目的 观察麝香保心丸辅助治疗慢性心力衰竭(CHF)的效果.方法 2014年1月至2016年5月该院收治的CHF患者82例,随机分为观察组与对照组各41例.对照组采用CHF常规治疗,观察组在对照组基础上联合麝香保心丸治疗.比较两组治疗前后内皮功能、炎症因子水平、心功能参数及临床疗效.结果 观察组总有效率(92.7％)高于对照组(85.4％),但差异无统计学意义(P>0.05);治疗后观察组一氧化氮水平及左心室射血分数、6分钟步行试验值高于对照组,内皮素-1、可溶性细胞黏附因子-1、IL-6水平及左心室舒张末期内径、脑钠肽水平低于对照组,差异有统计学意义(P<0.05).结论 麝香保心丸辅助治疗慢性心力衰竭效果满意,能有效改善患者血管内皮功能和抑制炎症反应,从而改善心功能.
目的 探讨维持性血液透析(MHD)患者肾性贫血纠正情况及其影响因素.方法 收集2017年9月至2019年9月行MHD治疗患者188例.根据血红蛋白水平分为A、B、C、D四组,比较各组间基线水平及CRP、TSAT、SF、preALB、ALB、iPTH、Ca2+、P3-、TG、TC等实验室指标的差异,分析影响肾性贫血达标的影响因素.结果 preALB、ALB、TSAT水平,A组>B组>C组>D组逐渐降低,四组比较差异有统计学意义(P<0.05).iPTH、P3-、CRP水平,A组0.05).结论 MHD患者肾性贫血治疗达标率较低,透前CRP、TSAT、preALB、ALB、iPTH、P3-是MHD患者贫血不达标的影响因素.
Objective To explore the influencing factors of quality of life and negative emotions in maintenance hemodialysis(MHD)patients. Methods 188 cases of maintenance hemodialysis in Zhejiang medical &health group Hangzhou Hospital and Haining People's Hospital from September 2017 to September 2018 were selected. Self-rating Depression Scale(SDS)and Self-rating Anxiety Scale(SAS)were used to assess patients' emotional status,Meanwhile,CRP,Hb,SF,Alb and dialysis adequacy(KT/V)indicators which reflecting the quality of life of hemodialysis patients were evaluated,and the influence factors of quality of life on negative emotions of maintenance dialysis patients were analyzed. Results Among 188 MHD patients,the incidence of depression(SDS≥50)was 38.8%,and anxiety(SAS≥50)was 37.8%. The SDS and SAS scores of MHD patients with age>60 years,dialysis age>1year or diabetes mellitus were significantly higher than those of MHD patients with age ≤60 years,dialysis age ≤1 year or without diabetes mellitus,statistical difference was statistically significant(P<0.05);Hb,SF and Alb were negatively correlated with SDS and SAS(r was -0.38,-0.31,-0.26,P<0.05);and S-CRP was positively correlated with SDS and SAS(r=0.28,P<0.05). Conclusion The incidence of negative emotions is higher in MHD patients,and the quality of life affects the negative emotions of MHD patients.
