Adolescents with chronic catarrhal gingivitis aged from 14 to 17 years without general somatic pathology affecting the etiopathogenesis of inflammatory periodontal diseases were observed. Of the total number of patients examined, 19 were at the stage of ortho-dontic treatment. The control group consisted of 40 clinically healthy patients. The state of the local immune status of the oral cavity was assessed by the functional activity of phagocytes, the content of mixed saliva IgA, IgM, IgG, sIgA, IL-4, IL-8 by solid-phase enzyme immunoassay. In adolescents with chronic gingivitis, there are clearly pronounced shifts in local immunity, which are represented by an increase in the of IgG, sIgA, IL-4, IL-8, the functional reserve of neutrophils, index stimulation of neutrophils compared to the control group, as well as a decrease in the level of IgM and the concentration of oxygen-dependent enzymes in the cytoplasm of phagocytes in the nbt-spontaneous test.

The aim of the study was to assess the level of cytokines and components of the complement system in blood plasma and in gingival pocket wipe-sample in teenagers with chronic generalized catarrhal gingivitis against the background of the use of Parodontocide gel. 42 teenagers aged from 14 to 17 years with chronic generalized catarrhal gingivitis were under constant observation. They were divided into 2 groups: patients of the 1st group received basic treatment, and patients of the 2 groups additionally received Parodontocide gel as a part of the basic therapy. Before therapy and after 2 weeks, the levels of tumor necrosis factor alpha (TNFα), IL-2, IL-1α, IL-6, IL-8, interferon α (IFα), IL-18, IL-4, and IL-10, interleukin-1 receptor antagonist (IL-1Ra), C 3 -, C 3 - C 4 -, C 5 -, C 5a -components of complement, H factor, C 1 -inhibitor and sIgA were determined. The use of basic therapy only in teenagers with chronic generalized catarrhal gingivitis does not have an adequate immunocorrective effect on the cytokine level and the complement system, but requires the use of additional pharmacological correction, the gel-like drug «Parodontocid» is effective in this regard.