Acute-on-chronic liver failure (ACLF) is a syndrome characterized by multiple organ failure and high short-term mortality rate, and it has always been a research hotspot in the field of severe liver diseases. Therefore, early and accurate risk stratification and timely intervention are of great significance to improve prognosis. This article summarizes the serum biomarkers identified in recent years for evaluating the prognosis of patients with ACLF, and it is pointed out that new serum biomarkers have an important guiding significance in the prognostic evaluation of ACLF patients.

[据Journal of Hepatology 2020年9月报道]题:慢性高氨血症可诱导外周炎症,导致小鼠认知障碍:抗TNFα治疗可逆转(作者Balzano T等) 慢性高氨血症可诱导神经炎症,引起认知障碍.但是高氨血症如何引起神经炎症尚不清楚.研究旨在评估:慢性高氨血症是否会诱发周围炎症,再进一步导致神经炎症、神经传导改变和空间学习受损;以及当高氨血症消除或用抗TNFα治疗周围炎症后,神经炎症和损伤是否是可逆的.