The purpose of this study is to clarify the relationships of anxiety, stress and the family support to self-esteem in patients with ischemic heart disease, who received coronary artery intervention. 143 patients were enrolled to this study. The questionnaire survey included such scales as, selfesteem; Rosenberg Self-Esteem Scale, anxiety; Hospital Anxiety and Depression Scale, stress; Daily Irritation Scale, and family background; Family Support Scale and Family Environment Scale. The following were mutually related: anxiety, stress and the family support. Self-esteem was related to anxiety, stress, and the family support. Significant variables in the regression equation were family support, anxiety, age, arrhythmia, and restenosis. Results indicated that the level of self-esteem showed negative association with fear family support, strong anxiety, elder, and arrhythmia. The results suggest the need to instruct patients with ischemic heart diseases and their family members on how to cope with their anxiety or stress effectively.