The invention provides a calculating method and device for the electroacupuncture starting time. The calculating method comprises the steps that scanning pulse sequence control information of magneticresonance imaging equipment and electroacupuncture parameter information of an electroacupuncture stimulating device are obtained; the pulse starting time of the magnetic resonance imaging equipmentand the empty scanning time before formal scanning are determined based on the scanning pulse sequence control information; the delayed scanning time of a scanning acupuncture reaction of the magneticresonance imaging equipment after the electroacupuncture stimulating device conducts acupuncture is determined from the electroacupuncture parameter information; and the starting time of the electroacupuncture stimulating device is determined based on the pulse starting time, the empty scanning time and the delayed scanning time. In this way, the time interval between the magnetic resonance imaging equipment and the electroacupuncture stimulating device can be accurately controlled, the derivation between the influences of scanning imaging and real acupuncture stimulating on brain function activities is lowered advantageously, and the accuracy rate of scanning imaging is increased.

Background: Acupuncture, based on theory of meridians and acupoints, is a key component of traditional Chinese medicine that has been practiced for more than three thousand years. Stroke and knee pain are two diseases and conditions for which acupuncture has been proved effective in World Health Organization (WHO) official report published in 2003. Methods: Taking stroke and knee osteoarthritis (KOA) as two examples, systematic review and Cochrane review in Pub Med were searched with keywords as “acupuncture & stroke” and “acupuncture & knee osteoarthritis” from Jan. 1st, 2016 to present. Four reviews related to stroke and 5 reviews about knee osteoarthritis were included. Other literatures associated with mechanism or clinical practices were also cited. WANG Xiangbin1,2,3*, TAO Jing1,2,3, WANG Xiaoling1,2,3, XIE Xuerong4, HE Jian1,2,3, CHEN Jian5, HOU Meijin1,2,3, YU Jiao1,2,3, XIONG Feng1,2,3 and CHEN Bo1,2,3 1College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, China 2Fujian Key Laboratory of Rehabilitation Technology, China 3Fujian provincial rehabilitation industrial institution, Fuzhou, China 4Rehabilitation Department of the 3rd People’s Hospital affiliated to Fujian University of Traditional Chinese Medicine, China 5Hospital of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, China *Corresponding author: WANG Xiangbin, College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine; Fujian Province 350122, China, Tel: 0086-0591-22861815, Email: wangxbin@hotmail.com Published Date: September 20, 2017

BACKGROUND:Depression is the most common form of mental disorder in community and health care settings and current treatments are far from satisfactory. Vagus nerve stimulation (VNS) is a Food and Drug Administration approved somatic treatment for treatment-resistant depression. However, the involvement of surgery has limited VNS only to patients who have failed to respond to multiple treatment options. Transcutaneous VNS (tVNS) is a relatively new, noninvasive VNS method based on the rationale that there is afferent/efferent vagus nerve distribution on the surface of the ear. The safe and low-cost characteristics of tVNS have the potential to significantly expand the clinical application of VNS.METHODS:In this study, we investigated how tVNS can modulate the default mode network (DMN) functional connectivity (FC) in mild or moderate major depressive disorder (MDD) patients. Forty-nine MDD patients were recruited and received tVNS or sham tVNS (stVNS) treatments.RESULTS:Thirty-four patients completed the study and were included in data analysis. After 1 month of tVNS treatment, the 24-item Hamilton Depression Rating Scale score reduced significantly in the tVNS group as compared with the stVNS group. The FC between the DMN and anterior insula and parahippocampus decreased; the FC between the DMN and precuneus and orbital prefrontal cortex increased compared with stVNS. All these FC increases are also associated with 24-item Hamilton Depression Rating Scale reduction.CONCLUSIONS:tVNS can significantly modulate the DMN FC of MDD patients; our results provide insights to elucidate the brain mechanism of tVNS treatment for MDD patients.

Objective:To observe the nerve cell metabolism of hippocampus in focal cerebral ischemia/reperfusion (FCIR) rats, and explore the mechanism of electroacupuncture (EA) improving the learning and memory ability of FCIR rats.Methods:Sprague-dawley (SD) rats were randomly divided into sham operated group, model group and EA group. Cerebral ischemia model of middle cerebral artery occlusion (MCAO) was established in rats by using Koizumi suture method. The rats in the EA group were administered EA at Baihui (DU20) and Shenting (DU24) for seven days, one time daily and 30 minutes each time. The learning and memory ability of rats was evaluated by Morris water maze, the cerebral infarct volume was assessed by the small animal MRI T2-weighted image, the nerve cell metabolism of hippocampus was observed by magnetic resonance spectroscopy (MRS). Morris water maze was used to evaluate learning and memory ability, T2-weighted imaging was used to assess the cerebral infarct volume, and magnetic resonance spectroscopy (MRS) was used to observe the nerve cell metabolism of hippocampus.Results:After seven days of EA treatment, the numbers of crossing platform of FCIR rats were significantly increased in Morris water maze (P<0.01). The cerebral infarct volume of FCIR rats was decreased (P<0.01). The ratio of left content to right content of N-Acetylaspartate (NAA) and Choline-containing compounds (Cho) was improved respectively, and the change of Glutamate (Glu) was not significant (P>0.05).Conclusion:EA at DU20 and DU24 acupoints can improve the ability of learning and memory after FCIR by enhancing NAA and Cho metabolism of hippocampus and protecting neurons in rats.

Alisol A 24-acetate, a triterpenoid extracted from Alisma orientale, has shown antiatherosclerotic actions. The purpose of this study was to evaluate the inhibition of alisol A 24-acetate on oxidized low-density lipoprotein (Ox-LDL)-induced phenotypic transformation and migration of rat vascular smooth muscle cells (VSMCs), and to explore the underlying mechanisms. VSMCs were pretreated with alisol A 24-acetate and a specific extracellular signal-regulated kinase (ERK) inhibitor, U0126, and then stimulated with 50 mg/l Ox-LDL in vitro. The expression of VSMC phenotypic marker SM22α was determined using immunocytochemistry, and the migration of VSMCs was detected using a scratch-wound healing assay. The expression of matrix metalloproteinase (MMP)-9, MMP-2, phosphorylated ERK1/2 (pERK1/2) and total ERK was determined. Ox-LDL treatment caused a reduction in SM22α expression, VSMC transformation to the synthetic phenotype, increased MMP-2 and MMP-9 synthesis, the extension of VSMC migration distance and the upregulation of pERK1/2 expression, while the addition of alisol A 24-acetate or U0126 resulted in the elevation of SM22α expression, VSMC transformation to the contractile phenotype, a reduction in MMP-2 and MMP-9 expression, the shortening of cell migration distance and decreased pERK1/2 expression. The results of this study demonstrate that alisol A 24-acetate effectively reverses the phenotypic transformation and inhibits the migration of VSMCs, which may be associated with the suppression of the ERK1/2 signaling pathway.

To search in the database of "Pubmed" and "CNKI" for the Chinese and English literatures related to Rehabilitation Outcome Measures in recent 10 years and to expound Rehabilitation Outcome Measures, it is a new rehabilitation medicine concept and the representativeness meaning of rehabilitation medicine environment, as well as to review the domestic and foreign research progress of Rehabilitation Outcome Measure in rehabilitation medicine field, and aim to provide some understanding and promote development of theoretical concepts and clinical implications of Rehabilitation Outcome Measure for domestic rehabilitation and health medicine specialists.

Objective To resolve the problem of this field including differences between ancient and modern concept,fuzzy meaning,synonyms,polysemy,then can use the knowledge in ancient book better and provide terminology support for development of stroke rehabilitation.Methods Explore on the method of constructing ancient and modern terminology database of stroke rehabilitation based on ontology,through collecting concepts,terminologys,strings in domin of stroke rehabilitation,defining the core concepts and analyzing the relationshop between concepts,then using software of ontology to construct the terminology database of stroke rehabilitation.Results Through collecting concepts,terminologys,strings in domin of stroke rehabilitation,we try to constructe a small ancient and modern terminology database of stroke rehabilitation with the technology of ontology,then query and graphical display this database.Conclusion Ontology is an effective way to construct field knowledge and communicate the ancient and modern concept of rehabilitation of stroke.