Ulcerative colitis is recurrent inflammatory disorder of the large intestine characterized by continuous expansion of bowel involvement, from the rectum to the proximal parts. Despite certain similar sign with adults, ulcerative colitis in children has a number of special features and distinctions to disease course and therapy response, therefore such peculiarities should be considered while choosing the management strategy. In 2012 European Crohn’s and Colitis Organisation and European Society for Pediatric Gastroenterology, Hepatology and Nutrition developed collaborated recommendations on diagnostics and treatment of ulcerative colitis in children based on the evidence-based medicine. On the base of European recommendations and with regard to Russian peculiarities and experience of management of children with ulcerative colitis the Russian Consensus on Ulcerative Colitis in children was developed by the group of the chief pediatric gastroenterologists specializing in inflammatory bowel diseases in children. This Consensus was approved on the 15th of February 2013 at the Expert Counsel on Development of the Russian Consensus, which took place during the XVII Summit of Pediatricians of Russia. These recommendations contain standardized protocols, which allow to provide timely and efficient diagnostics, treatment and follow-up of children with ulcerative colitis. It is necessary to mention, that this Consensus is not a doctrine and individual features of each patient and modern scientifically based data must be taken into account.

Periodic fever — is a hereditary autosomal — recessive disease that is characterized by recurrent serositis and frequent amyloidosis development. One of the most common symptoms of this disease is abdominal pain. This article contains modern approach to pathogenesis, diagnostics and treatment of periodic fever. There is also a correlation analysis of dependence of periodic fever clinical course from gene MEFV mutation, as well as practice of selective M-cholinergic antagonist gioscine buthilbromide for abdominal pain relief in children and adolescents. Key words: periodic fever, abdominal pain, gioscine buthilbromide. (Voprosy sovremennoi pediatrii — Current Pediatrics. — 2011; 10 (5): 138–142.)

Periodic fever is a hereditary autosomal recessive disease that is characterized by recurrent serositis and frequent amyloidosis development. One of the most common symptoms of this disease is abdominal pain. This article contains modern approach to pathogenesis, diagnostics and treatment of periodic fever. There is also a correlation analysis of dependence of periodic fever clinical course from gene MEFV mutation, as well as practice of selective M-cholinergic antagonist gioscine buthilbromide for abdominal pain relief in children and adolescents

Периодическая болезнь (ПБ) — наследственное аутосомно-рецессивное заболевание, проявляющееся рецидиви-рующим серозитом и частым развитием амилоидоза. Одним из наиболее распространенных симптомов при дан-ной патологии является абдоминальная боль. В статье представлены современные взгляды на патогенез, подходы к диагностике и лечению периодической болезни. Приводится корреляционный анализ зависимости течения ПБ от варианта мутации в гене MEFV, а также опыт применения селективного блокатора М-холинорецепторов гиосцина бутилбромида для купирования болевого абдоминального синдрома у детей и подростков.Ключевые слова: периодическая болезнь, болевой абдоминальный синдром, гиосцина бутилбромид.

Authors discuss the problem of constipation in children and modern approach to treatment and prophylaxis of this disorder in children of different age group. Stimulating effectiveness of laxative agents and spasmolytics are analyzed. Effectiveness of sodium picosulfate (Guttalax) in monotherapy was compared with combined treatment with sodium picosulfate and spasmolytic (Buscopan) in children with chronic constipation. Key words: children, chronic constipation, sodium picosulfate, hyoscine butylbromide. ( Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(1): 85-89 )

Authors discuss the problem of constipation in children and modern approach to treatment and prophylaxis of this disorder in children of different age group. Stimulating effectiveness of laxative agents and spasmolytics are analyzed. Effectiveness of sodium picosulfate (Guttalax) in monotherapy was compared with combined treatment with sodium picosulfate and spasmolytic (Buscopan) in children with chronic constipation.Key words: children, chronic constipation, sodium picosulfate, hyoscine butylbromide.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(1):85-89)

AN OPEN COMPARATIVE RANDOMIZED STUDY EVALUATES THE PROBIOTIC THERAPY EFFICACY IN 59 CHILDREN AGED 6-17 WITH A MEDICATION CONTAINING FREEZE-DRIED STRAINS OF BIFIDOBACTERIUM INFANTIS V. LIBERORUM, LACTOBACILLUS ACIDOPHILUS AND STREPTOCOCCUS FAECIUM (LINEX, LEK, SLOVENIA). THE TREATED DISEASE WAS ANTIBIOTIC-ASSOCIATED INTESTINAL DYSBACTERIOSIS DEVELOPED ON THE BACKGROUND OF ANTICHELICOBACTERIAL THERAPY. THE MAJOR GROUP COMPRISED 38 PATIENTS, AND THE COMPARISON GROUP COMPRISED 21 CHILDREN. PATIENTS FROM BOTH GROUPS WERE COMPARABLE IN TERMS OF DEMOGRAPHIC AND CLINICAL CHARACTERISTICS. THE STUDY FOCUSED ON THE CLINICAL DATA AND THE RESULTS OF THE INTESTINAL FLORA AND VOLATILE FATTY ACID SURVEY. THE STUDY SHOWED THAT IN THE MAJORITY OF PATIENTS ANTICHELICOBACTERIAL THERAPY CONCURS WITH ANTIBIOTIC-ASSOCIATED INTESTINAL DYSBACTERIOSIS. YET, THE MEDICATION CONTAINING FREEZE-DRIED STRAINS OF BIFIDOBACTERIUM INFANTIS V. LIBERORUM, LACTOBACILLUS ACIDOPHILUS AND STREPTOCOCCUS FAECIUM REDUCES THE ANTIBIOTIC-ASSOCIATED INTESTINAL DYSBACTERIOSIS DEVELOPMENT RISK, AND ITS EFFECT MANIFESTS ITSELF THROUGH CLINICAL IMPROVEMENT, NORMALIZED INTESTINAL MICRO FLORA AND RESTORED METABOLISM.

The growth rate of inflammatory bowel diseases among children actualizes early detection of this pathology form and its aftera effects, including secondary osteoporosis. The research purpose is to study the characteristics of osseous tissue mineralization, disorder of physical growth and sexual maturity of children, suffering from inflammatory bowel diseases. The researchers have examined 116 children, including 33 children, suffering from inflammatory bowel diseases; 26 children, suffering from persistent colitis; 29 children, suffering from gasatroduodenitis; and 28 children with no GI tract pathologies. The study deals with estimate of level of mineral osseous tissue density, biochemical rates of osseous metabolism, as well as physical growth and sexual maturity. reduction of mineral osseous tissue density was found among 48,5% of children, suffering from inflammatory bowel diseases, 23% of children, suffering from persistent colitis, 31% of children, suffering from chronic gastritis and 18% of almost healthy children, at the same time, it was more apparent among children, suffering from inflammatory bowel diseases. The lowest rates of mineral osseous tissue density were among girls. Calcium phosphoric metabolism did not change apart from calcium creatinine coefficient, if osteopenia was observed. Thus, reduction of mineral osseous tissue density is often observed among children, suffering from inflammatory bowel diseases, especially among adolescent girls. Therefore, it conditions the necessity to include densimetry into the conventional examination plan for children, suffering from inflammatory bowel diseases. Authors also find it advisable to monitor physical growth and sexual maturity of children.Key words: children, inflammatory bowel diseases, osteoporosis.

The growth rate of inflammatory bowel diseases among children actualizes early detection of this pathology form and its aftera effects, including secondary osteoporosis. The research purpose is to study the characteristics of osseous tissue mineralization, disorder of physical growth and sexual maturity of children, suffering from inflammatory bowel diseases. The researchers have examined 116 children, including 33 children, suffering from inflammatory bowel diseases; 26 children, suffering from persistent colitis; 29 children, suffering from gasatroduodenitis; and 28 children with no GI tract pathologies. The study deals with estimate of level of mineral osseous tissue density, biochemical rates of osseous metabolism, as well as physical growth and sexual maturity. reduction of mineral osseous tissue density was found among 48,5% of children, suffering from inflammatory bowel diseases, 23% of children, suffering from persistent colitis, 31% of children, suffering from chronic gastritis and 18% of almost healthy children, at the same time, it was more apparent among children, suffering from inflammatory bowel diseases. The lowest rates of mineral osseous tissue density were among girls. Calcium phosphoric metabolism did not change apart from calcium creatinine coefficient, if osteopenia was observed. Thus, reduction of mineral osseous tissue density is often observed among children, suffering from inflammatory bowel diseases, especially among adolescent girls. Therefore, it conditions the necessity to include densimetry into the conventional examination plan for children, suffering from inflammatory bowel diseases. Authors also find it advisable to monitor physical growth and sexual maturity of children. Key words: children, inflammatory bowel diseases, osteoporosis.

The article presents an evaluation of five regimens of three-component antihelicobacter therapy in 114 children aged from 5 to 15 years with gastritis associated with Helicobacter pylori infection (according to morphological investigation and the rapid ure ase test).