To compare the sleep characteristics and cognition between rapid eye movement sleep behavior disorder (RBD) patients and non‐RBD (nRBD) healthy control subjects and to determine the correlation between sleep and cognition in RBD patients.

Objective To evaluate the neuropsychological performance of RBD patients and its correlations with ob-jective sleep parameters. Methods Twenty-two RBD patients diagnosed by video-polysomnography( v-PSG) in neurology clinic of TianJin Medical University General Hospital and Twenty-three healthy gender,age and education-level matched subjects were enrolled. Subjects underwent neuropsychological tests,including mini-mental state examination(MMSE),Au-ditory verbal learning test(AVLT),Rey Complex Figure Test(RCFT),Clock Drawing Test(CDT),Symbol digit modalities test(SDMT),Trail Making Test A and B(TMT A and TMT B),Stroop test A,B and C,Animal fluency test(AFT),City flu-ency test(CFT),Animal-City fluency test,Boston naming test(BNT). Neuropsychological performance and objective sleep parameters were compared between the two groups,correlations between neuropsychological performance and objective sleep parameters in RBD group were analysed. Results Compared with the control group, RBD patients performed worse in MMSE,immediate memory,short and long delay recall of AVLT,time of RCFT,TMT A,TMT B,Stroop A,Stroop B,Stroop C with significant difference(P<0. 05);the mean percentage of NREM-I sleep increased,NREN-II and NREM-III sleep decreased,periodic leg movement index increased in RBD patients. Furthermore,lower sleep efficiency was correlated with decreased SDMT score(r=0. 491,P=0. 020),CFT score(r=0. 436,P=0. 043) and more time of TMT A(r= -0. 654,P=0. 001),lower total sleep time was correlated with less RCFT and BNT score(r=0. 600,P=0. 003;r =0. 482,P =0. 023),more time of TMT A(r= -0. 573,P=0. 005) in RBD patients. Conclusions RBD patients exhibited declined cognition,impaired multi-domain neuropsychological performance including vebral learning memory,exeuctive and visuospa-tial ability,disturbed objective sleep architecture,increased periodic leg movement index. Decreased total sleep time and sleep efficiency may contribute to neuropsychological performance deterioration in RBD patients.

Objective To evaluate the sleep structure of rapid eye movement sleep disorder (RBD) patients and its correlations with emotional state,autonomic nerve system function symptoms,and sleep quality.Methods Twenty-two RBD patients examined in our hospital from October 2014 to May 2016 who complained of behavior disorders and conformed diagnosis by video-polysomnography (v-PSG) were chosen as RBD group;23 healthy gender,age and education-level matched subjects confirmed without RBD by v-PSG were selected as control group.Their emotional state,autonomic nerve function and sleep quality were assessed by center for epidemiological survey depression scale (CES-D),apathy evaluation scale (AES),scale for outcomes in PD for autonomic symptoms (SCOPA-AUT),and scale for outcomes in PD for sleep (SCOPA-SLEEP).The differences in sleep structures,periodic leg movement index (PLMI),apnea hypopnea index (AHI) and arousal index between RBD group and control group were compared.The differences of scores of emotional state,autonomic nerve system function symptoms were compared between the two groups.The correlations of sleep structure with emotional state,autonomic nerve system function symptom,and sleep quality in RBD group were analyzed.Results As compared with those of the control group,the proportion of non-rapid eye movement (NREM)-Ⅰ sleep of RBD group was significantly increased,proportions of NREM-Ⅱ sleep and NREM-Ⅲ sleep were statistically reduced,PLMI,CES-D scores,urinary and digestive system questionnaire and overall scores in the RBD group were significantly increased (P＜0.05).In patients from RBD group,CES-D scores were positively correlated with proportion of NREM-I sleep (r=0.520,P=0.000);nighttime sleepiness questionnaire and overall scores were positively correlated with PLMI (r=0.465,P=0.029;r=0.444,P=0.039);daytime sleepiness scores were negatively correlated with proportion of NREM-Ⅲ sleep (r=-0.480,P=0.041);cardiovascular system symptom was correlated with PLMI (r=0.439,P=0.041).Conclusion RBD patients suffer sleep structure disturbance,depression tendency,digestive and urinary system of autonomic nerve symptoms;sleep quality scores and total scores,cardiovascular system symptoms scores are positively correlated with LMI;daytime sleepiness is negatively correlated with reducing phase Ⅲ sleep,CES-D scores are correlated with increasing NREM-I sleep and unbalanced neurotransmitter,especially,5-TH level.