A case diagnosed as diffuse giant cell tumor of tendon sheath with chondroid metaplasia in right temporoman-dibular joint was reported. The clinicopathological features, diagnosis, and treatment were discussed with the literature review.

数字化切片库的建立打破了传统组织切片的局限,将其引入传统的口腔组织病理教学中,应用于从本科教育、住院医师规范化培训到网络教育、继续教育等各个层次的教学,可以充分发挥学生在教学中的主体作用,激发学生的学习热情,提高学生自主学习和创新能力.

Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare subtype of odontogenic sarcoma, with no more than 19 cases reported in the English literature to date. AFOS is a biphasic neoplasm, with deposits of dentin and enamel matrix. We herein present a case of AFOS with active epithelial proliferation in a 31-year-old female patient. The patient was referred to the West China Hospital of Stomatology (Chengdu, China) due to a 6-month history of a swelling in the left mandible. Following clinical and radiological examination, the initial preoperative diagnosis was ameloblastoma, with local invasion and the possibility of malignant transformation. Left hemimandibular resection was subsequently performed. The postoperative histopathological diagnosis was AFOS, accompanied by active epithelial proliferation. Immunohistochemically, cytokeratin (CK)14 and CK19 were intensely positive in the epithelium, whereas the mesenchymal cells were strongly positive for vimentin. The Ki-67 labeling index was considerably higher in the mesenchymal component (mean, 40%) compared with that in the epithelial element (mean, 5-8%). Three months after the surgical procedure, the patient remained clinically and radiologically disease-free.

口腔生物学是口腔医学专业课和口腔临床知识相连接的重要学科，是从基础医学理论上理解各种口腔疾病的发生、发展和预后的一门学科。《口腔生物学》的开设可以让大学本科生掌握口腔基础学科的理论知识，并且提高他们进行科研活动的兴趣，本文从《口腔生物学》开设的必要性、教材分析、教学方法等多方面阐述，探讨如何提高大学本科阶段口腔生物学的教学质量。