Objective To investigate the medication regularity of phlegm and blood atasis in the treatment of carotid atherosclerotic(CAS)based on the platform of traditional Chinese medicine inheritance.Methods The database of CNKI,VIP,Wanfang Data,Chinese Biomedical Database,PubMed and Cochrane library were retrieved to search for randomized controlled trial on the phlegm and blood atasis in the treatment of CAS.The search time was from the establishment of the database to July 2023.The traditional Chinese medicine inheritance platform(V2.5)was used for descriptive statistics and association rules analysis,and network visualization of core traditional Chinese medicine.Results A total of 62 articles were included,and a total of 62 prescriptions were obtained.There were 137 flavors of traditional Chinese medicine involved,and the total frequency of use was 662 times,of which 7 flavors of traditional Chinese medicine with frequency of≥20 times were followed by salvia miltiorrhiza,rhizome of Chuanxiong,astragalus membranaceus,leech,Poria cocos,hawthorn and rhizoma alismatis.The four Qi of 137 flavors of traditional Chinese medicine was mainly warm and cold,and the five flavors of them were mainly bitter and sweet;and they were mainly attributed to the liver meridian and spleen meridian.Set the support level to 12,the confidence level to 0.600,and the Chinese medicine combination frequency was sorted according to the frequency of use,and 19 traditional Chinese drugs combinations with using frequency of≥10 times and 12 association rules of traditional Chinese drugs were obtained.The results of network visualization of core traditional Chinese medicine analysis showed that there were 12 core traditional Chinese drugs.Conclusion The traditional Chinese medicine of phlegm and blood atasis in the treatment of CAS mainly includes salvia miltiorrhiza,rhizome of Chuanxiong,astragalus membranaceus,leech,Poria cocos,hawthorn and rhizoma alismatis.The four Qi of them are mainly warm and cold,the five flavors of them are mainly bitter and sweet,and they are mainly attributed to the liver meridian and spleen meridian.
目的 分析黄永生教授治疗室性期前收缩的用药规律.方法 收集2012-2021年黄永生教授于长春中医药大学附属医院国医堂门诊诊治的室性期前收缩患者232例,涉及232首中药处方,157味中药.采用中医传承辅助平台(V2.5),统计中药使用频次,分析中药组合、中药关联规则及核心中药,基于复杂系统熵聚类分析提取新方组合.结果 157味中药中使用频次≥30次的中药40味,使用频次≥100次的中药9味,依次为蝉蜕、僵蚕、紫石英、酸枣仁、磁石、合欢、九节菖蒲、百合、白附子.以中药组合使用频次进行降序排列,共得到17个使用频次≥80次的中药组合,24条中药关联规则,9味核心中药,分别为蝉蜕、紫石英、僵蚕、合欢、九节菖蒲、酸枣仁、百合、白附子、磁石.基于复杂系统熵聚类分析,共得到治疗室性期前收缩的新方组合2首,分别为"降香-水蛭-丹参-檀香""紫石英-淫羊藿-制附子-巴戟天-龙齿".结论 黄永生教授是在蝉蜕、僵蚕、紫石英、酸枣仁、磁石、合欢、九节菖蒲、百合、白附子9味中药的基础上加减化裁治疗室性期前收缩,以达到调整阴阳治其本、缓急止悸治其标的治疗目的;此外,本研究还提取出2个新方组合,为室性期前收缩的临床遣方用药提供了新的思路.