Insomnia, a prevalent neurological disease, is characterized by neurotransmitter disorder, inflammation and oxidative stress. Current treatments are often limited in efficacy due to their single-target regulatory mechanisms. YiNianJin (YNJ) is a classical formula that employs multiple therapeutic effects in treating insomnia. However, conventional oral delivery of YNJ formula is challenged by notable limitations, including Hg2+ accumulation released from cinnabar, limited bioavailability of active constituents, that resulted in both of the toxicity issue and limited therapeutic efficacy. To address these multiple obstacles, we developed a peptide self-assembled penetrating nanovesicles integrated within a controlled releasing matrix, forming into YNJ patch (YNJP). Cinnabar is encapsulated within nanovesicles functionalized with cell-penetrating (YGRKKRRQRRR, TAT) and intestinal wall-penetrating (CSKSSDYQC, CSK) peptides, forming TAT/CSK-cinnabar vesicles (TCCV), and integrated into a controlled-release polymeric matrix, loaded with other herbal components, forming into a hybrid patch. YNJP is shown to significantly enhance the sequential penetration of cinnabar across the stratum corneum (SC), abdominal fat, and small intestinal wall, along with the obvious efficacy in the transdermal delivery of other herbal components. Compared with the conventional oral delivery of YNJ, YNJP significantly reduced the Hg2+ accumulation in major organs by 58.3%–85.8%. In addition to inhibit the inflammation and oxidative stress to relieve insomnia, YNJP can also restore the brain-gut axis mediated serotonin (5-HT) release and 5-HT1A receptors (5-HT1AR) activation, representing a safe and innovative transdermal delivery platform for Chinese formulae containing both multiple homogenous components and toxic compound, as well as offering a new Chinese medicine scheme for the treatment of complex disorders such as insomnia with high efficiency and biosafety.

BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive, age-related lung disease with few modifiable risk factors. While healthy dietary patterns have been associated with reduced risk of chronic diseases, their impact on IPF remains unclear. This study investigated the relationship between adherence to healthy dietary patterns and incident IPF and explored whether phenotypic age acceleration mediates this association. METHODS:We analyzed 196,473 participants from the UK Biobank. Dietary intake was assessed via repeated 24 -h recall questionnaires, and adherence scores were calculated for the DASH, MEDAS, and MIND dietary patterns. Cox proportional hazards models were used to estimate the association between dietary scores and incident IPF. Mediation analysis was conducted to examine the role of phenotypic age acceleration. RESULTS:During a median follow-up of 12.4 years, 516 IPF cases were identified. Higher adherence to all three dietary patterns was significantly associated with a reduced risk of IPF. In fully adjusted models, hazard ratios for the highest vs. lowest quartiles were 0.75 (95% CI: 0.59-0.95) for DASH, 0.53 (0.37-0.75) for MEDAS, and 0.66 (0.51-0.86) for MIND. Phenotypic age acceleration partially mediated these associations. CONCLUSIONS:Higher dietary scores were associated with a lower risk of incident IPF, partially mediated by reduced phenotypic age acceleration. These findings suggest that promoting healthy eating habits may contribute to reducing age-related lung disease burden in older adults.

Background Respiratory health is closely related to immune system function, and diet can also influence immune homeostasis. Diet, an important part of a healthy lifestyle, is also linked to respiratory health. We aimed to explore the relationship between different dietary patterns and the risk of chronic respiratory diseases (CRDs), including chronic bronchitis (CB), emphysema, and asthma.Method A total of 23,042 adults from the United States were selected from the National Health and Nutrition Examination Survey (NHANES) dataset between 2007 and 2018. Diet quality was assessed using 2-day, 24-hour dietary recall data and quantified as the Healthy Eating Index-2020 (HEI-2020), the Dietary Inflammation Index (DII), the Mediterranean Dietary Index (MEDI), and the Dietary Approaches to Stop Hypertension Index (DASHI). Binary logistic regression models, restricted cubic splines (RCS), and the weighted quartile sum (WQS) models were used to assess the relationship between diet quality and the risk of CB, emphysema, and asthma.Results In logistic regression analyses of the four dietary indices with the three chronic respiratory diseases, it was consistently observed that higher dietary quality scores were linked to a reduced risk of respiratory disease. These consistent trends were also evident in the assessments of the dose-response relationship between dietary quality score and the risk of respiratory disease. Furthermore, evaluations of the combined effects of dietary components across different dietary indices in the risk of chronic respiratory disease yielded results consistent with the logistic regression models. Notably, high-quality protein, minerals, and fiber-rich fruits and vegetables emerged as the food groups making the most significant contributions to health across different dietary indices.Conclusion Low-quality diets, lacking in high-quality protein, minerals, and fruits and vegetables rich in dietary fiber, are associated with a higher risk of chronic respiratory disease, regardless of the dietary index used to measure diet quality.

Benign prostatic hyperplasia(BPH) is a common disease in middle-aged and elderly men, with lower urinary tract symptoms as the main manifestation, severely affecting the quality of life of patients. The pathogenesis of BPH is not yet fully understood, and there are still some challenges and limitations in western medicine treatment for BPH. Therefore, finding new and more effective treatment strategies is urgent. In recent years, many basic and clinical studies have confirmed the important role of traditional Chinese medicine in the treatment of BPH. This article reviews the progress of basic and clinical research in the treatment of BPH with traditional Chinese medicine, and believes that basic research mainly focuses on the active ingredients of Chinese medicine [regulating pathways such as NF-E2-related factor 2(Nrf2)/antioxidant response element(ARE), nuclear factor κB(NF-κB), epidermal growth factor receptor(EGFR)/signal transducer and activator of transcription 3(STAT3), phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR), p38 mitogen-activated protein kinase(p38 MAPK)/forkhead box O subtype(FOXO3a), etc.], single Chinese herbs(regulating inflammatory factors, oxidative stress-related proteins, cell cycle-related proteins, and apoptotic factors, etc.), and Chinese herbal compounds and patent medicines [regulating extracellular signal-regulated kinase(ERK1/2), transforming growth factor-β(TGF-β)/Smad, mitogen-activated protein kinase(MAPK), PI3K/Akt, Nrf2, trefoil factor 2(TFF2)/Wnt, interleukin-6(IL-6)/Janus kinase 2(JAK2)/STAT3, hypoxia-inducible factor 1α(HIF-1α)/vascular endothelial growth factor receptor(VEGFR), etc.], and then play a therapeutic role by inhibiting BPH cell proliferation, oxidative stress, inflammatory response, promoting apoptosis, and inhibiting epithelial-mesenchymal transition. Clinical studies mainly focus on internal treatment, external treatment, combined internal and external treatment, and integrated Chinese and western medicine treatment as the main methods, aiming to improve traditional Chinese medicine syndrome scores, prostate symptom scores, residual urine volume, effective bladder volume, sexual quality of life, increase average urine flow rate, maximum urine flow rate, and promote balance of sex hormone secretion. Through this research, it is hoped to provide some reference ideas for clinical research and drug development for BPH.

支气管哮喘慢性持续期的临床分型尚无统一标准,课题组前期对其中医临床表型进行了初步探索,发现虚寒证与虚热证之间在单核苷酸多态性(SNP)与甲基化基因表达与分布上有显著差异,现对慢性持续期虚寒证的理论基础和发病机制进行探讨.

Objective:To summarize the use of Chinese Herbal Medicines (CHMs) for Idiopathic Pulmonary Fibrosis (IPF) and provide high-level evidence for clinical decisions.Methods:We analyzed systematic reviews (SRs). Two English-language and three Chinese-language electronic databases were searched from inception to July 1, 2019. Published SRs and meta-analyses evaluating CHM use in IPF and reporting clinically-relevant outcomes such as lung function, PO2, and quality of life were eligible for inclusion in this overview. The methodological qualities of the included SRs were assessed by AMSTAR and ROBIS tools.Results:All reviews were published from 2008 to 2019. 15SRs were published in Chinese-language while 2 were in English. A total of 15550 participants were included. All intervention arms received CHM with or without conventional treatment and were compared with control arms with conventional treatment alone, or hormone therapy. Twelve SRs were assessed with low risk of bias while five were assessed high risk by ROBIS. The quality of evidence was assessed to be "moderate" or "low" or "very low" using GRADE.Conclusions:CHM has potential benefits for patients with IPF especially in improving lung function (forced vital capacity (FVC), total lung capacity (TLC), and diffusing capacity of the lungs for carbon monoxide (DLCO)), PO2 level, and the quality of life of patients. Due to the low methodological quality of reviews, our findings should be interpreted with caution.

Tanhuo formula (THF), a traditional Chinese medicinal formula, has been demonstrated to be effective in the clinical treatment of acute ischemic stroke (AIS). However, its active ingredients, potential targets, and molecular mechanisms remain unknown. Based on the validation of active ingredient concentrations, our study attempted to elucidate the possible mechanisms of THF based on network pharmacological analysis and experimental validation. Components of THF were screened using network pharmacological analysis, and a compound–target network and protein–protein interaction (PPI) network were constructed. In total, 42 bioactive compounds and 159 THF targets related to AIS were identified. The PPI network identified AKT1, TNF, IL6, IL1B, and CASP3 as key targets. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis demonstrated that the inflammation and apoptotic pathways were enriched by multiple targets. The main components of THF were identified via high-performance liquid chromatography. Subsequently, a validation experiment was conducted, and the expressions of GFAP, C3, TNF-α, and IL-6 were detected via immunofluorescence staining, confirming the inflammatory response at 30 min and 3 days post injury. Immunohistochemical staining for caspase-3 and TUNEL was also performed to assess apoptosis at the same time points. These results indicate that THF can effectively decrease neural cell apoptosis through the caspase-3 pathway and restrain excessive abnormal activation of astrocytes and the release of TNF-α and IL-6, which might be accompanied by the recovery of motor function. Thus, THF may serve as a promising therapeutic strategy for AIS through multiple targets, components, and pathways.

Background: We tried to investigate the effect of PM2.5 on daily counts of outpatient visits in the Guang’anmen Hospital to determine if short-term PM2.5 exposure with extremely high concentration affects cardiopulmonary function of Beijing residents. Methods: Outpatient visits and PM2.5 data from 01/11/2011 to 03/31/2013 were extracted from the Guang’anmen Hospital and the American Embassy in Beijing, respectively. Followed by using a semi-parametric generalized additive model (GAM) with time dependent covariates, we analyzed the association between PM2.5 concentrations and daily count of outpatient visits on Day 0, 1, 2, 3, 4 and 5 of PM2.5 exposure. Results: Overall, 284354 subjects were collected. There were significant associations of short-term PM2.5 exposures with outpatient visits for cardiopulmonary diseases (P<0.05). Specifically, a 10 μg/m3 increase in PM2.5 was positively associated with a 0.74% of increase in angina visit on the first day and 0.50% increased visit on the second day (P<0.05). With an increase in PM2.5, the cough and respiratory visits significantly decreased by 0.17% and 0.30% on the first day, respectively (P<0.05). However, there were significant positive associations of PM2.5 with increased cough and respiratory visits (increased by 0.17% and 0.10%, respectively) on the fifth day (P<0.05). Conclusion: Our association studies showed an instant effect of PM2.5 level on cardiovascular outpatient visit in the Guang’anmen Hospital in Beijing while a lag effect on respiratory outpatient visits.

我国是一个机械大国,近年来,我国的机械行业在发展的过程中也取得了令人瞩目的成绩,但我们国家并不是一个机械强国。世界范围内的机械行业的高精尖的技术都在发达国家。因此,我们要加快我国机械设计自动化的发展步伐,力争在有限的时间内赶超先进的国家。文中从机械自动化系统的特点和发展趋势谈起,重点介绍了机械自动化在提高企业的生产率,增加企业利润方面所起的不可替代的作用,并指明了机械自动化的发展要从智能化、绿色化、模块化和微型化方面进行,使机械自动化更能为社会服务,为人们带来更大的便利。

随着互联网经济的迅速进步,电子商务的优势变得越来越突出.基于这种形式的网络营销非常快捷,便利,互动性也比较强,它渐渐变成了新世纪最重要的经济发展观点.本文根据现在信息时代的进步情况对网络营销对国贸未来发展的影响进行分析,并通过其发展过程中存在的问题有针对性的制订了一定的解决措施.

OBJECTIVE:To explore the effect of Peitu Shengjin Recipe (PSR) on nutritional states and immune functions of stable phase chronic obstructive pulmonary disease (COPD) patients. METHODS:Totally 62 stable phase COPD patients were randomly assigned to the treatment group (30 cases) and the control group (32 cases). All patients inhaled Seretide (50/500 µg), twice per day. Besides, patients in the treatment group additionally received PSR, one dose per day. After three months of treatment, the COPD assessment test (CAT) score, the index of nutritional states [including body mass index (BMI) , thickness of skin fold (TSF), mid-arm muscle circumference (MAMC), serum albumin, serum prealbumin], and immune functions (including IgA, IgM, and IgG) were compared between the two groups. RESULTS:By the end of the treatment, the CAT score decreased more obviously in the treatment group than in the control group (P < 0.05). The improvement of BMI, TSF, MAMC, serum albumin, and serum prealbumin was better in the treatment group than in the control group (P < 0.05). IgM and IgG also increased more in the treatment group (P < 0.05). There was no statistical difference in IgA between the two groups (P > 0.05). CONCLUSIONS:Additionally use of PSR could improve nutritional states and immune functions of stable phase COPD patients to some extent. Meanwhile, it also could improve their health related quality of life.

近年来,人们的生活随着信息网络化而发生改变,优质的广播电视传输为其带来了视觉上的享受和精神上的满足.然而,广播电视传输系统的维护工作却极不易做.本文简要阐述了广播电视传输的日常维护特征,并从严格控制温度和湿度、科学设置传输设备、做好防尘防鼠工作等四个方面对广播电视传输系统的日常维护路径做了具体分析,以期为广播电视传输系统维护工作提供参考意见,使传输服务更加优质、高效.

It is well documented that the psychiatric disorders are common in Asthma patients in China while the studies on the relationship between asthma control and psychological disorder are comparatively rare. We therefore performed a cross-sectional study on asthmatic outpatients in one Chinese tertiary center to investigate the correlation among asthma, anxiety and depression. Demographic data, anxiety and depression scores, the level of asthma control were collected in 261 patients. All patients were evaluated with Asthma Control Test (ACT), Self-Rating Anxiety Scale (SAS) and Self-rating depression scale (SDS) questionnaires. A multivariate analysis was performed to investigate the relationship between asthma control and psychological disorder. The result showed that 31 asthma patients had anxiety symptom while thirty-five asthma patients had depression. One hundred and ninety-two asthma patients were well controlled and 69 patients were not. The study found a negative correlation between ACT and SAS(r = -0.231, p<0.001) as well as ACT and SDS(r = -0.23, p<0.001) and depression (OR: 12.295, 95% CI: [5.374-28.128], p<0.001) were both independently associated with poor asthma control. We concluded that Asthma control is greatly affected by psychological disorder in Chinese patients.

SESSION TYPE: Respiratory Infections Posters II

投标是一门技术，更是一门学问。投标文件代表着企业的形象，在如何组织编制好投标文件，争取在众多投标单位中脱颖而出，获取中标资格中起着举足轻重的作用。结合近几年来的投标工作经验，对投标文件商务资料编制的要点及容易出现的问题，进行以下分析，提出相应的技术措施及注意事项，从而提高投标过程中商务部门的工作效率及标书的编制水平，为顺利中标迈出坚实的第一步。