between the average quality scores of the included most-cited studies in Chinese and English, which was slightly smaller (54.08 ± 10.27 vs. 82.48 ± 17.69). The methods, results, and discussion sections of studies published in Chinese were of low quality. Conclusion The quality of reporting of health economic evaluations in mainland China has developed slowly. Most of the included studies were incomplete in the presentation of content, making the results less reliable. It is important to standardize and improve the quality of Chinese health economic research.

目的:探索全球金融危机背景下妇幼健康指标的短期与长期变化趋势,为进一步提升妇幼健康水平提供参考.方法:基于1991-2018年宏观时间序列数据,在考虑宏观经济指标的前提下,采用自回归分布滞后模型(ARDL)与误差修正模型(ECM)进行分析.结果:长期来看,金融危机虚拟变量仅对5岁以下儿童死亡率具有显著影响,回归系数为-7.332.短期来看,新生儿死亡率在全球金融危机当期及滞后一、二期的回归系数皆为负值,但5岁以下儿童死亡率、婴儿死亡率及孕产妇死亡率的回归系数会在滞后一期或滞后二期时由正转负.结论:全球金融危机背景下,妇幼健康水平既有积极变化又有消极变化,且在短期内经历了一个从恶化到改善的过程,国内经济回暖及新医改的开展都可能是导致出现这种变化的原因.

Our objective was to assess the incidence and quality of reporting of published health economic evaluations in mainland China and compare the quality of peer-reviewed articles in Chinese and English.A comprehensive search was conducted for economic evaluations pertaining to China published from 2006 to 2015 using the PubMed, CBM, CMCC, CNKI, VIP, and Wanfang databases. All studies in English that met the inclusion criteria were included. For studies in Chinese, 200 sampled studies were included according to the random seeds method, and the same number of the most-cited studies in Chinese as those in English were included according to the number of citations and journal grades. Researchers independently assessed the quality of the studies using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist.After literature search and screening, a total of 310 studies were identified. The majority of these studies were cost-effectiveness studies (82.26%). Scores among different CHEERS items varied greatly. There was a gap between the average quality scores of the studies published in Chinese and those published in English (49.78 ± 9.31 vs. 82.48 ± 17.69) and between the average quality scores of the included most-cited studies in Chinese and English, which was slightly smaller (54.08 ± 10.27 vs. 82.48 ± 17.69). The methods, results, and discussion sections of studies published in Chinese were of low quality.The quality of reporting of health economic evaluations in mainland China has developed slowly. Most of the included studies were incomplete in the presentation of content, making the results less reliable. It is important to standardize and improve the quality of Chinese health economic research.

运用新制度经济学理论一方面从纵向历史发展维度对我国医院评审评价制度发展过程进行制度变迁和制度均衡分析,另一方面从横向国际比较维度梳理和归纳国际组织和典型国家医院评审评价制度发展经验,最终提出促进我国医院评审评价系统性制度创新的政策建议:首先政府部门应尽快出台新的医院评审标准,并引导建立具有区分度的医院评价标准;其次推动我国医院评审制度通过国际医疗质量协会外部评估协会认证;最后尽快成立中国医疗机构评审组织认证与监督委员会对国内第三方机构进行认证和许可.