Terahertz (THz) radiation and related technologies are rapidly developed and find their application in different branches of science and technology, including medical diagnostics and therapy. This poses a problem of determining the safety limits of the human body exposure to THz radiation, which is closely related to a problem of biological activity of THz waves. Therefore, in this work, the current state of research in the area of THz radiation – cells interaction is overviewed.

A large class of arthropod transcription factors is formed by proteins with a characteristic N-terminal Zinc-finger-Associated Domain (ZAD) which contains four cysteine residues that coordinate a zinc ion. The number of putative proteins with ZAD in the Drosophila genome exceeds 90, and the degree of sequence similarity between these domains can be as low as 23%. Efficient binding of ZADs from the proteins Grau, ZIPIC, and Zw5 to the translation elongation factor EF1α1 in nuclear and cytoplasmic extracts has been demonstrated. EF1α1 is probably involved in the regulation of the activity of ZAD-containing transcription factors.

В обзоре рассмотрены основные биологические процессы в организме дрозофилы, которые находятся под контролем сигнального пути Jak/Stat. Плодовая мушка представляет собой удобный объект для изучения роли этого сигнального пути в различных аспектах онтогенеза.

JAK/STAT is one of the conservative signaling pathways in higher eukaryotes which plays a critical role in different ontogenesis processes. This article gives a review of the pathway structure at the molecular level, mainly in a model organism Drosophila. There are data about relationship of the signaling pathway and transcription machinery of higher eukaryotes.

JAK/STAT signaling pathway plays a critical role in different ontogenesis processes of higher eukaryotes. Fruit fly drosophila is a handy model system used to study this pathway since major components of the pathway are represented by unique factors. This article describes the usage of Drosophila melanogaster S2 cells in studies of the pathway's target genes activation. We showed that S2 cells contain plenty of STAT protein which migrates into nucleus under cells treatment with pervanadate. Then we demonstrated that under pervanadate action STAT protein along with other transcription factors is recruited onto regulatory sequences of target genes and activates their transcription.

The ENY2/Sus1 is a multifunctional transcription factor which couples transcription with mRNA export. It is the component of the SAGA/TFTC and TREX-2/AMEX protein complexes. Recently, we described the interaction of ENY2 with one more protein complex, THO. Moreover, our data indicate that ENY2 associates with other nuclear and cytoplasmic factors. Thus, being the component of a number of protein complexes, ENY2 plays the role of an adaptor molecule, involved into the integration of different cellular processes, specifically, subsequent stages of gene expression.