Представить обзор профессиональной, научной и педагогической деятельности известного российского ученого в области уголовного процесса и криминалистики Виктора Николаевича Григорьева. Профессор В.Н. Григорьев является выдающимся ученым и педагогом, вносящим существенный вклад в развитие доктрин уголовного процесса и криминалистики и играющим важную роль в подготовке как юридических, так и научно-педагогических и научных кадров. В.Н. Григорьев написал и опубликовал значительное количество научных, учебных и учебно-методических работ, а под его чутким руководством разрабатываются новые научные направления, функционирует научная школа. В данной статье анализируются выдающиеся научные и педагогические достижения профессора В.Н. Григорьева, показывается их значение для дальнейшего развития уголовно-правовых наук, воспроизводства юридических кадров наивысшей квалификации

At present, selective amygdalohippocampectomy (SAH) has become popular in the treatment of drug-resistant mesial temporal lobe epilepsy (TLE). However, there is still an ongoing discussion about the advantages and disadvantages of this approach. The study included a consecutive series of 43 adult patients with drug-resistant TLE, involving 24 women and 19 men (1.8/1). Surgeries were performed at the Burdenko Neurosurgery Center from 2016 to 2019. To perform subtemporal SAH through the burr hole with the diameter of 14 mm, we used two types of approaches: preauricular, 25 cases, and supra-auricular, 18 cases. The follow-up ranged from 36 to 78 months (median 59 months). One patient died 16 months after surgery (accident). By the third year after surgery, Engel I outcome was achieved in 80.9

IV (XXVII) Национальный конгресс эндокринологов с международным участием «ИННОВАЦИОННЫЕ ТЕХНОЛОГИИ В ЭНДОКРИНОЛОГИИ» 22-25 сентября 2021 года НАРУШЕНИЯ ПСИХИЧЕСКОЙ ДЕЯТЕЛЬНОСТИ В КЛИНИЧЕСКОЙ КАРТИНЕ КРАНИОФАРИНГИОМ У ВЗРОСЛЫХ 1,2 Сиднева Ю .Г ., 1 Астафьева Л .

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

The vegetative state and mutism are long-term states of unconsciousness. Nowadays, brain responses to naturalistic stimuli are studied to investigate the cognitive functions preservation. Wavelet-analysis is a method used to assess the brain’s bioelectrical activity. Thereby, nine patients were investigated. Four of them were in a vegetative state (three patients were later noted consciousness recovery) and five patients were in mutism (four patients had consciousness recovery). The control group consisted of ten healthy subjects. Biopotentials’ recording was performed using thirty-two electrodes located in the system of 10–20%. Six music-passages were used as stimuli. One fragment was repeated eleven times (each fragment duration was four seconds). Wavelet-synchrony was calculated over all electrode pairs. In healthy subjects, the maximum values of wavelet-synchrony in resting-state and when listening to stimuli were detected in the fronto-central-parietal areas. Important feature was the presence of inter-hemispheric and diagonal connections. Also it was revealed for patients in a reversible vegetative state. Resting-state values of wavelet-synchrony in patients in a vegetative state were less the norm, and those in patients in mutism were higher the norm. The patients in a chronic vegetative state have an increase in wavelet-synchrony values relative to the resting-state with a tight localization. In the same time local amplification of wavelet-synchrony was noted in a patient in a chronic mutism. In conclusion, the identified features in the naturalistic stimuli perception can be used as prediction of a possible consciousness recovery in patients in a vegetative state and mutism. The study was supported RFFI 18-013-00967a.

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

tomorrow suicide rates – and decrease them. Introduction: Neuropsychological rehabilitation is needed in case of disorders of higher mental functions (HMF) due to various brain diseases of traumatic, hypoxic, vascular, inflammatory, atrophic or neoplastic genesis. is of the and duration of a coma and post-comatose unconscious state in the acute phase of brain A coma up to seven days’ results in moderate disability so-called complete whereas a longer coma increases the risk of severe disability. Even a one-to-two-day post-comatose unconscious state triples (17 to 56%) the risk of low-reversible cognitive disorders in the late period after TBI. Only 7% of patients having a post-comatose unconscious state for more than one month end up with moderate to mild cognitive disorders.

Supratentorial hematoma is the most common mass lesion found in traumatic brain injury (TBI) and is associated with high mortality and disability rates.The annual incidence of the aforementioned is 20 cases per 100,000 populations.

The purpose of this study is to estimate the therapeutic potential of transcranial magnetic stimulation (TMS) in patients after traumatic brain injury (TBI) with impaired consciousness and motor activity. Observation groups: (1)19 patients after TBI at the age of 16–50 with a prolonged (from 60 to 360 days) unconscious state in which the rhythmic TMS was performed; (2) Control group: 6 healthy men aged 22–28. Changes of neurological status, indicators of the memory and attention, and N100, N200 and P300 components of auditory ERP hour before and hour after stimulation, the dynamics of diagnostic TMS and bimodal (somatosensory and short latency auditory) EP's were estimated. Therapeutic rTMS of the sagittal premotor cortex areas in both groups concurred with improvement of any attention and normalization of amplitude and latency of all ERP components, especially for P300. rTMS of the frontal lobes facilitated positive clinical dynamics, while rTMS of the parietal lobes did not prove any clear positive effects. The obtained data proposes the availability of using rTMS for therapeutic purposes in patients with PUS. The most promising targets for stimulation at the moment seems to be the frontal and sagittal premotor areas of the brain. Further research is required to clarify the areas and parameters of stimulation. Supported by: RFFI N 16-29-08304.

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Recovery of both mental and motor functions is one of the key problems of neurorehabilitation of patients with traumatic brain injury (TBI), accompanied by posttraumatic unconsciousness state (PUS). The purpose of pilot study is to clarify the diagnostic and therapeutic potential of TMS in patients after TBI with impaired motor activity and consciousness. Observation groups: (1) 15 patients after TBI at the age of 17–56, in which the diagnostic TMS (cortical motor areas (M1) bilaterally, CVII bilaterally, registration of MEPs from musculus abductor pollicis brevis) was performed; (2) 9 patients after TBI at the age of 16–44 with a prolonged (from 60 to 220 days) unconscious state in which the rhythmic TMS was performed; (3) Control group: 5 healthy men aged 22–28. Diagnostic TMS evaluated cortical, radicular latency and amplitude of MEPs,time of central motor conduction. In the second and third groups changes of neurological status, indicators of the memory and attention, and N100, N200 and P300 components of auditory ERP hour before and hour after stimulation were estimated. Diagnostic TMS in patients with positive or ambiguous clinical dynamics showed initial difference of conductivity of tracts in comparison with normal data by 20–30% or 30–40%, respectively, with progressive improvement as motor and cognitive functions recovered. In patients with negative clinical dynamics TMS values had significantly larger deviation of cortical latency and amplitudes of MEPs (over 45%), and also the time of central motor conduction. Statistical analysis of acquired data revealed the greatest prognostic significance for determining the level of the amplitudes of MEPs with undeniable importance for the indicators of cortical latency and the time of central motor conduction. Therapeutic TMS of the sagittal premotor cortex areas in groups 2 and 3 concurred with improvement of any attention and normalization of amplitude and latency of all ERP components, as well as indicators of their spatial synchronism, especially for P300. The obtained data clarifies diagnostic parameters of TMS and proposes the availability of using rTMS for therapeutic purposes in patients with PUS. RFFI N16-29-08304.