BACKGROUNDThe aim of this study was to evaluate the efficacy of ezetimibe combined with atorvastatin in treatment of carotid artery plaque in patients with type 2 diabetes mellitus complicated with coronary heart disease (CHD).METHODSA total of 100 patients with carotid atherosclerosis (CAS) confirmed by ultrasound and diagnosed with type 2 diabetes mellitus and CHD were randomly assigned to atorvastatin group (atorvastatin 20 mg/day) or combined treatment group (ezetimibe 10 mg/day and atorvastatin 20 mg/day). All those patients were followed for 12 months. Serum lipid, ALT, AST, and CK were measured before and after treatment. Ultrasonography was used to evaluate the stability of carotid artery plaques.RESULTSAfter 12 months of treatment, the level of TC, TG, LDL-C, hs-CRP, FPG and HbA1c decreased in both groups compared with before treatment. TC, TG, LDL-C and hs-CRP in the combined treatment group were much lower than that in the atorvastatin group (P<0.05). The IMT and plaque area in the two groups were lower than that before the treatment (P<0.05). IMT and plaques area in the combined treatment group is much lower than that in the atorvastatin group after treatment. There was no significant difference in two groups on the level of ALT, AST, CK compared with baseline after treatment.CONCLUSIONSThe effect of combined use of atorvastatin and ezetimibe was better than atorvastatin alone, which can effectively reduce the blood lipid levels in diabetic patients with CHD and improve plaque stability. Both treatment regimens were safe and well tolerated.

Type 2 diabetes mellitus (T2DM) patients treated with metformin are predisposed to develop contrast-induced nephropathy (CIN) after received emergency contrast-enhanced computed tomography (CT) examination. We evaluated the protective effects of alprostadil on CIN in T2DM patients treated with metformin after contrast media (CM) administration.

目的:探讨养血止痒合剂对尿毒症患者瘙痒的临床疗效;方法:选取尿毒症维持性血透皮肤瘙痒31例患者作为研究对象,采用常规治疗+养血止痒合剂药浴治疗;结果:治愈13例,显效4例,有效11例,无效3例,治疗有效率为90.32%;症状评分明显低于治疗前;结论:养血止痒合剂药浴治疗尿毒症患者瘙痒,效果显著,值得临床推广应用.

《素问·汤液醪醴论》中"帝曰:其有不从毫毛而生,五脏阳以竭也,津液充廓,其魄独居,孤精于内,气耗于外,形不可与衣相保,此四极急而动中,是气拒于内,而形施于外,治之奈何?岐伯曰:平治于权衡,去菀陈,微动四极,温衣,缪刺其处,以复其形,开鬼门,洁净府,精以时服,五阳已布,疏涤五脏,故精自生,形自盛,骨肉相保,巨气乃平."后世医家将其解读为排毒三大手段.尿毒症患者,肾气衰微,膀胱气化无权,水液糟粕无以排出,蓄积体内,致阴阳失衡,外邪集聚.现代医学认为调节电解质和水液平衡的器官有呼吸道(肺)、肾、消化道(肠)、皮肤.尿毒症患者肾脏损坏严重,其洁净府功能残留少许,不能满足人体的需要,消化道代偿性增加毒素和水液的排泄,此即去菀陈;尿毒症患者皮肤干燥,加之钙磷皮肤沉积,多数患者无汗或者极少出汗,其开鬼门的功能亦有所下降.我们采用外治法治疗尿毒症,取得了不错的治疗效果,具体报告见下文.

<正>自1954年美国Murray首次进行肾移植手术获得成功以来,临床肾移植已走过了半世纪的历程[1]。随着传统生物医学模式向生物一心理一社会医学模式转化,围绕移植所产生的社会心理问题、行为与生活方式对健康状况的影响日益受到国内外学者的关注。对疾病的预后及临床疗效的评价从过去单纯用生存率、复发率等生物学指标逐渐转向对患者生理、心理、社会功能等诸方面综合评估[2]。本着"全心全意为广大肾友服务"的宗旨我们于2004年在我院成立了"肾友俱乐部",目的是为肾友提供一个交流的平台,加强医护与肾友之间的互相交流、相互沟通,为肾友们更好的生活,工作以及融入社会,尽量帮助有生活困难的移植家庭,从而推动肾移植手术的发展。现介绍我科以肾友俱乐部为依托的回访系统。

Objective To study the effect of Danshen and Huangqi recipe on chronic rejection in renal transplanted rat.Methods To establish the model with WISTER and SD rat.Experimental rats were divided into 3 groups.IL-2,IL-4 and IFN-γ were assessed at 4,8,12,16 week after transplanta-tion.Results Serum interleukin 2,interleukin 4 and interferon gamma gradually increased with the time prolonged.And it decreased in 16 weeks.It was significantly decreased after the application of Salvia Astragalus mixture.Conclusion Salvia Astragalus mixture can effectively reduce serum interleukin 2,interleukin 4 and interferon gamma concen-tration in the rat who had renal transplated.

目的 总结不同治疗方法对CKD-5D 期脑出血患者的预后的影响.方法 通过回顾青岛中西医结合医院2005-2012 年收治的21 例次CKD-5D 期合并脑出血患者的治疗,总结间断肾脏替代治疗(间断血液透析和间断血液滤过)与每日血液透析治疗CKD-5D 期合并脑出血的临床效果.结果 每日血液透析组患者的总体好转率、死亡率好于间断肾脏替代.结论 每日血液透析是治疗CKD-5D 期合并脑出血的较理想的方法.