The paper analyses genetic polymorphism of thrombophilia in 68 patients with thromboembolia of the pulmonary artery (PATE) in Pimorsky Krai. The polymorphisms in genes associated with the risk factors for thrombophilia and venous thromboembolic complications was somewhat distinctive in comparison with that of the European population, and, foremost, it was represented by mutations in genes of folate cycle (97.1 % of cases) and disorders related to plasminogen activator inhibitor type 1 gene (88.2 % of cases). The genetic predisposition to hyperaggregation of platelets was recorded in more than half of the patients (55.9 %). The synergism of thrombosis risk factors was observed in all PATE cases. These changes shall be allowed for when developing programs for secondary prevention of venous thromboembolic complications. The therapy shall be continuous and likely to last throughout the life, and include drugs known to have effect on different coagulation system components, based upon both laboratory findings that are indicative of haemostatic disorders, and foremost, molecular genetic testing results.
In the article the case of diffuse lymphangioleiomyomatosis of the lung at 21 year-old women is described The disease has manifested on the 38th week of the pregnancy. Leiomyomas of others localizations were absent. The clinical course was malignant: in 22 days after disease's manifestation women had died. The possible mechanisms of uncontrolled proliferation of nonstriated muscle's elements and features of lymphangioleiomyoma's morphological diagnostics are discussed.
It was analyzed for pneumonia in 24 patients in the epidemic season of influenza A/H1N1 in October 2009 April 2010 in Primorsky Krai. They required urgent hospitalization in the intensive care unit and required in massive antiviral, wide spectrum antibacterial combined therapy, interferons, immunoglobulins, anticoagulants management. Women have been involved mostly. The pregnant women had the most severe pneumonia. The experience of treatment such pneumonia has been demonstrated.