2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5yl methacrylates were synthesized for the first time by reaction of 5-hydroxyuracil derivatives with methacrylic anhydride. 5-Hydroxyuracil derivatives are involved in this reaction in the dioxo form.
6-Methyluracil sodium salt reacts with 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracils in DMF, yielding products of alkylation at the nitrogen atom in position 3 of the uracil ring.
Reactions of 1,3-bis(3-chloro-2-hydroxypropyl)uracil, 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracil, 1,3-bis(3-chloro-2-hydroxypropyl)-5-hydroxy-6-methyluracil, and 1,3-bis(3-chloro-2-hydroxypropyl)-5-fluorouracil with 2-amino-4-methylthiobutanoic acid (methionine) were studied for the first time.
The extraction properties of N,N'-dipentylethylenediamine-N'-thiocarbaldehyde (S) with respect to palladium(II) and silver(I) in nitric solutions have been studied using chloroform and toluene as diluents. Optimal conditions for the extraction of palladium(II) and its separation from silver(I) have been found. It has been shown that the extraction of metal ions follows the solvation mechanism. Apparent concentration constants and thermodynamic parameters of palladium(II) extraction were determined.
A reaction was studied of previously unknown 1,3-bis(2-hydroxy-3-chloropropyl)uracil, 1,3-bis(2-hydroxy-3-chloropropyl)-6-methyluracil, and 1,3-bis(2-hydroxy-3-chloropropyl)-5-fluorouracil with 1,3-bis[3-(3-methyl-2H-5-pyrazolon-1-yl)-2-hydroxypropyl]-6-methyluracil.
ChemInformVolume 33, Issue 39 p. 213-213 Natural Products Synthesis and Pharmacological Activity of Novel Acyclonucleoside Derivatives (III), (IV). V. P. Krivonogov, V. P. Krivonogov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. G. Kozlova, G. G. Kozlova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Sivkova, G. A. Sivkova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorI. R. Kil'metova, I. R. Kil'metova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorA. E. Belov, A. E. Belov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorI. B. Abdrakhmanov, I. B. Abdrakhmanov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorA. F. Ismagilova, A. F. Ismagilova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. V. Spirikhin, L. V. Spirikhin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorI. Yu. Kochurova, I. Yu. Kochurova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author V. P. Krivonogov, V. P. Krivonogov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. G. Kozlova, G. G. Kozlova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorG. A. Sivkova, G. A. Sivkova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorI. R. Kil'metova, I. R. Kil'metova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorA. E. Belov, A. E. Belov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorI. B. Abdrakhmanov, I. B. Abdrakhmanov Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorA. F. Ismagilova, A. F. Ismagilova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorL. V. Spirikhin, L. V. Spirikhin Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this authorI. Yu. Kochurova, I. Yu. Kochurova Inst. org. khim. Ural. otd. Ross. Akad. nauk, Ufa 450054, RussiaSearch for more papers by this author First published: 19 May 2010 https://doi.org/10.1002/chin.200239213Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume33, Issue39October 1, 2002Pages 213-213 RelatedInformation
A procedure was developed for synthesizing nitrogen-and-sulfur-containing pyrimidine derivatives by reactions of 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracil with 1-butanethiol and chloroacetyl chloride, followed by treatment of the resulting 1,3-bis[3-chloro-2-(chloroacetoxy)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione with 1-butanethiol, morpholine, and piperidine. Oxidation of the sulfur-containing products with NaIO4 gave the corresponding sulfoxides.
A reaction was studied of newly synthesized 1,3-bis(2-hydroxy-3-chloropropyl)uracil and 1,3-bis(2-hydroxy-3-chloropropyl)-6-methyluracil with hydrazine hydrate followed by treating the compounds formed with ethyl acetoacetate. The hydrazones obtained cyclized into pyrazolones in the presence of sodium methylate.