ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES Human Immunoglobulin heavy chains locus Immunoglobulin heavy chain genes of mouse Immunoglobulin ? genes of human and mouse Immunoglobulin lambdav (IGL) genes of human and mouse The Mechanism of V(D) J Recombination Transcription of Immunoglobulin genes B CELLS AND THEIR DEVELOPMENT Early B cell development to a mature , antigen-sensitive cell - cellular stages and molecular decisions Allelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J Recombination The Development of Human B Lymphocytes Development and function of B cell subsets B CELL DIFFERENTIATION INDUCED BY Ag STIMULATION Structure and function of B cells antigen receptor complexes Regulation of antigen receptor signaling by the co-receptors, CD19 and CD22 The dynamic structure of antibody responses Dynamics of B cell migration to and within secondary lymphoid organs Characteristics of mucosal B cells with emphasis on the human secretory immune system The Cellular Basis of B Cell Memory Immunoglobulin assembly and secretion Fc And Complement Receptors Ig GENE ALTERATION IN PERIPHERY Regulation of Class Switch Recombination Molecular Mechanism of Class Switch Recombination Molecular Mechanism of Hypermutation Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody DISEASES OF B CELLS Chromosomal Translocations in B-cell Leukemias and Lymphomas Classification and Characteristics of Mouse B Cell-Lineage Lymphomas B cells producing pathogenic autoantibodies Immunodeficiencies Caused by B Cell Defects EVOLUTION OF Ig GENES Diverse forms of Immunoglobulin Genes in Lower Vertebrates Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT The zebrafish immune system The Origin of V(D)J Diversification FUNCTION AND APPLICATION OF IMMUNOGLOBULINS Antibody Structure and Recognition of Antigen Monoclonal antibodies from display libraries Humanization of Monoclonal Antibodies Human monoclonal antibodies from translocus mice

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. This book contains articles that address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.